Thomas Franz

TL;DR: It is demonstrated that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses.

TL;DR: This work isolated Mili-containing complexes from adult mouse testes and identified Tudor domain–containing protein-1 (Tdrd1) as a factor specifically associated with the Mili piRNP throughout spermatogenesis, suggesting that Tdrd 1 ensures the entry of correct transcripts into the normal piRNA pool.

TL;DR: The results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria and directly controls mitochondrial ribosomal biogenesis and translation.

TL;DR: Data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in theregulation of ATP synthesis under metabolic-stress conditions where Mu RF1 expression is induced.

TL;DR: The present study aimed at characterizing the secretome of differentiated primary human skeletal muscle cells derived from healthy, adult donors combining three different mass spectrometry based non-targeted approaches as well as one antibody based method.