Dr. Hari Singh Gour University

About: Dr. Hari Singh Gour University is a education organization based out in Saugor, Madhya Pradesh, India. It is known for research contribution in the topics: Drug delivery & Computer science. The organization has 1120 authors who have published 1315 publications receiving 29511 citations. The organization is also known as: Dr Harisingh Gour Vishwavidyalaya & Sagar University.

Antisnake venom properties of medicinal plants

Abstract: Snake envenoming and consequent deaths are of common occurrence in tropical and subtropical regions. Approximately 1,25,000 deaths are witnessed every year and WHO has declared it as a neglected tropical disease in 2009. The immunotheraphy is the only treatment available, but it has side effects like serum sickness, pyrogen reactions moreover the non availability and storage problems has rendered the mankind to look in others sources to treat snake bite deaths. This has led to the investigation of naturally available antidotes or the herbal antidotes. The plants were used by humans from centuries to treat diseases which have become an ancient knowledge which are passed through the generations. Many scientific investigations have been carried out on the grounds of folk knowledge. Some of the plants include Aristolochia indica , Andrographis paniculata , Hemidesmus indicus, Vitis vinifera etc., many metabolites have also been isolated which show promising pharmacological inhibitory effect on the toxic snake venom. Further exploration and characterization of molecules would be able to provide an alternative to the existent Antisnake venom.

Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

Abstract: There is strong evidence that the pro-inflammatory microenvironment during post-partum mammary involution promotes parity-associated breast cancer. Estrogen exposure during mammary involution drives tumor growth through neutrophils' activity. However, how estrogen and neutrophils influence mammary involution are unknown. Combined analysis of transcriptomic, protein, and immunohistochemical data in BALB/c mice showed that estrogen promotes involution by exacerbating inflammation, cell death and adipocytes repopulation. Remarkably, 88% of estrogen-regulated genes in mammary tissue were mediated through neutrophils, which were recruited through estrogen-induced CXCR2 signalling in an autocrine fashion. While neutrophils mediate estrogen-induced inflammation and adipocytes repopulation, estrogen-induced mammary cell death was via lysosome-mediated programmed cell death through upregulation of cathepsin B, Tnf and Bid in a neutrophil-independent manner. Notably, these multifaceted effects of estrogen are mostly mediated by ERα and unique to the phase of mammary involution. These findings are important for the development of intervention strategies for parity-associated breast cancer.

Integrated Yoga Practice in Cardiac Rehabilitation Program: A Randomized Control Trial.

Abstract: Background: Coronary artery disease (CAD) is a detrimental noncommunicable disease, which is increasing due to sedentary lifestyle and urbanization in the young population. It is further elevated w...

Observational aspects of outbursting black hole sources: Evolution of spectro-temporal features and X-ray variability

Abstract: We report on our attempt to understand the outbursting profile of Galactic Black Hole sources, keeping in mind the evolution of temporal and spectral features during the outburst. We present results of evolution of quasi-periodic oscillations, spectral states and possible connection with jet ejections during the outburst phase. Further, we attempt to connect the observed X-ray variabilities (i.e., ‘class’/‘structured’ variabilities, similar to GRS 1915+105) with spectral states of black hole sources. Towards these studies, we consider three black hole sources that have undergone single (XTE J1859+226), a few (IGR J17091-3624) and many (GX 339-4) outbursts since the start of RXTE era. Finally, we model the broadband energy spectra (3–150 keV) of different spectral states using RXTE and NuSTAR observations. Results are discussed in the context of two-component advective flow model, while constraining the mass of the three black hole sources.