Drexel University

About: Drexel University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 26770 authors who have published 51438 publications receiving 1949443 citations. The organization is also known as: Drexel & Drexel Institute.

The Runaway Growth of Intermediate-Mass Black Holes in Dense Star Clusters

Abstract: We study the growth rate of stars via stellar collisions in dense star clusters, calibrating our analytic calculations with direct N-body simulations of up to 65,536 stars, performed on the GRAPE family of special-purpose computers. We find that star clusters with initial half-mass relaxation times 25 Myr are dominated by stellar collisions, the first collisions occurring at or near the point of core collapse, which is driven by the segregation of the most massive stars to the cluster center, where they end up in hard binaries. The majority of collisions occur with the same star, resulting in the runaway growth of a supermassive object. This object can grow up to ~0.1% of the mass of the entire star cluster and could manifest itself as an intermediate-mass black hole (IMBH). The phase of runaway growth lasts until mass loss by stellar evolution arrests core collapse. Star clusters older than about 5 Myr and with present-day half-mass relaxation times 100 Myr are expected to contain an IMBH.

Multi-platform discovery of haplotype-resolved structural variation in human genomes

Abstract: The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner. We identify 818,054 indel variants (<50 bp) and 27,622 SVs (≥50 bp) per genome. We also discover 156 inversions per genome and 58 of the inversions intersect with the critical regions of recurrent microdeletion and microduplication syndromes. Taken together, our SV callsets represent a three to sevenfold increase in SV detection compared to most standard high-throughput sequencing studies, including those from the 1000 Genomes Project. The methods and the dataset presented serve as a gold standard for the scientific community allowing us to make recommendations for maximizing structural variation sensitivity for future genome sequencing studies.

Control of MXenes' electronic properties through termination and intercalation.

Abstract: MXenes are an emerging family of highly-conductive 2D materials which have demonstrated state-of-the-art performance in electromagnetic interference shielding, chemical sensing, and energy storage. To further improve performance, there is a need to increase MXenes' electronic conductivity. Tailoring the MXene surface chemistry could achieve this goal, as density functional theory predicts that surface terminations strongly influence MXenes' Fermi level density of states and thereby MXenes' electronic conductivity. Here, we directly correlate MXene surface de-functionalization with increased electronic conductivity through in situ vacuum annealing, electrical biasing, and spectroscopic analysis within the transmission electron microscope. Furthermore, we show that intercalation can induce transitions between metallic and semiconductor-like transport (transitions from a positive to negative temperature-dependence of resistance) through inter-flake effects. These findings lay the groundwork for intercalation- and termination-engineered MXenes, which promise improved electronic conductivity and could lead to the realization of semiconducting, magnetic, and topologically insulating MXenes.

A survey on ontology mapping

Abstract: Ontology is increasingly seen as a key factor for enabling interoperability across heterogeneous systems and semantic web applications. Ontology mapping is required for combining distributed and heterogeneous ontologies. Developing such ontology mapping has been a core issue of recent ontology research. This paper presents ontology mapping categories, describes the characteristics of each category, compares these characteristics, and surveys tools, systems, and related work based on each category of ontology mapping. We believe this paper provides readers with a comprehensive understanding of ontology mapping and points to various research topics about the specific roles of ontology mapping.