Institution
Drexel University
Education•Philadelphia, Pennsylvania, United States•
About: Drexel University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 26770 authors who have published 51438 publications receiving 1949443 citations. The organization is also known as: Drexel & Drexel Institute.
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01 Jun 2021TL;DR: A significant association between lymphopenia, thrombocytopenia and elevated levels of CRP, PCT, LDH, D-dimer and COVID-19 severity is found and has the potential to be used as an early biomarker to improve the management of CO VID-19 patients.
Abstract: Objective To evaluate association between biomarkers and outcomes in COVID-19 hospitalised patients. COVID-19 pandemic has been a challenge. Biomarkers have always played an important role in clinical decision making in various infectious diseases. It is crucial to assess the role of biomarkers in evaluating severity of disease and appropriate allocation of resources. Design and setting Systematic review and meta-analysis. English full text observational studies describing the laboratory findings and outcomes of COVID-19 hospitalised patients were identified searching PubMed, Web of Science, Scopus, medRxiv using Medical Subject Headings (MeSH) terms COVID-19 OR coronavirus OR SARS-CoV-2 OR 2019-nCoV from 1 December 2019 to 15 August 2020 following Meta-analyses Of Observational Studies in Epidemiology (MOOSE) guidelines. Participants Studies having biomarkers, including lymphocyte, platelets, D-dimer, lactate dehydrogenase (LDH), C reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, procalcitonin (PCT) and creatine kinase (CK), and describing outcomes were selected with the consensus of three independent reviewers. Main outcome measures Composite poor outcomes include intensive care unit admission, oxygen saturation Results 32 studies with 10 491 confirmed COVID-19 patients were included. We found that lymphopenia (pooled-OR: 3.33 (95% CI: 2.51–4.41); p Conclusion Our study found a significant association between lymphopenia, thrombocytopenia and elevated levels of CRP, PCT, LDH, D-dimer and COVID-19 severity. The results have the potential to be used as an early biomarker to improve the management of COVID-19 patients, by identification of high-risk patients and appropriate allocation of healthcare resources in the pandemic.
357 citations
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TL;DR: The COL9A2 gene, which codes for one of the polypeptide chains of collagen IX that is expressed in the intervertebral disc, was screened for sequence variations in individuals with interverTEbral disc disease and identified a putative disease-causing sequence variation that converted a codon for glutamine to one for tryptophan.
Abstract: Intervertebral disc disease is one of the most common musculoskeletal disorders. A number of environmental and anthropometric risk factors may contribute to it, and recent reports have suggested the importance of genetic factors as well. The COL9A2 gene, which codes for one of the polypeptide chains of collagen IX that is expressed in the intervertebral disc, was screened for sequence variations in individuals with intervertebral disc disease. The analysis identified a putative disease-causing sequence variation that converted a codon for glutamine to one for tryptophan in six out of the 157 individuals but in none of 174 controls. The tryptophan allele cosegregated with the disease phenotype in the four families studied, giving a lod score (logarithm of odds ratio) for linkage of 4.5, and subsequent linkage disequilibrium analysis conditional on linkage gave an additional lod score of 7.1.
357 citations
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TL;DR: This article found that social networks and relational capital enhance levels of illusion of control, which is directly related to the progress of new venture creation and found marginal support for the relationship between social capital and risk propensity.
Abstract: Why does social capital influence the progress of new venture creation for some entrepreneurs more than others? Our investigation suggests that social capital is not enough; that the type of person involved in network relationships matters to new venture creation. We test the effects of the interplay of social capital and cognition on a sample of 269 entrepreneurs. Our results confirm that social networks and relational capital enhance levels of illusion of control, which is directly related to the progress of new venture creation. We find marginal support for the relationship between social capital and risk propensity.
356 citations
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University of Pittsburgh1, University of Cincinnati2, National Institutes of Health3, George Washington University4, University of Alabama at Birmingham5, University of Texas at Austin6, Columbia University7, University of Utah8, University of North Carolina at Chapel Hill9, Case Western Reserve University10, Northwestern University11, University of Texas Health Science Center at Houston12, Brown University13, Ohio State University14, Drexel University15, Wake Forest University16, Oregon Health & Science University17, University of Texas Medical Branch18, University of Texas Southwestern Medical Center19, Wayne State University20
TL;DR: Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension.
Abstract: Background Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension. Methods We conducted a multicenter, randomized, double-blind trial involving nulliparous women who were at low risk for preeclampsia. Women were randomly assigned to begin daily supplementation with 1000 mg of vitamin C and 400 IU of vitamin E or matching placebo between the 9th and 16th weeks of pregnancy. The primary outcome was severe pregnancy-associated hypertension alone or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, medically indicated preterm birth, fetal-growth restriction, or perinatal death. Results A total of ...
356 citations
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TL;DR: This article examined the factors that influence the decision to participate in a work activity or a competing family activity and found that both work and family pressures affected the choice of activity, with the effect of family salience stronger for those who were higher in self-esteem and higher in work salience.
356 citations
Authors
Showing all 26976 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Peter Libby | 211 | 932 | 182724 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Yury Gogotsi | 171 | 956 | 144520 |
Dennis R. Burton | 164 | 683 | 90959 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
Edward G. Lakatta | 146 | 858 | 88637 |
Gordon T. Richards | 144 | 613 | 110666 |
David Price | 138 | 1687 | 93535 |
Joseph Sodroski | 138 | 542 | 77070 |
Hannu Kurki-Suonio | 138 | 433 | 99607 |
Jun Lu | 135 | 1526 | 99767 |
Stephen F. Badylak | 133 | 530 | 57083 |
Michael E. Thase | 131 | 923 | 75995 |
Edna B. Foa | 129 | 588 | 73034 |