Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Bacterial invertases: Occurrence, production, biochemical characterization, and significance of transfructosylation

Abstract: Invertase or β-D-fructofuranoside fructohydrolase (EC 3.2.1.26) was one of the foremost enzyme biocatalysts and established the primary concepts of most enzyme-kinetic principles. Invertases are glycoside hydrolases and occur mostly in microorganisms. Among microbial strains, for many decades yeast species have been extensively researched for invertase production, characterization, and applications in industries. Besides, limited literature is available on invertases from bacterial strains. The enzymic and molecular biological reports from bacterial invertases are scarce. In this minireview, occurrence, production, biochemical properties, and significance of transfructosylation of bacterial invertases are reported.

Suppression of agglomeration of ciprofloxacin-loaded human serum albumin nanoparticles.

Abstract: The present study is aimed at developing and exploring the use of pectin in suppression of agglomeration of ciprofloxacinloaded human serum albumin (HSA) nanoparticles. The HSA-pectin nanoparticles loaded with ciprofloxacin were prepared by the pH-coacervation method, and various physicochemical parameters such as particle size, morphology, ζ-potential, electrolyte-induced flocculation, pH-dependent ζ-potential, drug loading, in vitro drug release, and stability of nanoparticles, were evaluated. The size of the HSA-pectin nanoparticles (F3) was found to be 180 to 290 nm. The HSA nanoparticles were modified with pectin when the critical flocculation concentration of nanoparticles in Na2SO4 solution was increased from 0.3 M to 0.9 M. The isoelectric points of the formed nanoparticles were found to be relatively lower between pH values 3 and 6. Pectin may be used as a pharmaceutical additive for the suppression of particle agglomeration in HSA nanoparticles, and the effect may be attributed to the pectin segments present on the surface of nanoparticles.

Effect of Some Vajikaran Herbs on Pendiculation Activities and In vitro Sperm Count in Male

Abstract: Ayurveda holds a special position amongst the various traditional systems of medicine. Vajikaran is a speciality in Ayurvedic system of medicine in India dealing with herbs possessing rejuvenative and revitalizing properties for improving sexual dynamics. In the present study, the effect of five vajikaran herbs on pendiculatory activity and in-vitro sperm count was assessed. The lyophilized aqueous extracts of Asparagus racemosus Willd., Chlorophytum borivilianum Sant. F., Curculigo orchioides Gaertn., Dactylorhiza hatagirea (D. Don) Soo and Orchis latifolia Linn.(200 mg/Kg b.w.) were administered orally to wistar strain male albino rats. Following this the effect of all the five drugs was evaluated for pendiculatory activity. The effect of extract on in-vitro sperm count was also assessed in a separate experiment where the initial sperm count and count after 30 min of incubation was determined. The results show that the herbs could significantly (P < 0.05) improve the pendiculatory activity in male rats after 14 days of treatment. Similarly, the extract could also preserve the in-vitro sperm count significantly when compared to control group after 30 min. of incubation. Hence the present study further supports the use of these plants as vajikaran or aphrodisiac in traditional Indian medicine.