Institution
University of Georgia
Education•Athens, Georgia, United States•
About: University of Georgia is a education organization based out in Athens, Georgia, United States. It is known for research contribution in the topics: Population & Gene. The organization has 41934 authors who have published 93622 publications receiving 3713212 citations. The organization is also known as: UGA & Franklin College.
Topics: Population, Gene, Poison control, Context (language use), Genome
Papers published on a yearly basis
Papers
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TL;DR: The authors examined the work values of a nationally representative sample of U.S. high school seniors in 1976, 1991, and 2006 (N = 16,507) representing Baby Boomers, Generation X (GenX), and Generation Me (GenMe), also known as GenY, or Millennials).
1,224 citations
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TL;DR: It is concluded that the enumeration of white blood cells from blood smears can provide a reliable assessment of stress in all vertebrate taxa because of the universal and consistent nature of the haematological response to stress.
Abstract: Summary 1. A growing number of ecologists are turning to the enumeration of white blood cells from blood smears (leukocyte profiles) to assess stress in animals. There has been some inconsistency and controversy in the ecological literature, however, regarding their interpretation. The inconsistencies may stem partly from a lack of information regarding how stress affects leukocytes in different taxa, and partly from a failure on the part of researchers in one discipline to consult potentially informative literature from another. 2. Here, we seek to address both issues by reviewing the literature on the leukocyte response to stress, spanning the taxa of mammals (including humans), birds, amphibians, reptiles and fish. 3. We show that much of the early literature points to a close link between leukocyte profiles and glucocorticoid levels. Specifically, these hormones act to increase the number and percentage of neutrophils (heterophils in birds and reptiles), while decreasing the number and percentage of lymphocytes. This phenomenon is seen in all five vertebrate taxa in response to either natural stressors or exogenous administration of stress hormones. For the ecologist, therefore, high ratios of heterophils or neutrophils to lymphocytes (‘H : L’ or ‘N : L’ ratios) in blood samples reliably indicate high glucocorticoid levels. Furthermore, this close relationship between stress hormones and N : L or H : L ratios needs to be highlighted more prominently in haematological assessments of stress, as it aids the interpretation of results. 4. As with hormone assays, there are challenges to overcome in the use of leukocytes profiles to assess levels of stress; however, there are also advantages to this approach, and we outline each. Given the universal and consistent nature of the haematological response to stress, plus the overwhelming evidence from the veterinary, biomedical and ecological literature reviewed here, we conclude that this method can provide a reliable assessment of stress in all vertebrate taxa.
1,219 citations
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TL;DR: In insights into the role of alcohol consumption in the genetic architecture of hypertension, a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions is conducted.
Abstract: Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
1,218 citations
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1,217 citations
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TL;DR: Using the polymerase chain reaction and standard recombinant DNA techniques, a series of new multipurpose low-copy-number plasmids have been constructed, very useful for analyzing genes encoding proteins which are toxic in Escherichia coli in high copy number.
1,200 citations
Authors
Showing all 42268 results
Name | H-index | Papers | Citations |
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Rob Knight | 201 | 1061 | 253207 |
Feng Zhang | 172 | 1278 | 181865 |
Zhenan Bao | 169 | 865 | 106571 |
Carl W. Cotman | 165 | 809 | 105323 |
Yoshio Bando | 147 | 1234 | 80883 |
Mark Raymond Adams | 147 | 1187 | 135038 |
Han Zhang | 130 | 970 | 58863 |
Dmitri Golberg | 129 | 1024 | 61788 |
Godfrey D. Pearlson | 128 | 740 | 58845 |
Douglas E. Soltis | 127 | 612 | 67161 |
Richard A. Dixon | 126 | 603 | 71424 |
Ajit Varki | 124 | 542 | 58772 |
Keith A. Johnson | 120 | 798 | 51034 |
Gustavo E. Scuseria | 120 | 658 | 95195 |
Julian I. Schroeder | 120 | 315 | 50323 |