Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Engineered human erythrocytes as carriers for ciprofloxacin

Abstract: Ciprofloxacin (CFX), a broad-spectrum antibacterial agent, was loaded into human erythrocytes by a method based on hypotonic preswelling, hemolysis, isotonic resealing, and reannealing. Various parameters such as volume of aqueous drug solution added, drug concentration, and temperature were optimized to obtain maximum loading of drug into erythrocytes. The loaded cells were characterized for drug content, hemoglobin content, percent cell recovery, morphology, osmotic fragility, turbulence shock, and in vitro drug as well as hemoglobin efflux. No appreciable detrimental effects on cell morphology, osmotic fragility, and turbulence shock in comparison with normal cells were noted. Osmotic fragility and turbulence shock studies indicated that the loaded erythrocytes are less resistant than the normal erythrocytes. Glutaraldehyde treatment stabilized both types of cells with respect to drug and hemoglobin release, osmotic fragility, and turbulence fragility. The studies suggest the potential of CFX-l...

A Review on Mechanical and Tribological Behaviors of Nickel Matrix Composites

Abstract: This paper presents a review on the behaviour of mechanical and tribological properties of Nickel matrix composites developed by using different process. Nickel and Nickel containing base alloys are identified as an invaluable and indispensable material over a wide range of industrial application due to its outstanding properties like good mechanical property, resistance to chemicals and to handle complex process. So there has been steadily increasing demand for such material to exhibit high performance in their mechanical and tribological properties in different applications. Development of such newer materials with better performance for mechanical and tribological applications has made researchers to come out with innovative and novel materials to be fabricated from conceptual methods. Metal matrix composites provide advantage over the development as they are particularly suited for applications requiring good strength at high temperature, good structural rigidity, dimensional stability, and light weight. This composites material also offer a combination of resistant to corrosion, thermal fatigue, thermal shock, strength, toughness, metallurgical stability, fabricability, weldability and also their ability to withstand a wide variety of severe operating conditions involving high temperatures, high stresses as well as creep. Many researchers have shown that reinforcements like oxides of silicon, graphene, alumina particulate; silicon carbide particles, tungsten, graphite etc. can easily be incorporated into Nickel matrix for the development of composites. High performance nickel and nickel alloy are very widely used in steel making, marine, aerospace, defense, automotive, construction, computers etc.

Coated chitosan nanoparticles encapsulating caspase 3 activator for effective treatment of colorectral cancer

Abstract: Cancer is the second leading cause of death worldwide, the deaths are projected to continue rising, with an estimated 12 million deaths in 2030. The aim of the present investigation is to prepare and compare the uncoated (U-CH NP) and eudragit S 100-coated (E-U-CH NP) chitosan nanoparticles encapsulating a caspase 3 activator (UCN 01), by ionic gelation method. The prepared formulations were studied for various parameters like particles size, zeta potential, transmission electron microscopy, atomic force microscopy, in vitro release study, ex vivo study using Caco 2 colon cancer cell line, and in vivo studies. The particle size and zeta potential of developed formulation was found to be particle size of 168 ± 3.7 nm and +35.8 ± 3.7 for U-CH NP and 265 ± 4.1 nm and +22.3 ± 1.1 for E-U-CH NP. TEM and AFM images revealed that U-CH NPs were round in shape and smoother at surface as compared to E-U-CH NP which have irregular surface due to coating. The E-U-CH NP showed better in vitro release than uncoated formulation in SCF (pH 6.8) than in SGF (pH 1.2). The cytotoxicity was performed by MTT assay. U-CH NP showed enhanced cytotoxicity as compared to blank (without drug) formulation. There was an increase in caspase 3 activity of U-CH NP as compared to UCN 01 alone. E-U-CH NP showed better tumor regression ability than U-CH NP. The results of plasma profile and tumor regression study demonstrated that E-U-CH NP has continuous release profile of UCN 01 and comprehensive residence time. Thus, it is better acceptable than free UCN 01 and may be a potential delivery system for the targeting and treatment of colon cancer.

Some Novel 2-Methyl-3-(1′,3′,4′-thiadiazoyl)-4-(3H)quinazolinones with Anticonvulsant and CNS Depressant Activity.

Abstract: A series comprising six novel 2-methyl-3-(l'3'4'-thiadiazoyl)-4(3H)quinazolinones have been synthesized by condensing different 2-amino-l,3,4-thiadiazoles with 2-methyl benzoxazin-2-one and evaluated for anticonvulsant and CNS depressant activity. Compound 5f exhibited both anticonvulsant and CNS depressant activity.

Y chromosome haplogroup distribution in Indo-European speaking tribes of Gujarat, western India.

Abstract: The present study was carried out in the Indo-European speaking tribal population groups of Southern Gujarat, India to investigate and reconstruct their paternal population structure and population histories. The role of language, ethnicity and geography in determining the observed pattern of Y haplogroup clustering in the study populations was also examined. A set of 48 bi-allelic markers on the non-recombining region of Y chromosome (NRY) were analysed in 284 males; representing nine Indo-European speaking tribal populations. The genetic structure of the populations revealed that none of these groups was overtly admixed or completely isolated. However, elevated haplogroup diversity and FST value point towards greater diversity and differentiation which suggests the possibility of early demographic expansion of the study groups. The phylogenetic analysis revealed 13 paternal lineages, of which six haplogroups: C5, H1a*, H2, J2, R1a1* and R2 accounted for a major portion of the Y chromosome diversity. The higher frequency of the six haplogroups and the pattern of clustering in the populations indicated overlapping of haplogroups with West and Central Asian populations. Other analyses undertaken on the population affiliations revealed that the Indo-European speaking populations along with the Dravidian speaking groups of southern India have an influence on the tribal groups of Gujarat. The vital role of geography in determining the distribution of Y lineages was also noticed. This implies that although language plays a vital role in determining the distribution of Y lineages, the present day linguistic affiliation of any population in India for reconstructing the demographic history of the country should be considered with caution.