Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain

Abstract: Manganese neurotoxicity has been reported to cause a neurodegenerative disease known as parkinsonism. Previous reports have shown that the expression of the KH-type splicing regulatory protein (KHSRP), a nucleic acid-binding protein, and NLRP3 is increased upon Mn exposure. However, the relation between these two during Mn toxicity has not been fully deduced. The mouse neuroblastoma (N2a) and SD rats are treated with LPS and MnCl2 to evaluate the expression of KHSRP and NLRP3. Further, the effect of the NLRP3 inhibitor MCC950 is checked on the expression of NLRP3, KHSRP and pro-inflammatory markers (TNFα, IL-18 and IL-1β) as well as the caspase-1 enzyme. Our results demonstrated an increment in NLRP3 and KHSRP expression post-MnCl2 exposure in N2a cells and rat brain, while on the other hand with LPS exposure only NLRP3 expression levels were elevated and KHSRP was found to be unaffected. An increased expression of KHSRP, NLRP3, pro-inflammatory markers and the caspase-1 enzyme was observed to be inhibited with MCC950 treatment in MnCl2-exposed cells and rats. Manganese exposure induces NLRP3 and KHSRP expression to induce neuroinflammation, suggesting a correlation between both which functions in toxicity-related pathways. Furthermore, MCC950 treatment reversed the role of KHSRP from anti-inflammatory to pro-inflammatory.

In Vitro Neutralization of Naja naja Venom Enzymes by Folk Medicinal Plant Extracts

Abstract: Medicinal plants are known to possess pharmacologically active compounds which have therapeutic properties and number of plants have been evaluated in disease management including venomous bites. P...

Color Histogram- and Smartphone-Based Diabetic Retinopathy Detection System

Abstract: Diabetic Retinopathy (DR) is diabetes-related eye disorder. An initial eye examination is the finest method to avoid DR. In this paper, a low-price DR detection algorithm using mobile phone-and color histogram-based image retrieval technique has been proposed. The mobile phone will take a picture of the patient’s eye with the help of 20D condensing lens, and then implement a color histogram retrieval program to find the similar picture from the collected database. The presented system reduces the professional’s work of DR identification. Our aim is to make an effective, easy, and low-cost eye examination program, which is ideal for underdeveloped regions and make it available to one and all.