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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
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Journal ArticleDOI
Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
TL;DR: The sequence kernel association test (SKAT) is proposed, a supervised, flexible, computationally efficient regression method to test for association between genetic variants (common and rare) in a region and a continuous or dichotomous trait while easily adjusting for covariates.
Journal ArticleDOI
Quality of life and satisfaction with outcome among prostate-cancer survivors.
Martin G. Sanda,Rodney L. Dunn,Jeff M. Michalski,Howard M. Sandler,Laurel L. Northouse,Larry Hembroff,Xihong Lin,Thomas K. Greenfield,Mark S. Litwin,Mark S. Litwin,Christopher S. Saigal,Arul Mahadevan,Eric A. Klein,Adam S. Kibel,Louis L. Pisters,Deborah A. Kuban,Irving D. Kaplan,Darien Wood,Jay P. Ciezki,Nikhil L. Shah,John T. Wei +20 more
TL;DR: Each prostate-cancer treatment was associated with a distinct pattern of change in quality-of-life domains related to urinary, sexual, bowel, and hormonal function, and these changes influenced satisfaction with treatment outcomes among patients and their spouses or partners.
Journal ArticleDOI
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study.
Long H. Nguyen,David A. Drew,Mark S. Graham,Amit Joshi,Chuan Guo Guo,Chuan Guo Guo,Wenjie Ma,Raaj S. Mehta,Erica T. Warner,Daniel Sikavi,Chun-Han Lo,Sohee Kwon,Mingyang Song,Lorelei A. Mucci,Meir J. Stampfer,Walter C. Willett,A. Heather Eliassen,Jaime E. Hart,Jorge E. Chavarro,Janet W. Rich-Edwards,Richard Davies,Joan Capdevila,Karla A. Lee,Mary Ni Lochlainn,Thomas Varsavsky,Carole H. Sudre,M. Jorge Cardoso,Jonathan Wolf,Tim D. Spector,Sebastien Ourselin,Claire J. Steves,Andrew T. Chan,Christine M. Albert,Gabriella Andreotti,Bijal Bala,Bijal A. Balasubramanian,Laura Beane-Freeman,John S. Brownstein,Fiona Bruinsma,Joe Coresh,Rui Costa,Annie Cowan,Anusila Deka,Sandra Deming-Halverson,Maria Elena Martinez,Michael E. Ernst,Jane C. Figueiredo,Pedro Fortuna,Paul W. Franks,Laura E. Beane Freeman,Christopher D. Gardner,Irene M. Ghobrial,Christopher A. Haiman,Janet E. Hall,Jae H. Kang,Brenda Kirpach,Karestan C. Koenen,Laura D. Kubzansky,James V. Lacey,Loic Le Marchand,Xihong Lin,Pamela L. Lutsey,Catherine R. Marinac,Roger L. Milne,Anne M. Murray,Denis Nash,Julie R. Palmer,Alpa V. Patel,Eric Pierce,McKaylee Robertson,Lynn Rosenberg,Dale P. Sandler,Shepherd H. Schurman,Kara Sewalk,Shreela V. Sharma,Chris Sidey-Gibbons,Liz Slevin,Jordan W. Smoller,Maarit Tiirikainen,Scott T. Weiss,Lynne R. Wilkens,Feng Zhang +81 more
TL;DR: In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers, and adequacy of PPE, clinical setting, and ethnic background were also important factors.
Journal ArticleDOI
Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China.
An Pan,Li Liu,Chaolong Wang,Huan Guo,Xingjie Hao,Qi Wang,Jiao Huang,Na He,Hongjie Yu,Xihong Lin,Sheng Wei,Tangchun Wu +11 more
TL;DR: A series of multifaceted public health interventions was temporally associated with improved control of the COVID-19 outbreak in Wuhan, China, and may inform public health policy in other countries and regions.
Journal ArticleDOI
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji,Matthew R. Ramsey,D. Neil Hayes,Cheng Fan,Kate McNamara,Piotr Kozlowski,Chad Torrice,Michael C. Wu,Takeshi Shimamura,Samanthi A. Perera,Mei-Chih Liang,Dongpo Cai,George N. Naumov,Lei Bao,Cristina Contreras,Danan Li,Liang Chen,Janakiraman Krishnamurthy,Jussi Koivunen,Lucian R. Chirieac,Robert F. Padera,Roderick T. Bronson,Neal I. Lindeman,David C. Christiani,Xihong Lin,Geoffrey I. Shapiro,Pasi A. Jänne,Bruce E. Johnson,Matthew Meyerson,David J. Kwiatkowski,Diego H. Castrillon,Nabeel Bardeesy,Norman E. Sharpless,Kwok-Kin Wong +33 more
TL;DR: LKB1 is established as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis in lung cancer, and expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes as targets of LKB1 repression.