T
Thomas Franz
Researcher at Max Planck Society
Publications - 18
Citations - 1423
Thomas Franz is an academic researcher from Max Planck Society. The author has contributed to research in topics: Erlotinib & Skeletal muscle. The author has an hindex of 12, co-authored 18 publications receiving 1237 citations.
Papers
More filters
Journal ArticleDOI
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Martin E. Hess,Simon Hess,Kate D. Meyer,Linda A W Verhagen,Linda Koch,Hella S. Brönneke,Marcelo O. Dietrich,Sabine D. Jordan,Yogesh Saletore,Olivier Elemento,Bengt F. Belgardt,Thomas Franz,Tamas L Horvath,Ulrich Rüther,Samie R. Jaffrey,Peter Kloppenburg,Jens C. Brüning +16 more
TL;DR: It is demonstrated that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses.
Journal ArticleDOI
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.
Michael Reuter,Shinichiro Chuma,Takashi Tanaka,Thomas Franz,Alexander Stark,Ramesh S. Pillai +5 more
TL;DR: This work isolated Mili-containing complexes from adult mouse testes and identified Tudor domain–containing protein-1 (Tdrd1) as a factor specifically associated with the Mili piRNP throughout spermatogenesis, suggesting that Tdrd 1 ensures the entry of correct transcripts into the normal piRNA pool.
Journal ArticleDOI
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
Yolanda Cámara,Jorge Asin-Cayuela,Chan Bae Park,Metodi D. Metodiev,Yonghong Shi,Yonghong Shi,Benedetta Ruzzenente,Christian Kukat,Bianca Habermann,Rolf Wibom,Kjell Hultenby,Thomas Franz,Hediye Erdjument-Bromage,Paul Tempst,B. Martin Hallberg,Claes M. Gustafsson,Nils-Göran Larsson,Nils-Göran Larsson +17 more
TL;DR: The results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria and directly controls mitochondrial ribosomal biogenesis and translation.
Journal ArticleDOI
Muscle RING-Finger Protein-1 (MuRF1) as a Connector of Muscle Energy Metabolism and Protein Synthesis
Suguru Koyama,Shoji Hata,Christian Witt,Yasuko Ono,Stefanie Lerche,Koichi Ojima,Tomoki Chiba,Naoko Doi,Fujiko Kitamura,Keiji Tanaka,Keiko Abe,Stephanie H. Witt,Vladimir Rybin,Alexander Gasch,Thomas Franz,Siegfried Labeit,Hiroyuki Sorimachi +16 more
TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.
Journal ArticleDOI
Secretome profiling of primary human skeletal muscle cells
Sonja Hartwig,Silja Raschke,Birgit Knebel,Mika Scheler,Martin Irmler,Waltraud Passlack,Stefan Müller,Franz-Georg Hanisch,Thomas Franz,Xinping Li,Hans-Dieter Dicken,Kristin Eckardt,Johannes Beckers,Martin Hrabé de Angelis,Cora Weigert,Hans-Ulrich Häring,Hadi Al-Hasani,D. Margriet Ouwens,Jürgen Eckel,Jorg Kotzka,Stefan Lehr +20 more
TL;DR: The present study aimed at characterizing the secretome of differentiated primary human skeletal muscle cells derived from healthy, adult donors combining three different mass spectrometry based non-targeted approaches as well as one antibody based method.