Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Catalytic C-H Bond Activation and Knoevenagel Condensation Using Pyridine-2,3-Dicarboxylate-Based Metal-Organic Frameworks.

Abstract: Three 1D coordination polymers (CPs) [M(pdca)(H2O)2] n (M = Zn, Cd, and Co; 1-3), and a 3D coordination framework {[(CH3)2NH2][CuK(2,3-pdca)(pa)(NO3)2]} n (4) (2,3-pdca = pyridine-2,3-dicarboxylate and pa = picolinic acid), have been synthesized adopting a solvothermal reaction strategy. The CPs have been thoroughly characterized using various spectral techniques, that is, elemental analyses, FT-IR, TGA, DSC, UV/vis, and luminescence. Structural information on 1-4 was obtained by PXRD and X-ray single-crystal analyses, whereas morphological insights were attained through FESEM, AFM, EDX, HRTEM, and BET surface area analyses. Roughness parameters were calculated from AFM analysis, whereas dimensions of small domains and interplanar spacing were defined with the aid of HRTEM. CPs 1-3 are 1D isostructural networks, whereas 4 is a 3D framework. Moreover, 1-4 display moderate luminescence at rt. In addition, 1-4 have been applied as economic and efficient porous catalysts for the Knoevenagel condensation reaction and C-H bond activation under mild conditions with good yields (95-98 and 97-99%), respectively. Notably, 1-3 can be reused up to seven cycles, whereas 4 can be reused up to five catalytic cycles with retained catalytic efficiency. Relative catalytic efficacy toward the Knoevenagel condensation reaction follows in the order 2 > 1 > 3 > 4, whereas 2 > 4 > 1 > 3 for C-H activation. The present result demonstrates synthetic, structural, optical, morphological, and catalytic aspects of 1-4.

Albumin nanoparticles coated with polysorbate 80 for the targeted delivery of antiepileptic drug levetiracetam into the brain.

Abstract: The aim of the study was to target levetiracetam (LEV) into the brain by albumin nanoparticles. The levetiracetam-loaded albumin nanoparticles (LEV-NPs) were formulated by desolvation. The particle size of LEV-NPs was 153.7 ± 44.8 nm and the zeta potential was − 10.8 mV. The in vitro LEV release, in pH 6.8 phosphate buffer, was determined by dialysis and showed a biphasic pattern of drug release and ranged in between 40.42 ± 2.6% w/w and 63.61 ± 2.12% w/w. The biodistribution study was conducted on male Wistar rats. The LEV was given as i.v. injection in tail vein, and the formulations were the free drug, LEV-NPs, and levetiracetam-loaded albumin nanoparticles further coated with 1% polysorbate 80 (LEV-NPs-PS 80). A significant increase in LEV concentration was achieved in the brain for LEV-NPs-PS 80 when compared with LEV free drug. The LEV concentration achieved in the brain after administering free drug and LEV-NPs-PS 80 was 5.28 ± 1.79 and 18.54 ± 2.38 μg/gm respectively. The LEV-NPs-PS 80 enhanced LEV concentration in the brain by 3.51-fold when compared with the free drug.

IoT Based Healthcare Monitoring System Using 5G Communication and Machine Learning Models

Abstract: This chapter presents a smart healthcare monitoring system for patients by implanting wireless sensors on the body which collect different vital physiological parameters such as heart rate, blood pressure, body temperature, glucose level etc. The sensors are controlled by the Internet of Things devices and communicate the patient’s health record to the monitoring station using 5G services. This 5G service helps to enable the immediate treatment for the critical patient with no time. In addition, the rate of detection of the critical condition of the patient is enhanced with the application of machine learning models for better and efficient prediction. Therefore, the improvement of healthcare monitoring system enhances human life value by integrating advanced and cutting edge technologies as a consequence of which the frequent visit of patients to the hospitals or emergency units can be reduced.

Oral Insulin: Myth or Reality

Abstract: Background Diabetes Mellitus (DM) is a disorder of glucose metabolism marked by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and ketonaemia. DM is a major healthcare problems today and its treatment costs billions of dollars worldwide annually. The cases of diabetes have increased rapidly in recent years throughout the world. Currently, for the management of Type-1 Diabetes Mellitus (TIDM), Multiple Daily Insulin (MDI) injections is the most popular treatment. Oral administration of insulin is the most suitable and attractive as compared to subcutaneous route but unfortunately cannot be utilized for the administration of peptides and proteins due to poor epithelial permeability and enzymatic degradation within the gastrointestinal tract. Since many years, extensive research has been carried out to explore the potential ways of insulin administration based on novel methods such as liposome, microsphere, nanoparticle, mouth dissolving strips, sprays exploiting oral and pulmonary route. These next generation efficient therapies for T1DM may help to improve the quality of life of diabetic patients especially in Insulin Dependent Diabetes Mellitus (IDDM). Conclusion This review emphasizes on the most recent progress made in the development of oral insulin delivery formulations, and focuses on key lessons and implications from studies undertaken till date with the oral insulin formulations. Further, this review analyzes effectiveness of the advancements, applications and limitations of the technologies in delivering insulin to the targeted site through oral administration.

Antimicrobial activity of the essential oil of thuja orientalis L.

Abstract: The essential oil from seed coats of Thuja orientalis L. (Family cupressaceae) obtained in an yield of 1% has been studied for its antimicrobial activity against 6 bacteria and 5 fungi using filter paper disc agar diffusion technique. The oil has shown good to moderate activity of the oil against all six test bacteria. The activity of the oil against S. typhi has been found remarkable at 1:1000 dilutions. The activity against the fungal organisms at dilutions is moderate.