Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Mitigating Byzantine Failures in Multi-agent based Dependable and Adaptable Avionics Software

Abstract: With increase in air traffic year on year and recent advancements and proliferation of unmanned aircraft systems, there is an increased drive and pressure to provide efficient and collaborative systems that leverage actionable information available on these ariel platforms. Adaptive systems forming the backbone of such platforms and adaptivity engineered through intelligent software agents is an attractive proposition as these ariel platforms operate in increasingly connected environments along with a number of other onboard systems collaboratively. This environment poses risks and a new set of problems wherein the adaptive system engineered with agents could fail, since some of these agents could be malicious. Byzantine faults form an important class of problems, contributing to these failures. Since the domain of avionics encompasses mission, safety, and flight critical systems, we provide one scheme that forms the basic block providing fault tolerance for byzantine failures caused by a single entity. A second scheme uses concepts from the signal-processing domain to over-come byzantine failures that involve multiple masquerading agents. We discuss the incorporation of these schemes in an exemplar adaptive flight planning system and provide reasoning for their correctness.

Macrophage targeting: a strategy for leishmaniasis specific delivery

Abstract: Leishmaniasis is a vector-borne zoonotic infection caused by an obligate intra macrophage protozoan parasite ‘ Leishmania ’. Despite of a number of remedies available, leishmaniasis is still a speedy migrating and deadly infection due to the resistance of the parasite to the drugs as well as their toxicity. Hence, there is a need for targeted drug delivery system for enhancing the systematic effect of antileishmanial drugs. Although the number of antileishmanial drugs in a variety of dosage forms is available, there is an urgency to develop more efficient, cost-effective and safe therapy, which can be achieved by macrophage targeting utilizing passive (phagocytosis), and/or active (receptor mediated) strategies utilizing nano-formulations. Positive considerations of various factors like the enhanced permeation and retention (EPR) effect, size, and charge of nano-formulations can facilitate the passive targeting, and various receptors like lectin receptor, mannose receptor, mannosyl-fucosyl receptor, scavenger receptor, etc on the macrophage surface may play an important role in active drug targeting. Also, monoclonal antibody, interferon’s, tufstin are other agents which have been broadly utilized for targeting.

Role of calcination on dielectric properties of BaTiO 3 nanoparticles as a gas sensor

Abstract: In this article, the aim is to establish the correlation between the calcination temperature and dielectric properties of BaTiO3 nanoparticles including gas sensing properties. For this purpose, the BaTiO3 nanoparticles have been synthesized using the sol–gel method with low-temperature hydrolysis with varying calcination temperature and time. The structural, morphological, elemental, chemical, dielectric and gas sensing properties have been characterized using XRD, SEM, TEM, EDX, RAMAN Spectroscopy and LCR Meter with Gas Sensing Unit. The cubic phase of BaTiO3 nanoparticles has been confirmed by XRD and the estimated particle size obtained from 20.6 nm to 29.4 nm concerning the change in calcination temperature and time. The morphological study and crystal structure analysis have been performed using SEM and TEM images. Elemental identification has been done by EDX which indicates the presence of Ba, Ti and O in the synthesized compound. The formation of the cubic phase has also been confirmed by Raman analysis with a small shift in peaks toward the higher wave number side. Dielectric properties of synthesized BaTiO3 nanoparticles have been investigated as a function of frequency with temperature variation from 30 to 150 °C. The sensitivity (%) as a function of flow rate and temperature of BaTiO3 nanoparticles have been investigated and observed that BaTiO3 nanoparticles calcinated at 800 °C for 2 h achieved the highest response toward NH3 gas.

Role of bio-metal Fe(III) in anticancer effect of dacarbazine.

Abstract: Physicochemical, Microbial and Pharmacological studies on Fe(III)-Dacarbazine complex have been done in solid and aqueous phase. On the basis of elemental analysis, polarographic studies, amperometric titrations and IR spectral studies the probable formula for the complex has been worked out to be 1:1, Fe(III)-Dacarbazine. The metal ligand interaction has been studied using polarographic method at 25 +/- 1 degrees C and at ionic strength of mu = 1.0 (KCl). Microbial studies on the complex was done against various pathogenic bacteria viz. Pseudomonas mangiferae, Staphylococcus aureus, Salmonella typhi and Vibrio cholarae and fungi i.e. Trichothecium and Chrysosporium sp. using Raper's method. Mouse sarcoma cell line 180 and Balb/C mice were used for the anticancer screening of solid complex in vitro and in vivo respectively. The observed polarographic data, on lingane treatment revealed the formation of single (1:1) (M:L) complex with Fe(III) and dacarbazine ligands. The results of amperometric titrations of Fe(III) with dacarbazine in IM KCl supporting electrolyte pH 7.0 +/- 0.1 supported the above findings the IR data speaks of the complex formation between the metal and the dacarbazine ligand through the two nitrogen one each of primary amide and trizo groups. The results of microbial and pharmacological studies with the M:Drug complex revealed that the anticancer activity of the drug metal complex is nearly doubled as compared to the pure drug. As such Fe(III) dacarbazine complex may be recommended to the therapeutic experts for its possible use as more potent anticancer drug.