Richard K. Wilson

TL;DR: It is asserted that the collected updates in GRCh38 make the newer assembly a more robust substrate for comprehensive analyses that will promote the understanding of human biology and advance the efforts to improve health.

TL;DR: Comparisons of a subset of the data with nonredundant human mRNA and protein data bases show that the ESTs represent many known sequences and contain many that are novel, which supports the contention that although normalization reduces significantly the relative abundance of redundant cDNA clones, it does not result in the complete removal of members of gene families.

TL;DR: The complete nucleotide sequence of AZFc was determined by identifying and distinguishing between near-identical amplicons (massive repeat units) using an iterative mapping–sequencing process.

TL;DR: Patients with AML and MDS who had cytogenetic abnormalities associated with unfavorable risk, TP53 mutations, or both had favorable clinical responses and robust (but incomplete) mutation clearance after receiving serial 10-day courses of decitabine.

TL;DR: The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.