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Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
DNMT3A-Dependent DNA Methylation May Act As a Tumor Suppressor-Not a Tumor Promoter-during AML Progression
David H. Spencer,David A. Russler-Germain,Nichole M. Helton,Tamara Lamprecht,Marwan Shinawi,Peter Westervelt,Jacqueline E. Payton,Robert S. Fulton,Richard K. Wilson,Matthew J. Walter,Daniel C. Link,John F. DiPersio,Timothy J. Ley +12 more
TL;DR: The findings demonstrate that DNMT3AR882H-associated hypomethylated cells in pre-leukemic cells is maintained during AML progression, and that functional DNMT2A mediates abnormal CpG island hypermethylation in AML.
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LIN28 expression and function in medulloblastoma
TL;DR: In this paper , the expression and function of LIN28A and LIN28B in Medulloblastoma (MB) patients and cell lines were studied and the effect of inhibition on MB cell growth, metabolism and stemness was assessed.
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HIV-1 neutralizing antibodies display dual specificity for the primary and coreceptor binding sites and preferential recognition of fully-cleaved Env
Yuxing Li,Sijy O'Dell,Richard K. Wilson,Xueling Wu,Stephen D. Schmidt,Carl-Magnus Hogerkorp,Mark K. Louder,Nancy S. Longo,Christian Poulsen,Javier Guenaga,Bimal K. Chakrabarti,Nicole A. Doria-Rose,Mario Roederer,Mark Connors,John R. Mascola,Richard T. Wyatt +15 more
TL;DR: From the same patient sera, it was detected that there was also a fraction of potent nAbs specific for elements of the Env CoRbs by differential protein adsorption followed by neutralization analysis.
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Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia
Giridharan Ramsingh,Dong Shen,Tamara Lamprecht,Sharon Heath,Robert S. Fulton,Elaine R. Mardis,Li Ding,Peter Westervelt,John S. Welch,Matthew J. Walter,Timothy A. Graubert,John F. DiPersio,Timothy J. Ley,Richard K. Wilson,Daniel C. Link +14 more
TL;DR: The exposure of hematopoietic stem/progenitors cells (HSPCs) to this genotoxic stress is hypothesized to alter the number and spectrum of mutations that arise in t-AML, which accounts for 10–20% of all new cases of AML and its incidence is rising.
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Case Report And Review Of The Literature: Immune Dysregulation In A Large Familial Cohort Due To A Novel Pathogenic RELA Variant.
Kelsey Lecerf,Daniel C. Koboldt,Hye Sun Kuehn,Vijayakumar Jayaraman,Kristy Lee,Theresa Mihalic Mosher,Jennifer R Yonkof,Mariko Mori,Scott E. Hickey,Samuel J Franklin,Joanne Drew,Shoghik Akoghlanian,Vidya Sivaraman,Sergio D. Rosenzweig,Richard K. Wilson,Roshini S. Abraham +15 more
TL;DR: The clinical, immunological, and genetic evaluation of a large kindred to further expand identification of patients with autosomal dominant RELA deficiency, facilitating earlier diagnosis and intervention suggests that this variant is causal for the clinical phenotype in these patients.