Gdańsk Medical University

About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.

Tonic chemoreflex activation contributes to the elevated muscle sympathetic nerve activity in patients with chronic renal failure

Abstract: ObjectiveSympathetic activation may contribute to both cardiovascular morbidity and the progression of chronic kidney disease. The role of the chemoreceptors in determining sympathetic nerve discharge in patients with chronic renal failure (CRF) is unknown. We tested the hypothesis that tonic activa

Skin penetration of terpenes from essential oils and topical vehicles.

Abstract: The purpose of this study was to evaluate the in vitro cutaneous penetration of five terpenes--linalool, linalyl acetate, terpinen-4-ol, citronellol and alpha-pinene--applied in pure essential oils or in dermatological formulations (o/w emulsion, oily solution or hydrogel) containing 0.75 % w/w of the essential oils. Different skin absorption was observed depending on the type of the vehicle and terpenes' log P values. Cutaneous accumulation of terpenes is several times higher when they are applied in pure essential oils than in topical vehicles. Penetration of terpinen-4-ol to the skin was better from an oily solution (approximately 90 microg/cm (2)) than from an emulsion (60 microg/cm (2)). No penetration of linalyl acetate from topical vehicles into viable skin was observed, but also for this terpene penetration to the upper layers of the stratum corneum was 2-times higher when an oily solution was used. In contrast, the cutaneous absorption of linalool was the same from both vehicles (50-60 microg/cm (2)). The skin penetration of alpha-pinene was not traceable when it was applied in an oily solution. Only a small amount (approximately 5 microg/cm (2)) of this terpene was determined in viable skin after application as a hydrogel. Citronellol applied in a hydrogel penetrated into all skin layers in a total amount of 25 microg/cm (2), while no penetration into viable skin layers after application of an oily solution was noted. Only citronellol permeated into the acceptor medium.

Activation of RAS family members confers resistance to ROS1 targeting drugs.

Abstract: // Marilisa Cargnelutti 1 , Simona Corso 1,2 , Margherita Pergolizzi 1 , Laurence Mevellec 3 , Dara L. Aisner 4 , Rafal Dziadziuszko 5 , Marileila Varella-Garcia 4,6 , Paolo M. Comoglio 1,2 , Robert C. Doebele 6 , Jorge Vialard 7 and Silvia Giordano 1,2 1 Candiolo Cancer Institute - FPO, IRCCS, Torino, Italy 2 Department of Oncology, University of Torino, Italy 3 Janssen Research & Development, Janssen-Cilag, Val-de-Reuil, France 4 Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA 5 Medical University of Gdansk, Poland 6 Department of Medicine, Division of Medical Oncology University of Colorado School of Medicine, Aurora, CO, USA 7 Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium Correspondence: Simona Corso, email: // Silvia Giordano, email: // Keywords : drug resistance, RAS, ROS1, lung cancer, targeted therapy Received : November 11, 2014 Accepted : December 29, 2014 Published : December 31, 2014 Abstract The ROS1 tyrosine kinase is activated in lung cancer as a consequence of chromosomal rearrangement. Although high response rates and disease control have been observed in lung cancer patients bearing rearranged ROS1 tumors (ROS1+) treated with the kinase inhibitor crizotinib, many of these patients eventually relapse. To identify mechanisms of resistance to ROS1 inhibitors we generated resistant cells from HCC78 lung cancer cells bearing the SLC34A2-ROS1 rearrangement. We found that activation of the RAS pathway in the HCC78 cell model, due to either KRAS/NRAS mutations or to KRAS amplification, rendered the cells resistant to ROS1 inhibition. These cells were cross-resistant to different ROS1 inhibitors, but sensitive to inhibitors of the RAS signaling pathway. Interestingly, we identified focal KRAS amplification in a biopsy of a tumor from a patient that had become resistant to crizotinib treatment. Altogether our data suggest that the activation of members of the RAS family can confer resistance to ROS1 inhibitors. This has important clinical implications as: (i) RAS genetic alterations in ROS1+ primary tumors are likely negative predictors of efficacy for targeted drugs and (ii) this kind of resistance is unlikely to be overcome by the use of more specific or more potent ROS1 targeting drugs.

Early detection of chronic kidney disease: results of the PolNef study

Abstract: Background: Continuous increase in the number of patients with end-stage renal disease demands early detection of chronic kidney disease (CKD) The aim of the present study was to d