Showing papers by "Hampshire College published in 2015"

Estimating the reproducibility of psychological science

Abstract: Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

General Program Synthesis Benchmark Suite

Abstract: Recent interest in the development and use of non-trivial benchmark problems for genetic programming research has highlighted the scarcity of general program synthesis (also called "traditional programming") benchmark problems. We present a suite of 29 general program synthesis benchmark problems systematically selected from sources of introductory computer science programming problems. This suite is suitable for experiments with any program synthesis system driven by input/output examples. We present results from illustrative experiments using our reference implementation of the problems in the PushGP genetic programming system. The results show that the problems in the suite vary in difficulty and can be useful for assessing the capabilities of a program synthesis system.

Solving Uncompromising Problems With Lexicase Selection

Abstract: We describe a broad class of problems, called “uncompromising problems,” which are characterized by the requirement that solutions must perform optimally on each of many test cases. Many of the problems that have long motivated genetic programming research, including the automation of many traditional programming tasks, are uncompromising. We describe and analyze the recently proposed “lexicase” parent selection algorithm and show that it can facilitate the solution of uncompromising problems by genetic programming. Unlike most traditional parent selection techniques, lexicase selection does not base selection on a fitness value that is aggregated over all test cases; rather, it considers test cases one at a time in random order. We present results comparing lexicase selection to more traditional parent selection methods, including standard tournament selection and implicit fitness sharing, on four uncompromising problems: 1) finding terms in finite algebras; 2) designing digital multipliers; 3) counting words in files; and 4) performing symbolic regression of the factorial function. We provide evidence that lexicase selection maintains higher levels of population diversity than other selection methods, which may partially explain its utility as a parent selection algorithm in the context of uncompromising problems.

The emergence of sex differences in personality traits in early adolescence: A cross-sectional, cross-cultural study.

Abstract: Although large international studies have found consistent patterns of sex differences in personality traits among adults (i.e., women scoring higher on most facets), less is known about cross-cultural sex differences in adolescent personality and the role of culture and age in shaping them. The present study examines the NEO Personality Inventory-3 (McCrae, Costa, & Martin, 2005) informant ratings of adolescents from 23 cultures (N = 4,850), and investigates culture and age as sources of variability in sex differences of adolescents' personality. The effect for Neuroticism (with females scoring higher than males) begins to take on its adult form around age 14. Girls score higher on Openness to Experience and Conscientiousness at all ages between 12 and 17 years. A more complex pattern emerges for Extraversion and Agreeableness, although by age 17, sex differences for these traits are highly similar to those observed in adulthood. Cross-sectional data suggest that (a) with advancing age, sex differences found in adolescents increasingly converge toward adult patterns with respect to both direction and magnitude; (b) girls display sex-typed personality traits at an earlier age than boys; and (c) the emergence of sex differences was similar across cultures. Practical implications of the present findings are discussed. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

Superdense teleportation using hyperentangled photons.

Abstract: Transmitting quantum information between two remote parties is a requirement for many quantum applications; however, direct transmission of states is often impossible because of noise and loss in the communication channel. Entanglement-enhanced state communication can be used to avoid this issue, but current techniques require extensive experimental resources to transmit large quantum states deterministically. To reduce these resource requirements, we use photon pairs hyperentangled in polarization and orbital angular momentum to implement superdense teleportation, which can communicate a specific class of single-photon ququarts. We achieve an average fidelity of 87.0(1)%, almost twice the classical limit of 44% with reduced experimental resources than traditional techniques. We conclude by discussing the information content of this constrained set of states and demonstrate that this set has an exponentially larger state space volume than the lower-dimensional general states with the same number of state parameters.

Comparison of Semantic-aware Selection Methods in Genetic Programming

Abstract: This study investigates the performance of several semantic- aware selection methods for genetic programming (GP) In particular, we consider methods that do not rely on complete GP semantics (ie, a tuple of outputs produced by a program for fitness cases (tests)), but on binary outcome vectors that only state whether a given test has been passed by a program or not This allows us to relate to test-based problems commonly considered in the domain of coevolutionary algorithms and, in prospect, to address a wider range of practical problems, in particular the problems where desired program output is unknown (eg, evolving GP controllers) The selection methods considered in the paper include implicit fitness sharing (ifs), discovery of derived objectives (doc), lexicase selection (lex), as well as a hybrid of the latter two These techniques, together with a few variants, are experimentally compared to each other and to conventional GP on a battery of discrete benchmark problems The outcomes indicate superior performance of lex and ifs, with some variants of doc showing certain potential

The effects of rock climbing on cliff‐face vegetation

Abstract: Question What are the effects of rock climbing on diversity, abundance and composition on cliff-face vegetation along environmental and use gradients typical of modern climbing? Location New River Gorge National River, WV, US. Methods We compared species richness, abundance and composition of vascular plants, bryophytes and lichens on 79 pre-established rock climbs and 32 unclimbed ‘control’ sites across potential climb-use intensity and cliff structure using linear models, residual analysis and NMDS ordination. Results Differences in species richness and abundance associated with potential climb-use intensity and cliff structure were variable across taxonomic groups. Linear models indicated that cliff angle was the strongest explanatory variable of species richness and abundance for all three taxonomic groups. Once the effects of biophysical variables were modelled, analysis of the residuals indicated that potential climbing-use intensity had a small but negative effect on species richness and abundance of vascular plants (range 3–6%), no effect on bryophytes (0%) and a substantial effect on lichens (range 10–12%). Similarly, NMDS ordination indicated that cliff angle, canopy height and aspect were the primary drivers of species composition. We observed no change in community composition due to climbing. Conclusions Other studies have observed significant impacts of climbing on vegetation at the base of cliffs. Here, we observe that potential climbing-use intensity has some impact on species richness and abundance of vascular plants and more significant impacts on lichens, however cliff angle is a fundamental control on cliff vegetation. Because of the challenge in sampling steep and overhanging cliffs, we recommend that climbers be directly involved in the assessment, monitoring and management of cliff resources in order to ensure that the full range of biophysical conditions of cliff ecosystems are considered.

Genetic Programming with Epigenetic Local Search

Abstract: We focus on improving genetic programming through local search of the space of program structures using an inheritable epigenetic layer that specifies active and inactive genes. We explore several genetic programming implementations that represent the different properties that epigenetics can provide, such as passive structure, phenotypic plasticity, and inheritable gene regulation. We apply these implementations to several symbolic regression and program synthesis problems. For the symbolic regression problems, the results indicate that epigenetic local search consistently improves genetic programming by producing smaller solution programs with better fitness. Furthermore, we find that incorporating epigenetic modification as a mutation step in program synthesis problems can improve the ability of genetic programming to find exact solutions. By analyzing population homology we show that the epigenetic implementations maintain diversity in silenced portions of programs which may provide protection from premature convergence.

Assessment of Pain and Activity Using an Electronic Pain Diary and Actigraphy Device in a Randomized, Placebo‐Controlled Crossover Trial of Celecoxib in Osteoarthritis of the Knee

Abstract: Objective The primary goal was to determine whether a composite measure of pain and activity is a more responsive assessment of analgesic effect than pain alone or activity alone in patients with osteoarthritis (OA) of the knee. Design We conducted a randomized, double-blind, placebo-controlled, 2-period, crossover study of celecoxib vs. placebo in subjects with chronic pain due to knee OA. Patients with knee OA and baseline pain intensity score ≥4 on a 0–10 numerical rating scale (NRS) before each period were randomized. Pain endpoints included in-clinic pain score (24-hour and 1-week recall), daily paper diary pain score, current pain on an electronic pain diary (each on NRS), and WOMAC pain subscale. Activity measures included WOMAC function subscale and actigraphy using a device. Three composite pain–activity measures were prespecified. Results Sixty-three patients were randomized and 47 completed the study. The WOMAC pain subscale was the most responsive of all five pain measures. Pain–activity composites resulted in a statistically significant difference between celecoxib and placebo but were not more responsive than pain measures alone. However, a composite responder defined as having 20% improvement in pain or 10% improvement in activity yielded much larger differences between celecoxib and placebo than with pain scores alone. Actigraphy was more responsive than the WOMAC function scale, possibly due to lower placebo responsiveness. Conclusion We have identified composite pain–activity measures that are similarly or more responsive than pain-alone measures in patients with OA. Further research is warranted to determine the optimal method for computing these composites.

Fruit secondary compounds mediate the retention time of seeds in the guts of Neotropical fruit bats.

Abstract: Plants often recruit frugivorous animals to transport their seeds; however, gut passage can have varying effects on plant fitness depending on the physical and chemical treatment of the seed, the distance seeds are transported, and the specific site of deposition. One way in which plants can mediate the effects of gut passage on fitness is by producing fruit secondary compounds that influence gut-retention time (GRT). Using frugivorous bats (Carollia perspicillata: Phyllostomidae) and Neotropical plants in the genus Piper, we compared GRT of seeds among five plant species (Piper colonense, Piper peltatum, Piper reticulatum, Piper sancti-felicis, and Piper silvivagum) and investigated the role of fruit amides (piperine, piplartine and whole fruit amide extracts from P. reticulatum) in mediating GRT. Our results showed interspecific differences in GRT; P. reticulatum seeds passed most slowly, while P. silvivagum and P. colonense seeds passed most rapidly. Piplartine and P. reticulatum amide extracts decreased GRT, while piperine had no effect. In addition, we examined the effects of GRT on seed germination success and speed in laboratory conditions. For germination success, the effects were species specific; germination success increased with GRT for P. peltatum but not for other species. GRT did not influence germination speed in any of the species examined. Plant secondary compounds have primarily been studied in the context of their defensive role against herbivores and pathogens, but may also play a key role in mediating seed dispersal interactions.

Making sense of Islamic creationism in Europe.

Abstract: Islamic creationism has been noted as a serious concern in Europe. There have been reports of boycotts of university evolution lectures and, in one extreme case, even a threat of violence. While religious objections are indeed at play in some cases, our understanding of the rise of Islamic creationism should also take into account socioeconomic disparities and its impact on education for Muslim minorities in Europe. Furthermore, the broader narrative of rejection of evolution in Europe, for some Muslims, may be bound up in reactions to the secular culture and in the formation of their own minority religious identity. On the other hand, the stories of Muslim rejection of evolution in media end up reinforcing the stereotype of Muslims as "outsiders" and a threat to the European education system. A nuanced understanding of this dynamic may benefit those who support both the propagation of good science and favor cultural pluralism.

Urinary arsenic speciation profile in ethnic group of the Atacama desert (Chile) exposed to variable arsenic levels in drinking water

Abstract: Ethnic groups from the Atacama Desert (known as Atacamenos) have been exposed to natural arsenic pollution for over 5000 years. This work presents an integral study that characterizes arsenic species in water used for human consumption. It also describes the metabolism and arsenic elimination through urine in a chronically exposed population in northern Chile. In this region, water contained total arsenic concentrations up to 1250 μg L−1, which was almost exclusively As(V). It is also important that this water was ingested directly from natural water sources without any treatment. The ingested arsenic was extensively methylated. In urine 93% of the arsenic was found as methylated arsenic species, such as monomethylarsonic acid [MMA(V)] and dimethylarsinic acid [DMA(V)]. The original ingested inorganic species [As(V)], represent less than 1% of the total urinary arsenic. Methylation activity among individuals can be assessed by measuring primary [inorganic As/methylated As] and secondary methylation [MMA/D...

Ecosystem Structure Emerges as a Strong Determinant of Food-Chain Length in Linked Stream–Riparian Ecosystems

Abstract: Environmental determinants of fluvial food-chain length (FCL) remain unresolved, with predominant hypotheses pointing to productivity, disturbance, and/or ecosystem size. However, drainage configuration (for example, drainage density, and stream length)—in spite of recent advances demonstrating the significance of catchment structure to habitat and biodiversity of fluvial systems—has yet to be explored in relation to FCL. In this study, we quantified the relative influences of ecosystem size and structure on FCL for linked stream‐riparian food webs. At 19 stream reaches distributed within three mountain catchments of northern Idaho, USA, we sampled aquatic and riparian consumers and determined FCL using the naturally abundant stable isotopes 13 Ca nd 15 N. Food-chain length was approach. Model selection was followed by exploratory linear regression of FCL with purported mechanistic factors (that is, resource availability and disturbance regime). FCL ranged from 2.6 to 4.4 across study reaches and was best explained by catchment structure such as number of tributary junctions and distance to nearest downstream confluence. Regression analyses suggested that disturbance regime may mechanistically link number of tributary junctions and FCL, as well as drainage area and FCL. Our results introduce novel evidence that ecosystem structure may integrate the effects of several mechanistic factors and thus be an important predictor of food-web structure.

Analyzing a Decade of Human-Competitive (“HUMIE”) Winners: What Can We Learn?

Abstract: Techniques in evolutionary computation (EC) have improved significantly over the years, leading to a substantial increase in the complexity of problems that can be solved by EC-based approaches. The HUMIES awards at the Genetic and Evolutionary Computation Conference are designed to recognize work that has not just solved some problem via techniques from evolutionary computation, but has produced a solution that is demonstrably human-competitive. In this chapter, we take a look across the winners of the past 10 years of the HUMIES awards, and analyze them to determine whether there are specific approaches that consistently show up in the HUMIE winners. We believe that this analysis may lead to interesting insights regarding prospects and strategies for producing further human competitive results.

Colombian forensic genetics as a form of public science: The role of race, nation and common sense in the stabilization of DNA populations

Abstract: This article examines the role that vernacular notions of racialized-regional difference play in the constitution and stabilization of DNA populations in Colombian forensic science, in what we frame as a process of public science. In public science, the imaginations of the scientific world and common-sense public knowledge are integral to the production and circulation of science itself. We explore the origins and circulation of a scientific object – ‘La Tabla’, published in Paredes et al. and used in genetic forensic identification procedures – among genetic research institutes, forensic genetics laboratories and courtrooms in Bogota. We unveil the double life of this central object of forensic genetics. On the one hand, La Tabla enjoys an indisputable public place in the processing of forensic genetic evidence in Colombia (paternity cases, identification of bodies, etc.). On the other hand, the relations it establishes between ‘race’, geography and genetics are questioned among population geneticists in Colombia. Although forensic technicians are aware of the disputes among population geneticists, they use and endorse the relations established between genetics, ‘race’ and geography because these fit with common-sense notions of visible bodily difference and the regionalization of race in the Colombian nation.

Inheritable Epigenetics in Genetic Programming

Abstract: Classical genetic programming solves problems by applying the Darwinian concepts of selection, survival and reproduction to a population of computer programs. Here we extend the biological analogy to incorporate epigenetic regulation through both learning and evolution. We begin the chapter with a discussion of Darwinian, Lamarckian, and Baldwinian approaches to evolutionary computation and describe how recent findings in biology differ conceptually from the computational strategies that have been proposed. Using inheritable Lamarckian mechanisms as inspiration, we propose a system that allows for updating of individuals in the population during their lifetime while simultaneously preserving both genotypic and phenotypic traits during reproduction. The implementation is made simple through the use of syntax-free, developmental, linear genetic programming. The representation allows for arbitrarily-ordered genomes to be syntactically valid programs, thereby creating a genetic programming approach upon which quasi-uniform epigenetic updating and inheritance can easily be applied. Generational updates are made using an epigenetic hill climber (EHC), and the epigenetic properties of genes are inherited during crossover and mutation. The addition of epigenetics results in faster convergence, less bloat, and an improved ability to find exact solutions on a number of symbolic regression problems.

NeuroPG: open source software for optical pattern generation and data acquisition

Abstract: Patterned illumination using a digital micromirror device (DMD) is a powerful tool for optogenetics Compared to a scanning laser, DMDs are inexpensive and can easily create complex illumination patterns Combining these complex spatiotemporal illumination patterns with optogenetics allows DMD-equipped microscopes to probe neural circuits by selectively manipulating the activity of many individual cells or many subcellular regions at the same time To use DMDs to study neural activity, scientists must develop specialized software to coordinate optical stimulation patterns with the acquisition of electrophysiological and fluorescence data To meet this growing need we have developed an open source optical pattern generation software for neuroscience-NeuroPG-that combines, DMD control, sample visualization, and data acquisition in one application Built on a MATLAB platform, NeuroPG can also process, analyze, and visualize data The software is designed specifically for the Mightex Polygon400; however, as an open source package, NeuroPG can be modified to incorporate any data acquisition, imaging, or illumination equipment that is compatible with MATLAB's Data Acquisition and Image Acquisition toolboxes

Visual search and the N2pc in children

Abstract: While there is growing understanding of visual selective attention in children, some aspects such as selection in the presence of distractors are not well understood. Adult studies suggest that when presented with a visual search task, an enhanced negativity is seen beginning around 200 ms (the N2pc) that reflects selection of a target item among distractors. However, it is not known if similar selective attention-related activity is seen in children during visual search. This study was designed to investigate the presence of the N2pc in children. Nineteen children (ages 9–12 years) and 21 adults (ages 18–22 years) completed a visual search task in which they were asked to attend to a fixation surrounded by both a target and a distractor stimulus. Three types of displays were analyzed at parietal electrodes P7 and P8; lateral target/lateral distractor, lateral target/midline distractor, and midline target/lateral distractor. Both adults and children showed a significant increased negativity contralateral compared to ipsilateral to the target (reflected in the N2pc) in both displays with a lateral target while no such effect was seen in displays with a midline target. This suggests that children also utilized additional resources to select a target item when distractors are present. These findings demonstrate that the N2pc can be used as a marker of attentional object selection in children.

Migrant bodies and the materialization of belonging in Sweden

Abstract: Immigration and transnational adoption are both manifestations of the pervasive dislocations that characterize the contemporary era. Each illuminates as well the double movement of assimilation and internal exclusion through which racisms that are a heritage of colonialism are expanded and reactivated in the metropolitan centers of western Europe and North America. In this process, race is spatialized, different forms of migrant bodies are produced, and familiar logics of belonging that link person to place are transformed. The differential politics of adoption and immigration in late twentieth-century Sweden shed light on this process of racialization and the affective economies through which it is realized, as that nation pursues a multicultural project in which ‘Swedishness’ becomes ‘the measure of everything.’

Biodegradation of tributyltin (TBT) by extremophile bacteria from Atacama Desert and speciation of tin by-products.

Abstract: Biodegradation of tributyltin (TBT) by four tin resistant Gram negative bacteria isolated from extremely contaminated river sediments in the Atacama Desert in Chile was studied. Moraxella osloensis showed the greatest resistance and degradation capability of TBT, producing less toxic by-products, such as dibutyltin (DBT) and inorganic tin. In 7 days, approximately 80 % of TBT degradation was achieved, generating close to 20 % of DBT as degradation product. The degradation rate constant (k) was 0.022 [day−1] and TBT half-life (t1/2) in culture was 4.3 days. Debutylation is stated a probable mechanism of TBT degradation.

Comparison of depth of necrosis using cryotherapy by gas and number of freeze cycles.

Abstract: Objective This study aimed to establish the noninferiority of a single-freeze application with CO2 or N2O compared with the standard double freeze with N2O for cryotherapy treatment. Materials and methods Sixty women undergoing hysterectomy for reasons other than cervical cancer or precancer were randomized to 1 of 3 techniques as follows: (1) double freeze with N2O, (2) single freeze with N2O, or (3) single freeze with CO2. The cervix was separated and cut into anterior and posterior segments, and the deepest area of necrosis was recorded. Comparisons were made using regression analysis. The margin of noninferiority was defined as 0.8 mm. Results On the anterior lip, a single freeze with N2O was noninferior to a double freeze of the same gas, but on the posterior lip, the single freeze was not. The single freeze of CO2 did not provide sufficient depth of necrosis in either lip to infer noninferiority versus the double freeze with N2O. Conclusions A single freeze with N2O is noninferior to a double-freeze technique in the anterior but not the posterior lip. However, the result for posterior lips was close to reaching statistical significance. In addition, CO2 had approximately 1 mm shallower depth of necrosis compared with N2O techniques; however, the clinical implications are unknown. Given the extensive use of CO2 globally, further clinical evaluation is needed.

Disaster metrics: evaluation of de Boer's Disaster Severity Scale (DSS) applied to earthquakes

Abstract: Introduction Quantitative measurement of the medical severity following multiple-casualty events (MCEs) is an important goal in disaster medicine. In 1990, de Boer proposed a 13-point, 7-parameter scale called the Disaster Severity Scale (DSS). Parameters include cause, duration, radius, number of casualties, nature of injuries, rescue time, and effect on surrounding community. Hypothesis This study aimed to examine the reliability and dimensionality (number of salient themes) of de Boer's DSS scale through its application to 144 discrete earthquake events. METHODS: A search for earthquake events was conducted via National Oceanic and Atmospheric Administration (NOAA) and US Geological Survey (USGS) databases. Two experts in the field of disaster medicine independently reviewed and assigned scores for parameters that had no data readily available (nature of injuries, rescue time, and effect on surrounding community), and differences were reconciled via consensus. Principle Component Analysis was performed using SPSS Statistics for Windows Version 22.0 (IBM Corp; Armonk, New York USA) to evaluate the reliability and dimensionality of the DSS. RESULTS: A total of 144 individual earthquakes from 2003 through 2013 were identified and scored. Of 13 points possible, the mean score was 6.04, the mode = 5, minimum = 4, maximum = 11, and standard deviation = 2.23. Three parameters in the DSS had zero variance (ie, the parameter received the same score in all 144 earthquakes). Because of the zero contribution to variance, these three parameters (cause, duration, and radius) were removed to run the statistical analysis. Cronbach's alpha score, a coefficient of internal consistency, for the remaining four parameters was found to be robust at 0.89. Principle Component Analysis showed uni-dimensional characteristics with only one component having an eigenvalue greater than one at 3.17. The 4-parameter DSS, however, suffered from restriction of scoring range on both parameter and scale levels. CONCLUSION: Jan de Boer's DSS in its 7-parameter format fails to hold statistically in a dataset of 144 earthquakes subjected to analysis. A modified 4-parameter scale was found to quantitatively assess medical severity more directly, but remains flawed due to range restriction on both individual parameter and scale levels. Further research is needed in the field of disaster metrics to develop a scale that is reliable in its complete set of parameters, capable of better fine discrimination, and uni-dimensional in measurement of the medical severity of MCEs. Bayram JD , Zuabi S , McCord CM , Sherak RAG , Hsu EB , Kelen GD. Disaster metrics: evaluation of de Boer's Disaster Severity Scale (DSS) applied to earthquakes. Prehosp Disaster Med. 2015;30(1):1-6. Language: en

Superdense teleportation and quantum key distribution for space applications

Abstract: The transfer of quantum information over long distances has long been a goal of quantum information science and is required for many important quantum communication and computing protocols. When these channels are lossy and noisy, it is often impossible to directly transmit quantum states between two distant parties. We use a new technique called superdense teleportation to communicate quantum information deterministically with greatly reduced resources, simplified measurements, and decreased classical communication cost. These advantages make this technique ideal for communicating quantum information for space applications. We are currently implementing an superdense teleportation lab demonstration, using photons hyperentangled in polarization and temporal mode to communicate a special set of two-qubit, single-photon states between two remote parties. A slight modification of the system readily allows it to be used to implement quantum cryptography as well. We investigate the possibility of implementation from an Earth’s orbit to ground. We will discuss our current experimental progress and the design challenges facing a practical demonstration of satellite-to-Earth SDT.

Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos.

Abstract: It is well known that gene regulation is a tightly controlled process in early organismal development. However, the roles of key processes involved in this regulation, such as transcription and translation, are less well understood, and mathematical modeling approaches in this field are still in their infancy. In recent studies, biologists have taken precise measurements of protein and mRNA abundance to determine the relative contributions of key factors involved in regulating protein levels in mammalian cells. We now approach this question from a mathematical modeling perspective. In this study, we use a simple dynamic mathematical model that incorporates terms representing transcription, translation, mRNA and protein decay, and diffusion in an early Drosophila embryo. We perform global sensitivity analyses on this model using various different initial conditions and spatial and temporal outputs. Our results indicate that transcription and translation are often the key parameters to determine protein abundance. This observation is in close agreement with the experimental results from mammalian cells for various initial conditions at particular time points, suggesting that a simple dynamic model can capture the qualitative behavior of a gene. Additionally, we find that parameter sensitivites are temporally dynamic, illustrating the importance of conducting a thorough global sensitivity analysis across multiple time points when analyzing mathematical models of gene regulation.

Peritoneal Pigmentation in Purebred and Hybrid River Herring

Abstract: River herring (Alewives Alosa pseudoharengus and Blueback Herring A. aestivalis [bluebacks]) are congeneric, anadromous clupeid fishes that hybridize in areas of sympatry. Peritoneal pigmentation is the most diagnostic characteristic used to distinguish the species, but pigmentation has not been examined in hybrids. We developed a molecular-based assay to distinguish purebred river herring species from F1 hybrids and compared the peritoneal pigmentation among captive-raised purebred and hybrid individuals. Both wild-caught Alewife and blueback females tank-spawned with conspecific and congeneric males, but Alewives required exogenous hormone administration. Larvae of both species and hybrids were raised for ∼290 d posthatch, and peritoneal pigmentation was quantified. A nuclear gene (rag2) restriction fragment length polymorphism assay was used for species and hybrid identification. The peritoneal pigmentation was significantly darker in hatchery-spawned bluebacks than in Alewives, and hybrids exh...

Disputes, Social Construction and Transformation

Abstract: The social construction of disputes refers to the process by which injuries are perceived and asserted as claims before a third party. Disputes are not objective events, but are social constructs. Transformation of disputes refers to change in their form or content as they are rephrased into legal language and as other participants become involved in the disputing process. Key contributions of the dispute transformation perspective include psychological insight into the perception and assertion of grievances; sociological analysis of the distribution of grievances, claims, and court cases for different types of injuries or problems; empirical work on the role of lawyers in transforming disputes; anthropological study of language and conflict; and political science research on how courts and other institutions shape the construction of disputes. Understanding how disputes emerge and are transformed links a microanalysis of dispute resolution with a macroview of Law, political order and change.