Institution
Dr. Hari Singh Gour University
Education•Saugor, Madhya Pradesh, India•
About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.
Topics: Drug delivery, Computer science, Drug carrier, Liposome, Transdermal
Papers published on a yearly basis
Papers
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TL;DR: NLCs and SLNs have shown a good ability to increase drug accumulation in the various skin layers but NLCs may be a more potential carrier for topical delivery of capsaicin for an effective therapy of psoriasis.
Abstract: The study aims to explore the potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) in improving the topical delivery of capsaicin (CAP) by in vitro and in vivo studies. The lipidic nanoparticles were prepared by solvent diffusion method and were characterized for average particle size, zeta potential and entrapment efficiency. TEM photomicrographs revealed that the particles were nanometric in size. Higher amount of CAP can be encapsulated in the NLCs (87.4 ± 3.28) as compared with SLNs (79.7 ± 2.93%). The cumulative amounts of CAP permeated through the skin and retained in the SC were higher in the case of NLCs as compared with plain drug solution and SLNs. SLNs and NLCs exhibited minimum to no irritation. All the results concluded that NLCs and SLNs have shown a good ability to increase drug accumulation in the various skin layers but NLCs may be a more potential carrier for topical delivery of CAP for an effective therapy of psoriasis.
64 citations
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TL;DR: The present 3D-QSAR study attempts to explore the structural requirements of thiazolidinone derivatives for anti-HIV activity and shows that the steric and electrostatic properties predicted by CoMFA contours and the hydrogen bond acceptor, hydrogen bond donor, and hydrophobic properties predictedby CoMSIA contours are related to anti-hIV activity.
64 citations
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TL;DR: The present results suggest the potential of NLCs as a novel carrier for the dermal delivery of ADA and also the synergistic effect of vitamin C in topical therapeutics.
Abstract: The present study documents the fabrication and characterization of a topically applicable gel loaded with nanostructured lipid carriers (NLCs) of adapalene (ADA) and vitamin C (ascorbyl-6-palmitate [AP]). The NLCs were prepared by high pressure homogenization (HPH) method followed by incorporation into AP loaded gel. The fabricated system was characterized for size, poly dispersity index, entrapment efficiency (EE) and in vitro drug release properties, and was further investigated for skin compliance, skin transport characteristics (skin permeation and bio-distribution), rheological behavior, texture profile analysis and anti-acne therapeutic potential against testosterone-induced acne in male Wistar rats. The NLC-based formulation improved targeting of the skin epidermal layer and reducing systemic penetration. The co-administration of vitamin C led to an adjunct effect in acne therapy in physiological conditions. In brief, the present results suggest the potential of NLCs as a novel carrier for the dermal delivery of ADA and also the synergistic effect of vitamin C in topical therapeutics.
63 citations
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TL;DR: A series of neodymium ions activated yttrium aluminate nanophosphors of various concentrations were synthesized by solution combustion method using oxalyl dihydrazide as a fuel.
63 citations
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TL;DR: The different strategies for the design and synthesis of diverse biomolecule-embedded MOFs for various sensing techniques are described, including optical, electrochemical, biological, and miscellaneous techniques.
63 citations
Authors
Showing all 1166 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rajat Gupta | 126 | 1240 | 72881 |
Sanjay Jain | 103 | 881 | 46880 |
Ashwani Kumar | 66 | 703 | 18099 |
Narendra K. Jain | 59 | 154 | 9342 |
Suresh P. Vyas | 53 | 182 | 8479 |
Sanyog Jain | 52 | 276 | 8843 |
Prashant Kesharwani | 49 | 232 | 8043 |
Amit K. Goyal | 47 | 157 | 5749 |
Rakesh K. Tekade | 45 | 181 | 5927 |
James P. Stables | 44 | 146 | 6094 |
Vinod Kumar Dixit | 36 | 104 | 3827 |
Umesh Gupta | 34 | 96 | 4541 |
Swarnlata Saraf | 33 | 161 | 4943 |
Govind P. Agrawal | 32 | 59 | 2909 |
Vikas Sharma | 31 | 145 | 3720 |