Drexel University

About: Drexel University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 26770 authors who have published 51438 publications receiving 1949443 citations. The organization is also known as: Drexel & Drexel Institute.

The Effect of Fading, Channel Inversion, and Threshold Scheduling on Ad Hoc Networks

Abstract: This paper addresses three issues in the field of ad hoc network capacity: the impact of (i) channel fading, (ii) channel inversion power control, and (iii) threshold-based scheduling on capacity. Channel inversion and threshold scheduling may be viewed as simple ways to exploit channel state information (CSI) without requiring cooperation across transmitters. We use the transmission capacity (TC) as our metric, defined as the maximum spatial intensity of successful simultaneous transmissions subject to a constraint on the outage probability (OP). By assuming the nodes are located on the infinite plane according to a Poisson process, we are able to employ tools from stochastic geometry to obtain asymptotically tight bounds on the distribution of the signal-to-interference (SIR) level, yielding in turn tight bounds on the OP (relative to a given SIR threshold) and the TC. We demonstrate that in the absence of CSI, fading can significantly reduce the TC and somewhat surprisingly, channel inversion only makes matters worse. We develop a threshold-based transmission rule where transmitters are active only if the channel to their receiver is acceptably strong, obtain expressions for the optimal threshold, and show that this simple, fully distributed scheme can significantly reduce the effect of fading.

Star cluster ecology IVa: Dissection of an open star cluster---photometry

Abstract: The evolution of star clusters is studied using N-body simulations in which the evolution of single stars and binaries are taken self-consistently into account. Initial conditions are chosen to represent relatively young Galactic open clusters, such as the Pleiades, Praesepe and the Hyades. The calculations include a realistic mass function, primordial binaries and the external potential of the parent Galaxy. Our model clusters are generally significantly flattened in the Galactic tidal field, and dissolve before deep core collapse occurs. The binary fraction decreases initially due to the destruction of soft binaries, but increases later because lower mass single stars escape more easily than the more massive binaries. At late times, the cluster core is quite rich in giants and white dwarfs. There is no evidence for preferential evaporation of old white dwarfs, on the contrary the formed white dwarfs are likely to remain in the cluster. Stars tend to escape from the cluster through the first and second Lagrange points, in the direction of and away from the Galactic center. Mass segregation manifests itself in our models well within an initial relaxation time. As expected, giants and white dwarfs are much more strongly affected by mass segregation than main-sequence stars. Open clusters are dynamically rather inactive. However, the combined effect of stellar mass loss and evaporation of stars from the cluster potential drives its dissolution on a much shorter timescale than if these effects are neglected. The often-used argument that a star cluster is barely older than its relaxation time and therefore cannot be dynamically evolved is clearly in error for the majority of star clusters.

The three-dimensional kinematics and flexibility characteristics of the human ankle and subtalar joints--Part I: Kinematics.

Abstract: The in-vitro, three dimensional kinematic characteristics of the human ankle and subtalar joint were investigated in this study. The main goals of this investigation were: 1) To determine the range of motion of the foot-shank complex and the associated range of motion of the ankle and subtalar joints; 2) To determine the kinematic coupling characteristics of the foot-shank complex, and 3) To identify the relationship between movements at the ankle and subtalar joints and the resulting motion produced between the foot and the shank. The tests were conducted on fifteen fresh amputated lower limbs and consisted of incrementally displacing the foot with respect to the shank while the motion of the articulating bones was measured through a three dimensional position data acquisition system. The kinematic analysis was based on the helical axis parameters describing the incremental displacements between any two of the three articulating bones and on a joint coordinate system used to describe the relative position between the bones. From the results of this investigation it was concluded that: 1) The range of motion of the foot-shank complex in any direction (dorsiflexion/plantarflexion, inversion/eversion and internal rotation/external rotation) is larger than that of either the ankle joint or the subtalar joint.; 2) Large kinematic coupling values are present at the foot-shank complex in inversion/eversion and in internal rotation/external rotation. However, only a slight amount of coupling was observed to occur in dorsiflexion/plantarflexion.; 3) Neither the ankle joint nor the subtalar joint are acting as ideal hinge joints with a fixed axis of rotation.; 4) Motion of the foot-shank complex in any direction is the result of rotations at both the ankle and the subtalar joints. However, the contribution of the ankle joint to dorsiflexion/plantarflexion of the foot-shank complex is larger than that of the subtalar joint and the contribution of the subtalar joint to inversion/eversion is larger than that of the ankle joint.; 5) The ankle and the subtalar joints have an approximately equal contribution to internal rotation/external rotation movements of the foot-shank complex.

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

Abstract: Background: A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of TREM2 may play a more generalized role in neurodegeneration. With this in mind we set out to assess the genetic association of the Alzheimer’s disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders. Results: The study included 609 patients with frontotemporal dementia, 765 with amyotrophic lateral sclerosis, 1493 with Parkinson’s disease, 772 with progressive supranuclear palsy, 448 with ischemic stroke and 1957 controls subjects free of neurodegenerative disease. A significant association was observed for the TREM2 p.R47H substitution in susceptibility to frontotemporal dementia (OR = 5.06; p-value = 0.001) and Parkinson’ sd isease (OR =2 .67; p-value = 0.026), while no evidence of association with risk of amyotrophic lateral sclerosis, progressive supranuclear palsy or ischemic stroke was observed. Conclusions: Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson’s disease in addition to Alzheimer’s disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.