V
Vadim N. Gladyshev
Researcher at Brigham and Women's Hospital
Publications - 526
Citations - 40499
Vadim N. Gladyshev is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Selenoprotein & Selenocysteine. The author has an hindex of 102, co-authored 490 publications receiving 34148 citations. Previous affiliations of Vadim N. Gladyshev include Pompeu Fabra University & Howard Hughes Medical Institute.
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Journal ArticleDOI
The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Sabeeha S. Merchant,Simon E. Prochnik,Olivier Vallon,Elizabeth H. Harris,Steven J. Karpowicz,George B. Witman,Astrid Terry,Asaf Salamov,Lillian K. Fritz-Laylin,Laurence Maréchal-Drouard,Wallace F. Marshall,Liang-Hu Qu,David R. Nelson,Anton A. Sanderfoot,Martin H. Spalding,Vladimir V. Kapitonov,Qinghu Ren,Patrick J. Ferris,Erika Lindquist,Harris Shapiro,Susan Lucas,Jane Grimwood,Jeremy Schmutz,Pierre Cardol,Pierre Cardol,Heriberto Cerutti,Guillaume Chanfreau,Chun-Long Chen,Valérie Cognat,Martin T. Croft,Rachel M. Dent,Susan K. Dutcher,Emilio Fernández,Hideya Fukuzawa,David González-Ballester,Diego González-Halphen,Armin Hallmann,Marc Hanikenne,Michael Hippler,William Inwood,Kamel Jabbari,Ming Kalanon,Richard Kuras,Paul A. Lefebvre,Stéphane D. Lemaire,Alexey V. Lobanov,Martin Lohr,Andrea L Manuell,Iris Meier,Laurens Mets,Maria Mittag,Telsa M. Mittelmeier,James V. Moroney,Jeffrey L. Moseley,Carolyn A. Napoli,Aurora M. Nedelcu,Krishna K. Niyogi,Sergey V. Novoselov,Ian T. Paulsen,Greg Pazour,Saul Purton,Jean-Philippe Ral,Diego Mauricio Riaño-Pachón,Wayne R. Riekhof,Linda A. Rymarquis,Michael Schroda,David B. Stern,James G. Umen,Robert D. Willows,Nedra F. Wilson,Sara L. Zimmer,Jens Allmer,Janneke Balk,Katerina Bisova,Chong-Jian Chen,Marek Eliáš,Karla C Gendler,Charles R. Hauser,Mary Rose Lamb,Heidi K. Ledford,Joanne C. Long,Jun Minagawa,M. Dudley Page,Junmin Pan,Wirulda Pootakham,Sanja Roje,Annkatrin Rose,Eric Stahlberg,Aimee M. Terauchi,Pinfen Yang,Steven G. Ball,Chris Bowler,Carol L. Dieckmann,Vadim N. Gladyshev,Pamela J. Green,Richard A. Jorgensen,Stephen P. Mayfield,Bernd Mueller-Roeber,Sathish Rajamani,Richard T. Sayre,Peter Brokstein,Inna Dubchak,David Goodstein,Leila Hornick,Y. Wayne Huang,Jinal Jhaveri,Yigong Luo,Diego Martinez,Wing Chi Abby Ngau,Bobby Otillar,Alexander Poliakov,Aaron Porter,Lukasz Szajkowski,Gregory Werner,Kemin Zhou,Igor V. Grigoriev,Daniel S. Rokhsar,Daniel S. Rokhsar,Arthur R. Grossman +118 more
TL;DR: Analyses of the Chlamydomonas genome advance the understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Journal ArticleDOI
Characterization of Mammalian Selenoproteomes
Gregory V. Kryukov,Sergi Castellano,Sergey V. Novoselov,Sergey V. Novoselov,Alexey V. Lobanov,Alexey V. Lobanov,Omid Zehtab,Omid Zehtab,Roderic Guigó,Roderic Guigó,Vadim N. Gladyshev,Vadim N. Gladyshev +11 more
TL;DR: This work identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs.
Journal ArticleDOI
Selenoproteins: molecular pathways and physiological roles.
TL;DR: Current knowledge about how these unique proteins perform their functions at the molecular level is discussed and new insights into the roles that selenoproteins play in human health are highlighted.
Journal ArticleDOI
How selenium has altered our understanding of the genetic code.
TL;DR: While the fundamental mechanism of Sec insertion in these organisms appears to be similar, recent studies suggest that mammals evolved additional components that allow incorporation of multiple Secs into a single protein and provide stringent regulation of Sec biosynthesis.
Journal ArticleDOI
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Eun Bae Kim,Xiaodong Fang,Alexey A. Fushan,Zhiyong Huang,Alexei Lobanov,Lijuan Han,Stefano M. Marino,Xiaoqing Sun,Anton A. Turanov,Pengcheng Yang,Sun Hee Yim,Xiang Zhao,Marina V. Kasaikina,Nina Stoletzki,Chunfang Peng,Paz Polak,Zhiqiang Xiong,Adam Kiezun,Yabing Zhu,Yuanxin Chen,Gregory V. Kryukov,Qiang Zhang,Leonid Peshkin,Lan Yang,Roderick T. Bronson,Rochelle Buffenstein,Bo Wang,Changlei Han,Qiye Li,Li Chen,Wei Zhao,Shamil R. Sunyaev,Thomas J. Park,Guojie Zhang,Jun Wang,Vadim N. Gladyshev +35 more
TL;DR: The sequencing and analysis of the naked mole rat genome is reported, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing.