University of Mons

About: University of Mons is a education organization based out in Mons, Belgium. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3073 authors who have published 9465 publications receiving 294776 citations.

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.

Abstract: p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in that sense. The most widely investigated compounds for this purpose are PRIMA-1 (p53 reactivation and induction of massive apoptosis )and PRIMA-1Met (APR-246), that are at an advanced stage of development, with several clinical trials in progress. Based on publications referenced in PubMed since 2002, here we review the reported effects of these compounds on cancer cells, with a specific focus on their ability of p53 reactivation, an overview of their unexpected anti-cancer effects, and a presentation of the investigated drug combinations.

Measurement of the W+W- cross section in pp collisions at s=8 TeVand limits on anomalous gauge couplings

Abstract: A measurement of the W boson pair production cross section in proton-proton collisions at √s = 8 TeV is presented. The data collected with the CMS detector at the LHC correspond to an integrated luminosity of 19.4 fb^(-1). The W^+W^− candidates are selected from events with two charged leptons, electrons or muons, and large missing transverse energy. The measured W^+W^− cross section is 60.1 ± 0.9(stat) ± 3.2 (exp) ± 3.1(theo)±1.6 (lumi)\,pb = 60.1 ± 4.8\,pb60.1 ± 0.9 (stat) ±3.2 (exp)±3.1 (theo) ± 1.6 (lumi)\,pb = 60.1 ± 4.8\, pb, consistent with the standard model prediction. The W^+W^− cross sections are also measured in two different fiducial phase space regions. The normalized differential cross section is measured as a function of kinematic variables of the final-state charged leptons and compared with several perturbative QCD predictions. Limits on anomalous gauge couplings associated with dimension-six operators are also given in the framework of an effective field theory. The corresponding 95 % confidence level intervals are −5.7