Institution
Gdańsk Medical University
Education•Gdańsk, Poland•
About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.
Topics: Population, Cancer, Medicine, Blood pressure, Transplantation
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The authors have summarised the basic recommendations for treating infants with CKD5 in order to support the multidisciplinary teams who endeavour on this difficult task.
Abstract: Background
To provide recommendations for the care of infants with stage 5 chronic kidney disease (CKD5).
84 citations
01 Mar 2018
TL;DR: In this paper, the main features that render melatonin a promising candidate for the management of several dermatoses associated with substantial oxidative damage were synthesized and discussed. But, the full spectrum of functional activities of this free radical-scavenging molecule, which also induces/promotes complex antioxidative and DNA repair systems, includes immunomodulatory, thermoregulatory, and antitumor properties, still awaits to be fully appreciated by dermatologists.
Abstract: Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. Although melatonin is best known to regulate circadian rhythmicity and lower vertebrate skin pigmentation, the full spectrum of functional activities of this free radical-scavenging molecule, which also induces/promotes complex antioxidative and DNA repair systems, includes immunomodulatory, thermoregulatory, and antitumor properties. Because this plethora of functional melatonin properties still awaits to be fully appreciated by dermatologists, the current review synthesizes the main features that render melatonin a promising candidate for the management of several dermatoses associated with substantial oxidative damage. We also review why melatonin promises to be useful in skin cancer prevention, skin photo- and radioprotection, and as an inducer of repair mechanisms that facilitate the recovery of human skin from environmental damage. The fact that human skin and hair follicles not only express functional melatonin receptors but also engage in substantial, extrapineal melatonin synthesis further encourages one to systematically explore how the skin's melatonin system can be therapeutically targeted in future clinical dermatology and enrolled for preventive medicine strategies.
84 citations
••
TL;DR: AgNPs by inducing mixed type of programmed cell death in PANC-1 cells, could provide a new therapeutic strategy to overcome chemoresistance in one of the deadliest human cancer.
Abstract: Pancreatic ductal adenocarcinoma, with the high resistance to chemotherapeutic agents, remains the fourth leading cause of cancer-death in the world. Due to the wide range of biological activity and unique properties, silver nanoparticles (AgNPs) are indicated as agents with potential to overcome barriers involved in chemotherapy failure. Therefore, in our study we decided to assess the ability of AgNPs to kill pancreatic cancer cells, and then to identify the molecular mechanism underlying this effect. Moreover, we evaluated the cytotoxicity of AgNPs against non-tumor cell of the same tissue (hTERT-HPNE cells) for comparison. Our results indicated that AgNPs with size of 2.6 and 18 nm decreased viability, proliferation and caused death of pancreatic cancer cells in a size- and concentration-dependent manner. Ultrastructural analysis identified that cellular uptake of AgNPs resulted in apoptosis, autophagy, necroptosis and mitotic catastrophe. These alterations were associated with increased pro-apoptotic protein Bax and decreased level of anti-apoptotic protein Bcl-2. Moreover, AgNPs significantly elevated the level of tumor suppressor p53 protein as well as necroptosis- and autophagy-related proteins: RIP-1, RIP-3, MLKL and LC3-II, respectively. In addition, we found that PANC-1 cells were more vulnerable to AgNPs-induced cytotoxicity compared to pancreatic non-tumor cells. In conclusion, AgNPs by inducing mixed type of programmed cell death in PANC-1 cells, could provide a new therapeutic strategy to overcome chemoresistance in one of the deadliest human cancer.
84 citations
••
TL;DR: It is demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hSp70Mtb, hsp65MTb, and hsp16MtB are present in lymph node tissues of patients with sarcoidosis (SA).
Abstract: We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70Mtb, hsp65Mtb, and hsp16Mtb, are present in lymph node tissues of patients with sarcoidosis (SA). hsp16Mtb occurs in the early stage of SA, whereas hsp70Mtb occurs in stage II of SA. hsp65Mtb is highly expressed in the capillary vessels in lymph node tissues in patients with SA.
84 citations
••
TL;DR: Different aspects of uprighting impacted second molars are discussed in light of the literature, and the iatrogenic character of lower second molar impaction is emphasized.
Abstract: Impaction of the lower second molar is not a common problem, but it is very challenging for both orthodontist and oral surgeon. Treatment options depend on the degree of tooth inclination, the position of the third molars, and the desired type of movement, which may be surgical and/or orthodontic in nature. A good treatment alternative is surgical uncovering with orthodontically-assisted eruption. A case of successful uprighting using a 0.017 × 0.025–inch titanium molybdenum alloy (TMA) tip-back cantilever is presented. Different aspects of uprighting impacted second molars are discussed in light of the literature. The iatrogenic character of lower second molar impaction is emphasized.
84 citations
Authors
Showing all 4927 results
Name | H-index | Papers | Citations |
---|---|---|---|
Magdi H. Yacoub | 109 | 1267 | 52431 |
Virend K. Somers | 106 | 615 | 54203 |
Felix Mitelman | 95 | 578 | 35416 |
Andrzej Slominski | 91 | 469 | 27900 |
Nils Mandahl | 86 | 427 | 25006 |
Fredrik Mertens | 84 | 406 | 28705 |
Enriqueta Felip | 83 | 622 | 53364 |
Pieter E. Postmus | 81 | 384 | 24039 |
Wilhelm Kriz | 73 | 222 | 19335 |
Godefridus J. Peters | 73 | 523 | 28315 |
Jacek Jassem | 73 | 602 | 35976 |
Piotr Rutkowski | 72 | 563 | 42218 |
Thomas Frodl | 70 | 258 | 16469 |
Eric J. Velazquez | 70 | 396 | 27539 |
Argye E. Hillis | 68 | 398 | 22230 |