Institution
University of Calgary
Education•Calgary, Alberta, Canada•
About: University of Calgary is a education organization based out in Calgary, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 44284 authors who have published 104970 publications receiving 3669161 citations. The organization is also known as: U of C & UCalgary.
Papers published on a yearly basis
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TL;DR: A new model representing a dynamic approach that incorporates the consequences of repeated participation in sport, both with and without injury is outlined, which considers the implications of repeated exposure, whether such exposure produces adaptation, maladaptation, injury or complete/incomplete recovery from injury.
Abstract: :The purpose of this manuscript is to outline a new model representing a dynamic approach that incorporates the consequences of repeated participation in sport, both with and without injury. This model builds on the previous work, while emphasizing the fact that adaptations occur within the
493 citations
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TL;DR: An overview of well-differentiated neuroendocrine tumors of the stomach and pancreas is provided and consensus guidelines for the treatment of patients with these malignancies are described.
Abstract: Well-differentiated neuroendocrine tumors (NETs) of the stomach and pancreas represent 2 major subtypes of gastrointestinal NETs. Historically, there has been little consensus on the classification and management of patients with these tumor subtypes. We provide an overview of well-differentiated NETs of the stomach and pancreas and describe consensus guidelines for the treatment of patients with these malignancies.
493 citations
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TL;DR: This work has identified a previously unknown temporal expression program and expression hierarchy that matches the enzyme order in unbranched pathways of Escherichia coli and suggests that metabolic regulation networks are designed to generate precision promoter timing and activity programs that can be understood using the engineering principles of production pipelines.
Abstract: A primary goal of systems biology is to understand the design principles of the transcription networks that govern the timing of gene expression. Here we measured promoter activity for approximately 100 genes in parallel from living cells at a resolution of minutes and accuracy of 10%, based on GFP and Lux reporter libraries. Focusing on the amino-acid biosynthesis systems of Escherichia coli, we identified a previously unknown temporal expression program and expression hierarchy that matches the enzyme order in unbranched pathways. We identified two design principles: the closer the enzyme is to the beginning of the pathway, the shorter the response time of the activation of its promoter and the higher its maximal promoter activity. Mathematical analysis suggests that this 'just-in-time' (ref. 5) transcription program is optimal under constraints of rapidly reaching a production goal with minimal total enzyme production. Our findings suggest that metabolic regulation networks are designed to generate precision promoter timing and activity programs that can be understood using the engineering principles of production pipelines.
493 citations
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Yale University1, Semel Institute for Neuroscience and Human Behavior2, University of California, Irvine3, University of Calgary4, University of California, San Diego5, University of California, San Francisco6, University of North Carolina at Chapel Hill7, Beth Israel Deaconess Medical Center8, Emory University9
TL;DR: These findings demonstrate that the brain changes are not explained by exposure to antipsychotic drugs but likely play a role in psychosis pathophysiology.
493 citations
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University of New Hampshire1, Los Alamos National Laboratory2, University of Colorado Boulder3, The Aerospace Corporation4, Community emergency response team5, Rice University6, Southwest Research Institute7, National Oceanic and Atmospheric Administration8, British Antarctic Survey9, Dartmouth College10, Goddard Space Flight Center11, University of Calgary12, Massachusetts Institute of Technology13, University of Alberta14, Johns Hopkins University Applied Physics Laboratory15, University of California16
TL;DR: The Radiation Belt Storm Probes (RBSP)-Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains an innovative complement of particle instruments to ensure the highest quality measurements ever made in the inner magnetosphere and radiation belts as mentioned in this paper.
Abstract: The Radiation Belt Storm Probes (RBSP)-Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains an innovative complement of particle instruments to ensure the highest quality measurements ever made in the inner magnetosphere and radiation belts. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, are necessary for understanding the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA’s Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Magnetic Electron Ion Spectrometer (MagEIS), the Helium Oxygen Proton Electron (HOPE) sensor, and the Relativistic Electron Proton Telescope (REPT). Collectively they cover, continuously, the full electron and ion spectra from one eV to 10’s of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts. The instruments use those proven techniques along with innovative new designs, optimized for operation in the most extreme conditions in order to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. The design, fabrication and operation of ECT spaceflight instrumentation in the harsh radiation belt environment ensure that particle measurements have the fidelity needed for closure in answering key mission science questions. ECT instrument details are provided in companion papers in this same issue.
492 citations
Authors
Showing all 44775 results
Name | H-index | Papers | Citations |
---|---|---|---|
Meir J. Stampfer | 277 | 1414 | 283776 |
Zena Werb | 168 | 473 | 122629 |
William J. Sandborn | 162 | 1317 | 108564 |
Gregg C. Fonarow | 161 | 1676 | 126516 |
David W. Johnson | 160 | 2714 | 140778 |
Jerome I. Rotter | 156 | 1071 | 116296 |
Carl Nathan | 135 | 430 | 91535 |
Severine Vermeire | 134 | 1086 | 76352 |
Ian Ford | 134 | 678 | 85769 |
Jeffery D. Molkentin | 131 | 482 | 61594 |
Joseph P. Broderick | 130 | 504 | 72779 |
Shuai Liu | 129 | 1095 | 80823 |
Marcello Tonelli | 128 | 701 | 115576 |
Gary C. Curhan | 128 | 435 | 55348 |
James C. Paulson | 126 | 443 | 52152 |