Institution
Drexel University
Education•Philadelphia, Pennsylvania, United States•
About: Drexel University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 26770 authors who have published 51438 publications receiving 1949443 citations. The organization is also known as: Drexel & Drexel Institute.
Papers published on a yearly basis
Papers
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TL;DR: This study proposes several ways in which governments can increase citizen trust and thus encourage the adoption of this new and potentially significant mode of government service, e-Government, and investigates online tax services, already available and used extensively in the West.
Abstract: The growing interest in e-Government raises the question of how governments can increase citizen adoption and usage of their online government services. e-Government becomes especially important given its potential to reduce costs and improve service compared with alternative traditional modes. Citizen trust is proposed to be an important catalyst of e-Government adoption. By investigating online tax services, already available and used extensively in the West, we propose several ways in which governments can increase citizen trust and thus encourage the adoption of this new and potentially significant mode of government service. The proposed e-Government adoption model also takes in account issues of cultural variables, risk, control and technology acceptance.Institution-based trust, such as an independent judicial system with appropriate legal powers, is proposed to be the major tactic to build trust in e-Government. In addition, among new users of online government services, characteristic-based and cognitive-based antecedents should be crucial; general psychological dispositions and knowledge of the process should also engender trust. Among experienced users, on the other hand, it is suggested that the nature of previous interactions with the e-Government system should be the major predictor of trust, and hence of continued use. These propositions are elucidated, as they apply to different cultures and to high-intrusive versus low-intrusive government services. This study has practical implications for the design of mechanisms for the adoption of e-Government.
806 citations
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TL;DR: It is argued that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes, and emerging data indicate that TRPs could be useful in treating disorders other than pain, such as urinary urge incontinence, chronic cough and irritable bowel syndrome.
Abstract: The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also known as VR1) antagonists is based on the concept that endogenous agonists acting on TRPV1 might provide a major contribution to certain pain conditions. Indeed, a number of small-molecule TRPV1 antagonists are already undergoing Phase I/II clinical trials for the indications of chronic inflammatory pain and migraine. Moreover, animal models suggest a therapeutic value for TRPV1 antagonists in the treatment of other types of pain, including pain from cancer. We argue that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes. Moreover, emerging data indicate that TRPV1 antagonists could also be useful in treating disorders other than pain, such as urinary urge incontinence, chronic cough and irritable bowel syndrome. The lack of effective drugs for treating many of these conditions highlights the need for further investigation into the therapeutic potential of TRPV1 antagonists.
805 citations
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TL;DR: This work observed two objective neural correlates of insight: increased activity in the right hemisphere anterior superior temporal gyrus for insight relative to noninsight solutions and a sudden burst of high-frequency neural activity prior to insight solutions.
Abstract: People sometimes solve problems with a unique process called insight, accompanied by an “Aha!” experience. It has long been unclear whether different cognitive and neural processes lead to insight versus noninsight solutions, or if solutions differ only in subsequent subjective feeling. Recent behavioral studies indicate distinct patterns of performance and suggest differential hemispheric involvement for insight and noninsight solutions. Subjects solved verbal problems, and after each correct solution indicated whether they solved with or without insight. We observed two objective neural correlates of insight. Functional magnetic resonance imaging (Experiment 1) revealed increased activity in the right hemisphere anterior superior temporal gyrus for insight relative to noninsight solutions. The same region was active during initial solving efforts. Scalp electroencephalogram recordings (Experiment 2) revealed a sudden burst of high-frequency (gamma-band) neural activity in the same area beginning 0.3 s prior to insight solutions. This right anterior temporal area is associated with making connections across distantly related information during comprehension. Although all problem solving relies on a largely shared cortical network, the sudden flash of insight occurs when solvers engage distinct neural and cognitive processes that allow them to see connections that previously eluded them.
802 citations
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Charité1, Lawrence Berkeley National Laboratory2, Cambridge University Hospitals NHS Foundation Trust3, Wellcome Trust Sanger Institute4, Paul Sabatier University5, University of Manchester6, Newcastle University7, University of Toronto8, Leeds Teaching Hospitals NHS Trust9, Katholieke Universiteit Leuven10, University of Kiel11, University College London12, Drexel University13, University of Cambridge14, Geisinger Medical Center15, St George’s University Hospitals NHS Foundation Trust16, University of Bristol17, Columbia University18, University of Oxford19, Radboud University Nijmegen20, University of Oregon21, Aberystwyth University22, Max Planck Society23
TL;DR: The updated HPO database is described, which provides annotations of 7,278 human hereditary syndromes listed in OMIM, Orphanet and DECIPHER to classes of the HPO, allowing integration of existing datasets and interoperability with multiple biomedical resources.
Abstract: The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes using terms from ontologies for anatomy, cell types, function, embryology, pathology and other domains. This allows interoperability with several resources, especially those containing phenotype information on model organisms such as mouse and zebrafish. Here we describe the updated HPO database, which provides annotations of 7,278 human hereditary syndromes listed in OMIM, Orphanet and DECIPHER to classes of the HPO. Various meta-attributes such as frequency, references and negations are associated with each annotation. Several large-scale projects worldwide utilize the HPO for describing phenotype information in their datasets. We have therefore generated equivalence mappings to other phenotype vocabularies such as LDDB, Orphanet, MedDRA, UMLS and phenoDB, allowing integration of existing datasets and interoperability with multiple biomedical resources. We have created various ways to access the HPO database content using flat files, a MySQL database, and Web-based tools. All data and documentation on the HPO project can be found online.
801 citations
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TL;DR: In this paper, the authors address the issue why some entrepreneurs fail to recognize and exploit opportunities within organizations as well as in the establishment of new ventures, and propose a solution to this problem.
Abstract: Entrepreneurship—the recognition and exploitation of opportunities—is valuable within organizations as well as in the establishment of new ventures. Some studies have addressed the issue why some i...
796 citations
Authors
Showing all 26976 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Peter Libby | 211 | 932 | 182724 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Yury Gogotsi | 171 | 956 | 144520 |
Dennis R. Burton | 164 | 683 | 90959 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
Edward G. Lakatta | 146 | 858 | 88637 |
Gordon T. Richards | 144 | 613 | 110666 |
David Price | 138 | 1687 | 93535 |
Joseph Sodroski | 138 | 542 | 77070 |
Hannu Kurki-Suonio | 138 | 433 | 99607 |
Jun Lu | 135 | 1526 | 99767 |
Stephen F. Badylak | 133 | 530 | 57083 |
Michael E. Thase | 131 | 923 | 75995 |
Edna B. Foa | 129 | 588 | 73034 |