University of Calgary

About: University of Calgary is a education organization based out in Calgary, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 44284 authors who have published 104970 publications receiving 3669161 citations. The organization is also known as: U of C & UCalgary.

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Abstract: We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.

Anaerobic threshold: the concept and methods of measurement.

Abstract: Resume The anaerobic threshold (AnT) is defined as the highest sustained intensity of exercise for which measurement of oxygen uptake can account for the entire energy requirement. At the AnT, the rate at which lactate appears in the blood will be equal to the rate of its disappear- ance. Although inadequate oxygen delivery may facilitate lactic acid production, there is no evidence that lactic acid production above the AnT results from inadequate oxygen deliv- ery. There are many reasons for trying to quantify this intensity of exercise, including as- sessment of cardiovascular or pulmonary health, evaluation of training programs, and cat- egorization of the intensity of exercise as mild, moderate, or intense. Several tests have been developed to determine the intensity of exercise associated with AnT: maximal lactate steady state, lactate minimum test, lactate threshold, OBLA, individual anaerobic thresh- old, and ventilatory threshold. Each approach permits an estimate of the intensity of exer- cise associated with AnT, but also has consistent and predictable error depending on proto- col and the criteria used to identify the appropriate intensity of exercise. These tests are valuable, but when used to predict AnT, the term that describes the approach taken should be used to refer to the intensity that has been identified, rather than to refer to this intensity as the AnT.