T
Torben F. Ørntoft
Researcher at Aarhus University Hospital
Publications - 13
Citations - 1362
Torben F. Ørntoft is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 12, co-authored 13 publications receiving 1123 citations. Previous affiliations of Torben F. Ørntoft include Aarhus University.
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Journal ArticleDOI
A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
Hila Gingold,Disa Tehler,Nanna R. Christoffersen,Morten Muhlig Nielsen,Fazila Asmar,Susanne M. Kooistra,Nicolaj S. Christophersen,Lise Lotte Christensen,Michael Borre,Karina Dalsgaard Sørensen,Lars Dyrskjot Andersen,Claus L. Andersen,Esther Hulleman,Thomas Wurdinger,Elisabeth Ralfkiaer,Kristian Helin,Kirsten Grønbæk,Torben F. Ørntoft,Sebastian M. Waszak,Orna Dahan,Jakob Skou Pedersen,Anders H. Lund,Yitzhak Pilpel +22 more
TL;DR: The existence of two distinct translation programs that operate during proliferation and differentiation are described, suggesting the existence of transcriptional programs coordinating tRNA supply and demand.
Journal ArticleDOI
Comparative analysis of discrete exosome fractions obtained by differential centrifugation
Dennis K. Jeppesen,Michael Lykke Hvam,Bjarke Primdahl-Bengtson,Anders T. Boysen,Bradley Whitehead,Lars Dyrskjøt,Torben F. Ørntoft,Kenneth A. Howard,Marie Stampe Ostenfeld +8 more
TL;DR: Specific g-force/k factor usage during differential centrifugation greatly influences the purity and yield of exosomes.
Journal ArticleDOI
Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Marie Stampe Ostenfeld,Dennis K. Jeppesen,Jens R. Laurberg,Anders T. Boysen,Jesper B. Bramsen,Bjarke Primdal-Bengtson,An Hendrix,Philippe Lamy,Frederik Dagnæs-Hansen,Mads Rasmussen,Khan H. Bui,Niels Fristrup,Erik Ilsø Christensen,Iver Nordentoft,Jens Preben Morth,Jørgen Bjerggaard Jensen,Jakob Skou Pedersen,Martin Beck,Dan Theodorescu,Michael Borre,Kenneth A. Howard,Lars Dyrskjøt,Torben F. Ørntoft +22 more
TL;DR: It is suggested that exosome-mediated secretion of tumor-suppressor miRNA is selected during tumor progression as a mechanism to coordinate activation of a metastatic cascade.
Journal ArticleDOI
Common variant at 16p11.2 conferring risk of psychosis
Stacy Steinberg,S de Jong,Manuel Mattheisen,Manuel Mattheisen,Javier Costas,Ditte Demontis,Ditte Demontis,Stéphane Jamain,Olli Pietiläinen,Olli Pietiläinen,Kuang Lin,Sergi Papiol,Sergi Papiol,Johanna Huttenlocher,Engilbert Sigurdsson,Evangelos Vassos,Ina Giegling,René Breuer,Gillian Fraser,Neil Walker,Ingrid Melle,Srdjan Djurovic,Ingrid Agartz,Annamari Tuulio-Henriksson,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Line Olsen,Thomas Hansen,Andres Ingason,Matti Pirinen,E Strengman,David M. Hougaard,Torben F. Ørntoft,M Didriksen,M V Hollegaard,Merete Nordentoft,Merete Nordentoft,L Abramova,Kaleda Vg,Manuel Arrojo,Julio Sanjuán,Celso Arango,Bruno Etain,Frank Bellivier,Alexandre Méary,F. Schürhoff,Andrei Szöke,Michele Ribolsi,Valentina Magni,Alberto Siracusano,Swetlana Sperling,Moritz J. Rossner,Moritz J. Rossner,Claus Christiansen,Lambertus A. Kiemeney,Barbara Franke,L.H. van den Berg,Jan H. Veldink,Sarah Curran,Patrick Bolton,M Poot,Wouter G. Staal,Karola Rehnström,Karola Rehnström,Helena Kilpinen,Helena Kilpinen,Christine M. Freitag,Jobst Meyer,Patrik K. E. Magnusson,Evald Saemundsen,I Martsenkovsky,I Bikshaieva,I Martsenkovska,O Vashchenko,M Raleva,K Paketchieva,B Stefanovski,Naser Durmishi,M. Pejovic Milovancevic,D. Lecic Tosevski,Teimuraz Silagadze,N Naneishvili,N Mikeladze,Simon Surguladze,John B. Vincent,Anne Farmer,Philip B. Mitchell,Philip B. Mitchell,Adam Wright,Adam Wright,Peter R. Schofield,Peter R. Schofield,Janice M. Fullerton,Janice M. Fullerton,Grant W. Montgomery,Nicholas G. Martin,Ivo Alex Rubino,R. van Winkel,R. van Winkel,Gunter Kenis,M. De Hert,János Réthelyi,István Bitter,Lars Terenius,Erik G. Jönsson,S Bakker,J. Van Os,Assen Jablensky,Marion Leboyer,Elvira Bramon,John Powell,Robin M. Murray,Aiden Corvin,Michael Gill,Derek W. Morris,F A O'Neill,Kenneth S. Kendler,Brien P. Riley,Nicholas John Craddock,Michael John Owen,Michael Conlon O'Donovan,Unnur Thorsteinsdottir,Augustine Kong,Hannelore Ehrenreich,Hannelore Ehrenreich,Angel Carracedo,V Golimbet,Ole A. Andreassen,Anders D. Børglum,Anders D. Børglum,Anders D. Børglum,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Thomas Werge,Thomas Werge,Roel A. Ophoff,Roel A. Ophoff,Markus M. Nöthen,Marcella Rietschel,Sven Cichon,Mirella Ruggeri,Sarah Tosato,Aarno Palotie,D St Clair,Dan Rujescu,David A. Collier,Hreinn Stefansson,Kari Stefansson +150 more
TL;DR: Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association with schizophrenia and is located within a 593-kb region that substantially increases risk of psychosis when duplicated.
Journal ArticleDOI
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
Paula Lopez-Serra,Miguel Marcilla,Alberto Villanueva,Antonio Ramos-Fernández,Anna Palau,Lucía Leal,Jessica E. Wahi,Fernando Setien-Baranda,Karolina Szczesna,Catia Moutinho,Anna Martínez-Cardús,Holger Heyn,Juan Sandoval,Sara Puertas,August Vidal,Xavier Sanjuan,Eva Martinez-Balibrea,Francesc Viñals,Jose C. Perales,Jesper B. Bramsem,Torben F. Ørntoft,Claus L. Andersen,Josep Tabernero,Ultan McDermott,Matthew B. Boxer,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Juan Pablo Albar,Manel Esteller,Manel Esteller +29 more
TL;DR: The presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3) is demonstrated, a key gene in the endoplasmic reticulum-associated protein degradation pathway, in human tumours and highlights the tumour suppressor features of the gene.