R
Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin
David H. Spencer,Bilal Al-Khalil,David A. Russler-Germain,Tamara Lamprecht,Nicole Havey,Robert S. Fulton,Michelle O'Laughlin,Catrina Fronick,Richard K. Wilson,Timothy J. Ley +9 more
TL;DR: The genome-wide consequences of the DNMT3A R882H mutation on DNA methylation and chromatin structure are explored and it is unclear if the methylation differences caused by this mutation result in RNA expression changes at specific targets across the genome, or whether they are associated with altered Chromatin structure.
Journal ArticleDOI
Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers.
Zachary L. Skidmore,Jason Kunisaki,Yiing Lin,Kelsy C. Cotto,Erica K. Barnell,Jasreet Hundal,Kilannin Krysiak,Vincent Magrini,Lee Trani,Jason Walker,Robert S. Fulton,Elizabeth M. Brunt,Christopher A. Miller,Richard K. Wilson,Elaine R. Mardis,Malachi Griffith,William C. Chapman,Obi L. Griffith +17 more
TL;DR: In this paper , a comprehensive genome-and transcriptome-wide profiling approach was proposed to detect non-cirrhotic hepatocellular carcinoma (HCC) using genotoxic mutational signatures.
Journal ArticleDOI
Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement
Katherine E. Miller,Gregory L. Wheeler,Stephanie LaHaye,Kathleen M. Schieffer,Sydney Cearlock,Lakshmi Prakruthi Rao Venkata,A. Bravo,Olivia Grischow,Benjamin J. Kelly,Peter White,Christopher R. Pierson,Daniel R. Boue,Selene C. Koo,Darren Klawinski,Mark Ranalli,Ammar Shaikhouni,Ralph Salloum,Margaret Shatara,Jeffrey R. Leonard,Richard K. Wilson,Catherine E. Cottrell,Elaine R. Mardis,Daniel C. Koboldt +22 more
TL;DR: There may be clinical value in comprehensive molecular profiling in patients with multiple rhabdoid tumors, particularly given the potential prognostic and therapeutic implications for different rhabDoid tumor subgroups demonstrated in recent clinical trials and other large cohort studies.
Posted ContentDOI
Samovar: Single-sample mosaic SNV calling with linked reads
Charlotte A. Darby,James Fitch,Patrick J. Brennan,Benjamin J. Kelly,Natalie Bir,Vincent Magrini,Vincent Magrini,Jeffrey R. Leonard,Jeffrey R. Leonard,Catherine E. Cottrell,Catherine E. Cottrell,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Richard K. Wilson,Richard K. Wilson,Elaine R. Mardis,Elaine R. Mardis,Peter White,Peter White,Ben Langmead,Michael C. Schatz,Michael C. Schatz +21 more
TL;DR: Samovar is presented, a mosaic single-nucleotide variant (SNV) caller for linked-read whole-genome shotgun sequencing data and shown to outperform single-sample mosaic variant callers at MAF 5%-50% with at least 30x coverage.
Journal ArticleDOI
Expanding the clinical phenotype of FGFR1 internal tandem duplication
Esko A. Kautto,Kathleen M. Schieffer,Sean McGrath,Anthony R. Miller,Maria Elena Hernandez Gonzalez,Samantha Choi,Miriam R Conces,Esteban Fernandez-Faith,Mai-Lan Ho,Kristy Lee,Anna P. Lillis,Gregory D. Pearson,Stephen G. Kaler,Richard K. Wilson,Elaine R. Mardis,Vincent Magrini,Jeffrey R. Leonard,Catherine E. Cottrell +17 more
TL;DR: Through comprehensive molecular profiling of the intraspinal lesion and contiguous skin lesion, an internal tandem duplication (ITD) of the kinase domain of the fibroblast growth factor receptor 1 (FGFR1) gene was found and broadens the phenotypic spectrum of somatic mosaic FGFR1-related disease.