Institution
Banaras Hindu University
Education•Varanasi, Uttar Pradesh, India•
About: Banaras Hindu University is a education organization based out in Varanasi, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 11858 authors who have published 23917 publications receiving 464677 citations. The organization is also known as: Kashi Hindu Vishvavidyalay & Benares Hindu University.
Topics: Population, Catalysis, Dielectric, Alloy, Raman spectroscopy
Papers published on a yearly basis
Papers
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TL;DR: This report provides national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.
522 citations
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TL;DR: Isatin, its 5-chloro and 5-bromo derivatives have been reacted with N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and three secondary amines.
521 citations
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TL;DR: The present review summarizes uptake, translocation and accumulation of nanomaterials and their recognized ways of phytotoxicity on morpho-anatomical, physiological, biochemical and molecular traits of plants and examines the intrinsic detoxification mechanisms in plants in light ofnanomaterial accumulation within plant cells or parts.
521 citations
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TL;DR: In this article, the removal of Cu(II) by adsorption on fly ash has been found to be concentration, pH and temperature dependent, indicating the process to be diffusion controlled.
513 citations
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TL;DR: Observations in the laboratory reveal that absence or reduced levels of the developmentally active as well as stress induced non-coding hsrω transcripts, which are known to sequester diverse hnRNPs and related nuclear RNA-binding proteins, block induced apoptosis in Drosophila.
Abstract: Heat shock induced gene expression and other cellular responses help limit the damage caused by stress and thus facilitate cellular recovery. Cellular damage also triggers apoptotic cell death through several pathways. This paper briefl y reviews interactions of the major heat shock proteins with components of the apoptotic pathways. Hsp90, which acts as a chaperone for unstable signal transducers to keep them poised for activation, interacts with RIP and Akt and promotes NF-κB mediated inhibition of apoptosis; in addition it also blocks some steps in the apoptotic pathways. Hsp70 is mostly anti-apoptotic and acts at several levels like inhibition of translocation of Bax into mitochondria, release of cytochrome c from mitochondria, formation of apoptosome and inhibition of activation of initiator caspases. Hsp70 also modulates JNK, NF-κB and Akt signaling pathways in the apoptotic cascade. In contrast, Hsp60 has both anti- and pro-apoptotic roles. Cytosolic Hsp60 prevents translocation of the pro-apoptotic protein Bax into mitochondria and thus promotes cell survival but it also promotes maturation of procaspase-3, essential for caspase mediated cell death. Our recent in vivo studies show that RNAi for the Hsp60D in Drosophila melanogaster prevents induced apoptosis. Hsp27 exerts its anti-apoptotic infl uence by inhibiting cytochrome c and TNF-mediated cell death. αβ crystallin suppresses caspase-8 and cytochrome c mediated activation of caspase-3. Studies in our laboratory also reveal that absence or reduced levels of the developmentally active as well as stress induced non-coding hsrω transcripts, which are known to sequester diverse hnRNPs and related nuclear RNA-binding proteins, block induced apoptosis in Drosophila. Modulation of the apoptotic pathways by Hsps refl ects their roles as “weak links” between various “hubs” in cellular networks. On the other hand, non-coding RNAs, by virtue of their potential to bind with multiple proteins, can act as “hubs” in these networks. In view of the integrative nature of living systems, it is not surprising that stress-induced genes, generally believed to primarily function in cell survival pathways, inhibit or even promote cell death pathways at multiple levels to ensure homeostasis at cell and/or organism level. The heat shock genes obviously do much more than merely help cells survive stress.
499 citations
Authors
Showing all 12110 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ashok Kumar | 151 | 5654 | 164086 |
Rajesh Kumar | 149 | 4439 | 140830 |
Prashant Shukla | 131 | 1341 | 85287 |
Sudhir Malik | 130 | 1669 | 98522 |
Vijay P. Singh | 106 | 1699 | 55831 |
Rakesh Agrawal | 105 | 668 | 107569 |
Gautam Sethi | 102 | 425 | 31088 |
Jens Christian Frisvad | 99 | 453 | 31760 |
Sandeep Kumar | 94 | 1563 | 38652 |
E. De Clercq | 90 | 774 | 30296 |
Praveen Kumar | 88 | 1339 | 35718 |
Shyam Sundar | 86 | 614 | 30289 |
Arvind Kumar | 85 | 876 | 33484 |
Padma Kant Shukla | 84 | 1232 | 35521 |
Brajesh K. Singh | 83 | 401 | 24101 |