Sapienza University of Rome

About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.

Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer.

Abstract: Breast cancer is the most common type of malignancy diagnosed in women. In the metastatic setting this disease is still uncurable. Taxanes represent an important class of antitumor agents which have proven to be fundamental in the treatment of advanced and early-stage breast cancer, but the clinical advances of taxanes have been limited by their highly hydrophobic molecular status. To overcome this poor water solubility, lipid-based solvents have been used as a vehicle, and new systemic formulations have been developed, mostly for paclitaxel, which are Cremophor-free and increase the circulation time of the drug. ABI-007 is a novel, albumin-bound, 130-nm particle formulation of paclitaxel, free from any kind of solvent. It has been demonstrated to be superior to an equitoxic dose of standard paclitaxel with a significantly lower incidence of toxicities in a large, international, randomized phase III trial. The availability of new drugs, such as Abraxane, in association with other traditional and non-traditional drugs (new antineoplastic agents and targeted molecules), will give the oncologist many different effective treatment options for patients in this setting.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Abstract: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.

Personality and Politics: Values, Traits, and Political Choice

Abstract: Voters' political choices have presumably come to depend more on their personal preferences and less on their social characteristics in Western democracies. We examine two aspects of personality that may influence political choice, traits and personal values, using the Five Factor Model of personality traits and the Schwartz (1992) theory of basic personal values. Data from 3044 voters for the major coalitions in the Italian national election of 2001 showed that supporters of the two coalitions differed in traits and values, largely as hypothesized. Center-left voters were higher than center-right voters in the traits of friendliness and openness and lower in energy and conscientiousness. Regarding values, center-left voters were higher than center-right voters in universalism, benevolence, and self-direction and lower in security, power, achievement, conformity, and tradition. Logistic regressions revealed that values explained substantial variance in past and future voting and in change of political choice, trumping personality traits. We discuss explanations for the primacy of values and implications for the social cognitive view of personality.