Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Possible role of epidermal growth factor receptors in the therapy of pancreatic cancer.

Abstract: Pancreatic cancer is considered an 'orphan' cancer because of its relative low incidence. Unfortunately, even with early diagnosis, mortality rates are high and it ranks eighth in the worldwide ranking of deaths due to cancer. The administration of chemotherapeutic agents for the treatment of advanced disease has failed, and current research focuses on the understanding of molecular pathways in order to investigate the role of targeted therapy. It has been known that the development and the progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways of various growth factors, among which the epidermal growth factor receptor (EGFR) plays an important role. Growth factor receptors and their ligands not only regulate normal cell processes, but have also been identified as key regulators of human cancer formation. EGFR has been found to be expressed and altered in pancreatic cancer and clearly plays a significant role in tumor development and progression, including cell proliferation, regulation of apoptotic cell death, angiogenesis, and metastatic spread. The amplitude and kinetics of growth factor signaling are determined mainly by a highly regulated endocytic process that sorts and directs activated receptors to degradation in lysosomes. Therefore, EGFR is a legitimate therapeutic target. The aim of this review is to outline the endocytic escape of EGFRs in cancer with special attention towards recent advances in various approaches adopted for EGFR targeting.

Effect of Penetration Enhancers on Transdermal Delivery of Timolol Maleate

Abstract: In vitro skin permeation of Timolol maleate through human cadaver skin was studied using Franz diffusion cell. The results indicate that the drug penetrates poorly through human cadaver skin. However, skin penetration enhancers such as dimethyl sulfoxide (DMSO), oleic acid (OA) and lauryl chloride (LC) enhanced the permeability of Timolol maleate (TM) through human cadaver skin. The permeation enhancement of drug was maximum by lauryl chloride amongst the three enhancers. Moreover, lauryl chloride increases the permeation of drug through skin with increase in the time of application and concentration on skin. The change in lag time was also observed.

A Study of the Blood Flow Using Newtonian and Non-Newtonian Approach in a Stenosed Artery

Abstract: In the present work, a brief survey has been made on the Newtonian and non-Newtonian approach of blood flow in a step like stenosed artery. A comprehensive theoretical study on the relation between the shear rate and the viscosity of the fluid has been carried out in the case of each non-Newtonian model (e.g. Maxwell fluid model, Casson fluid model, Carreau model, etc.). In this paper, we have considered a backward-facing step for simulation of the blood flow by employing a few of the above-mentioned models. The simulation is performed by using the available CFD package.

Synthesis and Anticonvulsant Activity of Some Novel 3-Aryl Amino/Amino-4-aryl-5-imino-Δ2-1,2,4-thiadiazoline.

Abstract: A series of 3-aryl amino/amino-4-aryl-5-imino-Δ2-1,2,4-thiadiazoline have been synthesized using an appropriate synthetic route and characterized by elemental analyses and spectral data. The anticonvulsant activity of all the synthesized compounds was evaluated against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (ScPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. All the test compounds were administered at doses of 30, 100, and 300 mg/kg body weight and the anticonvulsant activity was noted at 0.5 and 4 h time intervals after the drug administration. Some of the compounds were evaluated for the Phenobarbitone induced hypnosis potentiation test. Among the compounds tested, all except 2h showed protection from MES seizures, whereas only 3b was found to be active in the ScPTZ test.

Analysis on techniques used to recognize and identifying the Human emotions

Abstract: Facial expression is a major area for non-verbal language in day to day life communication. As the statistical analysis shows only 7 percent of the message in communication was covered in verbal communication while 55 percent transmitted by facial expression. Emotional expression has been a research subject of physiology since Darwin’s work on emotional expression in the 19th century. According to Psychological theory the classification of human emotion is classified majorly into six emotions: happiness, fear, anger, surprise, disgust, and sadness. Facial expressions which involve the emotions and the nature of speech play a foremost role in expressing these emotions. Thereafter, researchers developed a system based on Anatomic of face named Facial Action Coding System (FACS) in 1970. Ever since the development of FACS there is a rapid progress of research in the domain of emotion recognition. This work is intended to give a thorough comparative analysis of the various techniques and methods that were applied to recognize and identify human emotions. This analysis results will help to identify the proper and suitable techniques, algorithms and the methodologies for future research directions. In this paper extensive analysis on the various recognition techniques used to identify the complexity in recognizing the facial expression is presented. This work will also help researchers and scholars to ease out the problem in choosing the techniques used in the identification of the facial expression domain.