S
Stephanie Moquin
Researcher at National Institutes of Health
Publications - 20
Citations - 3064
Stephanie Moquin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Epitope. The author has an hindex of 13, co-authored 15 publications receiving 2684 citations. Previous affiliations of Stephanie Moquin include University of New Mexico & University of California, San Francisco.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Jason S. McLellan,Marie Pancera,Chris Carrico,Jason Gorman,Jean-Philippe Julien,Reza Khayat,Robert K. Louder,Robert Pejchal,Mallika Sastry,Kaifan Dai,Sijy O'Dell,Nikita Patel,Syed Shahzad-ul-Hussan,Yongping Yang,Baoshan Zhang,Tongqing Zhou,Jiang Zhu,Jeffrey C. Boyington,Gwo-Yu Chuang,Devan Diwanji,Ivelin S. Georgiev,Young Do Kwon,Doyung Lee,Mark K. Louder,Stephanie Moquin,Stephen D. Schmidt,Zhi Yong Yang,Mattia Bonsignori,John A. Crump,John A. Crump,Saidi Kapiga,Noel E. Sam,Barton F. Haynes,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Laura M. Walker,Sanjay Phogat,Richard T. Wyatt,Jared Orwenyo,Lai-Xi Wang,James Arthos,Carole A. Bewley,John R. Mascola,Gary J. Nabel,William R. Schief,William R. Schief,Andrew B. Ward,Ian A. Wilson,Peter D. Kwong +49 more
TL;DR: The structure of V1/V2 in complex with PG9 is reported, identifying a paradigm of antibody recognition for highly glycosylated antigens, which—with PG9—involves a site of vulnerability comprising just two glycans and a strand.
Journal ArticleDOI
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Tongqing Zhou,Jiang Zhu,Xueling Wu,Stephanie Moquin,Baoshan Zhang,Priyamvada Acharya,Ivelin S. Georgiev,Han Altae-Tran,Gwo-Yu Chuang,M. Gordon Joyce,Young Do Kwon,Nancy S. Longo,Mark K. Louder,Timothy S. Luongo,Krisha McKee,Chaim A. Schramm,Jeff Skinner,Yongping Yang,Zhongjia Yang,Zhenhai Zhang,Anqi Zheng,Mattia Bonsignori,Barton F. Haynes,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Melissa Simek,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,James C. Mullikin,Mark Connors,Lawrence Shapiro,Lawrence Shapiro,Gary J. Nabel,John R. Mascola,Peter D. Kwong +36 more
TL;DR: Developmental similarities in multiple donors thus reveal the generation of VRC01-class antibodies to be reproducible in principle, thereby providing a framework for attempts to elicit similar antibodies in the general population.
Journal ArticleDOI
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
Tongqing Zhou,Rebecca M. Lynch,Lei Chen,Priyamvada Acharya,Xueling Wu,Nicole A. Doria-Rose,M. Gordon Joyce,Daniel Lingwood,Cinque Soto,Robert T. Bailer,Michael J. Ernandes,Rui Kong,Nancy S. Longo,Mark K. Louder,Krisha McKee,Sijy O'Dell,Stephen D. Schmidt,Lillian Tran,Zhongjia Yang,Aliaksandr Druz,Timothy S. Luongo,Stephanie Moquin,Sanjay Srivatsan,Yongping Yang,Baoshan Zhang,Anqi Zheng,Marie Pancera,Tatsiana Kirys,Ivelin S. Georgiev,Tatyana Gindin,Hung-Pin Peng,An-Suei Yang,James C. Mullikin,Matthew D. Gray,Leonidas Stamatatos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Myron S. Cohen,Barton F. Haynes,Joseph P. Casazza,Mark Connors,Davide Corti,Antonio Lanzavecchia,Quentin J. Sattentau,Robin A. Weiss,Anthony P. West,Pamela J. Bjorkman,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +54 more
TL;DR: The repertoire for effective recognition of the CD4 supersite thus comprises antibodies with distinct paratopes arrayed about two optimal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogeny.
Journal ArticleDOI
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Ivelin S. Georgiev,Nicole A. Doria-Rose,Tongqing Zhou,Young Do Kwon,Ryan P. Staupe,Stephanie Moquin,Gwo-Yu Chuang,Mark K. Louder,Stephen D. Schmidt,Han Altae-Tran,Robert T. Bailer,Krisha McKee,Martha Nason,Sijy O'Dell,Gilad Ofek,Marie Pancera,Sanjay Srivatsan,Lawrence Shapiro,Lawrence Shapiro,Mark Connors,Stephen A. Migueles,Lynn Morris,Lynn Morris,Yoshiaki Nishimura,Malcolm A. Martin,John R. Mascola,Peter D. Kwong +26 more
TL;DR: Serum characterization and antibody isolation are transforming the understanding of the humoral immune response to viral infection, and it is shown that epitope specificities of HIV-1–neutralizing antibodies in serum can be elucidated from the serum pattern of neutralization against a diverse panel ofAIDS-1 isolates.