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Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Whole-genome sequencing and variant discovery in C. elegans.
LaDeana W. Hillier,Gabor T. Marth,Aaron R. Quinlan,David J. Dooling,Ginger A. Fewell,Derek Barnett,Paul Fox,Jarret Glasscock,Matthew T. Hickenbotham,Weichun Huang,Vincent Magrini,Ryan Richt,Sacha N. Sander,Donald A. Stewart,Michael Strömberg,Eric F. Tsung,Todd Wylie,Tim Schedl,Richard K. Wilson,Elaine R. Mardis +19 more
TL;DR: This study sequenced a Caernohabditis elegans N2 Bristol strain isolate and compared the reads to the reference genome to characterize the data and to evaluate coverage and representation, demonstrating the utility of massively parallel short read sequencing for whole genome resequencing and for accurate discovery of genome-wide polymorphisms.
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A novel retinoblastoma therapy from genomic and epigenetic analyses
Jinghui Zhang,Claudia A. Benavente,Justina McEvoy,Jacqueline Flores-Otero,Li Ding,Xiang Chen,Anatoly Ulyanov,Gang Wu,Matthew W. Wilson,Matthew W. Wilson,Jianmin Wang,Rachel C. Brennan,Michael Rusch,Amity L. Manning,Jing Ma,John Easton,Sheila A. Shurtleff,Charles G. Mullighan,Stanley Pounds,Suraj Mukatira,Pankaj Gupta,Geoff Neale,David Zhao,Charles Lu,Robert S. Fulton,Lucinda Fulton,Xin Hong,David J. Dooling,Kerri Ochoa,Clayton W. Naeve,Nicholas J. Dyson,Elaine R. Mardis,Armita Bahrami,David H. Ellison,Richard K. Wilson,James R. Downing,Michael A. Dyer,Michael A. Dyer +37 more
TL;DR: It is shown that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated, and that the proto-oncogene SYK is upregulated in retinOBlastoma and is required for tumour cell survival.
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Viral discovery and sequence recovery using DNA microarrays.
David Wang,Anatoly Urisman,Yu-Tsueng Liu,Michael Springer,Thomas G. Ksiazek,Dean D. Erdman,Elaine R. Mardis,Matthew T. Hickenbotham,Vincent Magrini,James M. Eldred,J. Phillipe Latreille,Richard K. Wilson,Don Ganem,Joseph L. DeRisi +13 more
TL;DR: A DNA microarray-based platform for novel virus identification and characterization designed to detect a wide range of known viruses as well as novel members of existing viral families, which revealed the presence of a previously uncharacterized coronavirus in a viral isolate cultivated from a SARS patient.
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DGIdb: mining the druggable genome
Malachi Griffith,Obi L. Griffith,Adam C. Coffman,James V. Weible,Josh F McMichael,Nicholas C. Spies,James Koval,Indraniel Das,Matthew B. Callaway,James M. Eldred,Christopher A. Miller,Janakiraman Subramanian,Ramaswamy Govindan,Runjun D. Kumar,Ron Bose,Li Ding,Jason Walker,David E. Larson,David J. Dooling,Scott M. Smith,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson +22 more
TL;DR: The Drug-Gene Interaction database (DGIdb) provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes.
Journal ArticleDOI
High Throughput Fingerprint Analysis of Large-Insert Clones
Marco A. Marra,Tamara A. Kucaba,Nicole Dietrich,Eric D. Green,B. Brownstein,Richard K. Wilson,Ken M. McDonald,LaDeana W. Hillier,John Douglas Mcpherson,Robert H. Waterston +9 more
TL;DR: It is shown that the fingerprints are of sufficient quality to permit the construction of megabase-size contigs in defined regions of the human genome and it is anticipated that the high throughput and precision characteristic of the fingerprinting method will make it of general utility.