Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Synthesis, characterization and antimicrobial activities of benzothiazole-imino-benzoic acid ligands and their Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes

Abstract: A couple of benzothiazole-imino-benzoic acid Schiff Bases namely (E)-2-((benzo[d]thiazol-2-ylimino)methyl)benzoic acid and (E)-2-(((5nitrobenzo[d]thiazol-2-yl)imino)methyl)-benzoic acid, derived from amino-benzothiazole, 2-formylbenzoic acid. A series of complexes with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions based on these ligands, have been synthesized and characterized through elemental analyses, FT-IR, NMR, UV/vis and mass spectroscopy. The preparation of ligands as well as their metal complexes has been accomplished under mild conditions with reasonably good to high yields. These complexes are obtained through complete precipitation which led to their easy separation and optimum purity. Both the ligands and complexes show good antimicrobial activity against human epidemic causing bacterial strains (1143) which causes infection in mouth, lungs breast, gastrointestinal tract (4300) and nosocomial infections (741).

Polymeric nanomedicines as a promising vehicle for solid tumor therapy and targeting

Abstract: Inspite of demanding research that has been undertaken for cancer treatment, cancer is a major cause of mortality. Available conventional treatment options of solid tumor are associated with serious side effects. Nanomedicines mediated fascinating approach may be effectively utilized for efficient tumor targeting by avoiding all the problems associated with conventional chemotherapy. Polymeric nanomedicines such as polymer micelles, polymeric nanoparticles, polymersomes and polymer conjugates currently developed for solid tumor treatment have proved to be efficacious cancer therapeutics. These polymeric nanostructures are able to reach tumor tissue or angiogenic endothelial cells either passively or actively. To date, more advancement in the tumor targeting field includes stimuli sensitive polymeric nanocarriers that pass through the intracellular delivery barriers and release the bioactives in response to the microenvironmental trigger of tumor cell. This review discusses the molecular aspects of solid tumor pathophysiology and its dramatic impact on research for innovative and novel therapeutic approaches linked with tumor-targeting polymeric nanomedicines.