University of Hartford

About: University of Hartford is a education organization based out in West Hartford, Connecticut, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 1244 authors who have published 2481 publications receiving 48973 citations. The organization is also known as: UHart.

Diels–alder polymer of N‐(2‐anthryl)maleimide

Abstract: Preparation par trois methodes: chauffage direct dans le toluene, reaction a temperature ambiante en presence d'un acide de Lewis ou indirectement par reaction de l'amino-2 anthracene avec l'anhydride maleique dans le DMF a haute temperature

Prostate Cancer Diagnosis in the Clinic Using an 8-Protein Biomarker Panel.

Abstract: The inability to distinguish aggressive from indolent prostate cancer is a longstanding clinical problem. Prostate specific antigen (PSA) tests and digital rectal exams cannot differentiate these forms. Because only ∼10% of diagnosed prostate cancer cases are aggressive, existing practice often results in overtreatment including unnecessary surgeries that degrade patients' quality of life. Here, we describe a fast microfluidic immunoarray optimized to determine 8-proteins simultaneously in 5 μL of blood serum for prostate cancer diagnostics. Using polymeric horseradish peroxidase (poly-HRP, 400 HRPs) labels to provide large signal amplification and limits of detection in the sub-fg mL-1 range, a protocol was devised for the optimization of the fast, accurate assays of 100-fold diluted serum samples. Analysis of 130 prostate cancer patient serum samples revealed that some members of the protein panel can distinguish aggressive from indolent cancers. Logistic regression was used to identify a subset of the panel, combining biomarker proteins ETS-related gene protein (ERG), insulin-like growth factor-1 (IGF-1), pigment epithelial-derived factor (PEDF), and serum monocyte differentiation antigen (CD-14) to predict whether a given patient should be referred for biopsy, which gave a much better predictive accuracy than PSA alone. This represents the first prostate cancer blood test that can predict which patients will have a high biopsy Gleason score, a standard pathology score used to grade tumors.