University of Tabriz

About: University of Tabriz is a education organization based out in Tabriz, Iran. It is known for research contribution in the topics: Population & Nanocomposite. The organization has 12141 authors who have published 20976 publications receiving 313982 citations.

QTL analysis of resistance to Fusarium head blight in wheat using a ‘Wangshuibai’‐derived population

Abstract: Fusarium head blight (FHB) is a devastating disease that reduces the yield, quality and economic value of wheat. For quantitative trait loci (QTL) analysis of resistance to FHB, F 3 plants and F 3:5 lines, derived from a 'Wangshuibai' (resistant)/'Seri82' (susceptible) cross, were spray inoculated during 2001 and 2002, respectively. Artificial inoculation was carried out under field conditions. Of 420 markers, 258 amplified fragment length polymorphism and 39 simple sequence repeat (SSR) markers were mapped and yielded 44 linkage groups covering a total genetic distance of 2554 cM. QTL analysis was based on the constructed linkage map and area under the disease progress curve. The analyses revealed a QTL in the map interval Xgwm533-Xs18/m12 on chromosome 3BS accounting for up to 17% of the phenotypic variation. In addition, a QTL was detected in the map interval Xgwm539-Xs15/m24 on chromosome 2DL explaining up to 11% of the phenotypic variation. The QTL alleles originated from 'Wangshuibai' and were lagged with SSR markers. Using these SSR markers would facilitate marker-assisted selection to improve FHB resistance in wheat.

New nanocomposites containing metal nanoparticles, carbon nanotube and polymer

Abstract: Metal-carbon nanotube-graft-polymer (MCNT-g-P) nanocomposites were synthesized and characterized successfully. In this work, multiwall carbon nanotubes (MWCNT) were opened using HNO3/H2SO4 mixture and filled by metal nanoparticles such as silver nanoparticles through wet chemistry method. Then MWCNT containing metal nanoparticles were used as macroinitiator for ring opening polymerization of e-caprolactone and MCNT-g-P nanocomposites were obtained. Length of grafted polymer arms onto the MWCNT was controlled using MWCNT/e-caprolactone ratio. Structure and properties of nanocomposites were evaluated by TEM, DSC, TGA, and spectroscopy methods.

Photodynamic N-TiO 2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells

Abstract: In this study, we used nitrogen-doped titanium dioxide (N-TiO2) NPs in conjugation with visible light, and show that both reactive oxygen species (ROS) and autophagy are induced by this novel NP-based photodynamic therapy (PDT) system. While well-dispersed N-TiO2 NPs (≤100 μg/ml) were inert, their photo-activation with visible light led to ROS-mediated autophagy in leukemia K562 cells and normal peripheral lymphocytes, and this increased in parallel with increasing NP concentrations and light doses. At a constant light energy (12 J/cm2), increasing N-TiO2 NP concentrations increased ROS levels to trigger autophagy-dependent megakaryocytic terminal differentiation in K562 cells. By contrast, an ROS challenge induced by high N-TiO2 NP concentrations led to autophagy-associated apoptotic cell death. Using chemical autophagy inhibitors (3-methyladenine and Bafilomycin A1), we confirmed that autophagy is required for both terminal differentiation and apoptosis induced by photo-activated N-TiO2. Pre-incubation of leukemic cells with ROS scavengers muted the effect of N-TiO2 NP-based PDT on cell fate, highlighting the upstream role of ROS in our system. In summary, PDT using N-TiO2 NPs provides an effective method of priming autophagy by ROS induction. The capability of photo-activated N-TiO2 NPs in obtaining desirable cellular outcomes represents a novel therapeutic strategy of cancer cells.