Institution
Connolly Hospital Blanchardstown
Healthcare•Dublin, Ireland•
About: Connolly Hospital Blanchardstown is a healthcare organization based out in Dublin, Ireland. It is known for research contribution in the topics: Population & Ambulatory blood pressure. The organization has 302 authors who have published 213 publications receiving 3858 citations. The organization is also known as: James Connolly Memorial Hospital.
Topics: Population, Ambulatory blood pressure, Stroke, Vitamin D and neurology, Staphylococcus aureus
Papers published on a yearly basis
Papers
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University of California, Los Angeles1, University of California, Berkeley2, Pontifícia Universidade Católica do Rio Grande do Sul3, Federal University of Ceará4, Sao Paulo State University5, University of Ioannina6, Mid-Western Regional Hospital7, Connolly Hospital Blanchardstown8, University of Genoa9, Vilnius University10, Utrecht University11, Rio de Janeiro State University12, University of Copenhagen13, Al-Azhar University14, Assiut University15, University of Tartu16, University of Paris17, University of Burgundy18, National and Kapodistrian University of Athens19, Charité20, Semmelweis University21, University of Pisa22, Catholic University of the Sacred Heart23, Marche Polytechnic University24, Lithuanian University of Health Sciences25, Medisch Spectrum Twente26, Medical University of Białystok27, Medical University of Lublin28, Russian Academy29, I.M. Sechenov First Moscow State Medical University30, Uppsala University31, Gazi University32, Istanbul University33, Imperial College Healthcare34, King's College London35, New York University36, Vanderbilt University37, University of Arkansas for Medical Sciences38
TL;DR: Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders, compared to the normal BMI range.
Abstract: OBJECTIVES: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. METHODS: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. RESULTS: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. CONCLUSIONS: BMI appears to be associated with RA disease activity in women, but not in men.
60 citations
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TL;DR: The EHI identified patients with resolution of endoscopic disease activity, with good overall accuracy, although with variation between the 2 cohorts assessed, and might be used in practice for assessing endoscopic activity in patients with CD.
57 citations
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TL;DR: A reduction of calpain activity in islet could contribute to the development of beta-cell failure in type 2 diabetes thereby providing a link between genetic susceptibility to diabetes and the pathophysiologic manifestations of the disease.
Abstract: Genetic variation in the gene for a cytosolic cysteine protease, calpain-10, increases the susceptibility to type 2 diabetes apparently by altering levels of gene expression. In view of the importance of altered beta-cell function in the pathophysiology of type 2 diabetes, the present study was undertaken to define the effects on insulin secretion of exposing pancreatic islets to calpain inhibitors for 48 hours. Exposure of mouse islets to calpain inhibitors (ALLN, ALLM, E-64-d, MDL 18270, and PD147631) of different structure and mechanism of action for 48 hours reversibly suppresses glucose-induced insulin secretion by 40% to 80%. Exposure of islets to inhibitors of other proteases, ie, cathepsin B and proteasome, did not affect insulin secretion. The 48-hour incubation with calpain inhibitors also attenuates insulin secretory responses to the mitochondrial fuel alpha-ketoisocaproate (KIC). The same incubation also suppresses glucose metabolism and intracellular calcium ([Ca(2+)](i)) responses to glucose or KIC in islets. In summary, long-term inhibition of islet calpain activity attenuates insulin secretion possibly by limiting the rate of glucose metabolism. A reduction of calpain activity in islet could contribute to the development of beta-cell failure in type 2 diabetes thereby providing a link between genetic susceptibility to diabetes and the pathophysiologic manifestations of the disease.
56 citations
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University of Amsterdam1, Netherlands Cancer Institute2, VU University Amsterdam3, Catharina Ziekenhuis4, University Medical Center Utrecht5, Erasmus University Rotterdam6, Karolinska Institutet7, Katholieke Universiteit Leuven8, Humanitas University9, University of Milan10, University of Verona11, University of Bologna12, Royal Victoria Infirmary13, The Royal Marsden NHS Foundation Trust14, University of Oxford15, Norfolk and Norwich University Hospital16, Imperial College London17, Connolly Hospital Blanchardstown18, Trinity College, Dublin19, Showa University20, Chiba University21, Niigata University22, Fudan University23, University of Hong Kong24, University of Texas MD Anderson Cancer Center25, Virginia Mason Medical Center26, Mayo Clinic27, University of Toronto28, University of Mainz29
TL;DR: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph nodes metastases, pre-operative diagnostics, neo-adjuvant therapy and survival.
Abstract: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients. The TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival. The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics. NCT03222895
, date of registration: July 19th, 2017.
51 citations
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TL;DR: Percutaneous iliac arteriovenous fistula creation for COPD causes a significant and persistent lowering of blood pressure in patients with co-existing hypertension.
50 citations
Authors
Showing all 303 results
Name | H-index | Papers | Citations |
---|---|---|---|
James P. O'Gara | 41 | 87 | 5924 |
Jarushka Naidoo | 38 | 139 | 7798 |
Thomas N. Walsh | 31 | 127 | 4735 |
Richard J. Farrell | 31 | 91 | 5176 |
Conor Burke | 26 | 65 | 2968 |
Seamus Sreenan | 24 | 73 | 2667 |
Eamon Dolan | 24 | 61 | 1728 |
Cathal J. Kelly | 22 | 56 | 1183 |
John Faul | 22 | 41 | 2163 |
Eoghan O'Neill | 19 | 45 | 1996 |
Austin Leahy | 19 | 83 | 1385 |
Aoife M. Egan | 18 | 73 | 1173 |
James M. O’Riordan | 17 | 48 | 1294 |
Conor P Kerley | 14 | 27 | 450 |
John H. McDermott | 13 | 31 | 474 |