Institution
John Radcliffe Hospital
Healthcare•Oxford, Oxfordshire, United Kingdom•
About: John Radcliffe Hospital is a healthcare organization based out in Oxford, Oxfordshire, United Kingdom. It is known for research contribution in the topics: Population & Antigen. The organization has 14491 authors who have published 23670 publications receiving 1459015 citations.
Topics: Population, Antigen, Transplantation, Gene, Immune system
Papers published on a yearly basis
Papers
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TL;DR: It is proposed that a critical determinant of life-time disease risk is the ability to develop clinical immunity early in life during a period when other protective mechanisms may operate, and measures which reduce parasite transmission, and thus immunity, may lead to a change in both the clinical spectrum of severe disease and the overall burden of severe malaria morbidity.
705 citations
704 citations
TL;DR: Using PCR in situ hybridization (PCR-ISH) it is shown that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells.
Abstract: Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus in KS tumour tissue. Using PCR in situ hybridization (PCR-ISH) we show that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells. These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions.
702 citations
TL;DR: It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.
696 citations
TL;DR: Enumeration of extracellular vesicles has clinical potential as a biomarker for disease and currently employed techniques detect concentrations ranging from 104 to 1012 vesicle mL–1.
695 citations
Authors
Showing all 14542 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas G. Altman | 253 | 1001 | 680344 |
| Salim Yusuf | 231 | 1439 | 252912 |
| David J. Hunter | 213 | 1836 | 207050 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Richard Peto | 183 | 683 | 231434 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Adrian L. Harris | 170 | 1084 | 120365 |
| Rory Collins | 162 | 489 | 193407 |
| Nicholas J. White | 161 | 1352 | 104539 |
| David W. Johnson | 160 | 2714 | 140778 |
| David Cella | 156 | 1258 | 106402 |
| Edmund T. Rolls | 153 | 612 | 77928 |
| Martin A. Nowak | 148 | 591 | 94394 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |