Institution
Dr. Hari Singh Gour University
Education•Saugor, Madhya Pradesh, India•
About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.
Topics: Drug delivery, Computer science, Drug carrier, Liposome, Transdermal
Papers published on a yearly basis
Papers
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67 citations
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TL;DR: The results of the present study demonstrated greater effectiveness of dermaly applied diclofenac elastic liposomal formulation in comparison to conventional delivery system, and offers a promising means for the non-invasive treatment of local pain and inflammation by topical application.
Abstract: The aim of the present study was to prepare and characterize novel vesicular carrier elastic liposomes, of most commonly used non-steroidal anti-inflammatory agent diclofenac for its sustained and targeted delivery. Elastic liposomes of diclofenac were prepared and characterized in vitro and in vivo. The effect of different formulation variables like type of surfactant, concentration of surfactant and dose of drug on transdermal flux, amount of drug deposited into the skin, muscle and plasma concentration was investigated. The biological activity of optimized formulation was evaluated using carrageenan induced rat paw edema model and results were compared with commercial hydrogel formulation. The elastic liposomal formulations achieved muscle drug concentration between 2.2 ± 0.14 to 5.3 ± 0.22 μg/g at 12hr. The same dose of commercial hydrogel formulation produced drug levels between 0.41 ± 0.07 to 1.1 ± 0.09 μg/g in the muscle. Plasma concentration study showed regiospecificity of elastic liposomal formulation. The results of in vivo study revealed that incorporation of diclofenac in elastic liposomes increased its biological activity two fold as compared to commercial hydrogel formulation. The results of the present study demonstrated greater effectiveness of dermaly applied diclofenac elastic liposomal formulation in comparison to conventional delivery system. The optimized elastic liposomal formulation offers a promising means for the non-invasive treatment of local pain and inflammation by topical application.
65 citations
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TL;DR: The isolation and spectral data of a new isoflavone, 8-methoxy-5,6,4'-trihydroxyis oflavone 7-O-beta-D-glucopyranoside, from the roots of Asparagus racemosus are reported.
65 citations
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TL;DR: Hydroxyapatite ores were coated with a sugar layer followed by hemoglobin to obtain aquasomes and characterized for size, hemoglobin loading, oxygen-binding characteristics and storage stability, which indicated its potential utility as blood-substitute.
65 citations
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TL;DR: In this article, a system of reusing mycelial fructosyltransferase (FTase) immobilized with two polymers, chitosan and alginate were evaluated for continuous production of fructooligosaccharides (FOS).
64 citations
Authors
Showing all 1166 results
Name | H-index | Papers | Citations |
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Rajat Gupta | 126 | 1240 | 72881 |
Sanjay Jain | 103 | 881 | 46880 |
Ashwani Kumar | 66 | 703 | 18099 |
Narendra K. Jain | 59 | 154 | 9342 |
Suresh P. Vyas | 53 | 182 | 8479 |
Sanyog Jain | 52 | 276 | 8843 |
Prashant Kesharwani | 49 | 232 | 8043 |
Amit K. Goyal | 47 | 157 | 5749 |
Rakesh K. Tekade | 45 | 181 | 5927 |
James P. Stables | 44 | 146 | 6094 |
Vinod Kumar Dixit | 36 | 104 | 3827 |
Umesh Gupta | 34 | 96 | 4541 |
Swarnlata Saraf | 33 | 161 | 4943 |
Govind P. Agrawal | 32 | 59 | 2909 |
Vikas Sharma | 31 | 145 | 3720 |