University of Trento

About: University of Trento is a education organization based out in Trento, Italy. It is known for research contribution in the topics: Population & Context (language use). The organization has 10527 authors who have published 30978 publications receiving 896614 citations. The organization is also known as: Universitá degli Studi di Trento & Universita degli Studi di Trento.

Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights.

Abstract: Shotgun metagenomic analysis of the human associated microbiome provides a rich set of microbial features for prediction and biomarker discovery in the context of human diseases and health conditions. However, the use of such high-resolution microbial features presents new challenges, and validated computational tools for learning tasks are lacking. Moreover, classification rules have scarcely been validated in independent studies, posing questions about the generality and generalization of disease-predictive models across cohorts. In this paper, we comprehensively assess approaches to metagenomics-based prediction tasks and for quantitative assessment of the strength of potential microbiome-phenotype associations. We develop a computational framework for prediction tasks using quantitative microbiome profiles, including species-level relative abundances and presence of strain-specific markers. A comprehensive meta-analysis, with particular emphasis on generalization across cohorts, was performed in a collection of 2424 publicly available metagenomic samples from eight large-scale studies. Cross-validation revealed good disease-prediction capabilities, which were in general improved by feature selection and use of strain-specific markers instead of species-level taxonomic abundance. In cross-study analysis, models transferred between studies were in some cases less accurate than models tested by within-study cross-validation. Interestingly, the addition of healthy (control) samples from other studies to training sets improved disease prediction capabilities. Some microbial species (most notably Streptococcus anginosus) seem to characterize general dysbiotic states of the microbiome rather than connections with a specific disease. Our results in modelling features of the “healthy” microbiome can be considered a first step toward defining general microbial dysbiosis. The software framework, microbiome profiles, and metadata for thousands of samples are publicly available at http://segatalab.cibio.unitn.it/tools/metaml.

Multi-scale Continuous CRFs as Sequential Deep Networks for Monocular Depth Estimation

Abstract: This paper addresses the problem of depth estimation from a single still image. Inspired by recent works on multi-scale convolutional neural networks (CNN), we propose a deep model which fuses complementary information derived from multiple CNN side outputs. Different from previous methods, the integration is obtained by means of continuous Conditional Random Fields (CRFs). In particular, we propose two different variations, one based on a cascade of multiple CRFs, the other on a unified graphical model. By designing a novel CNN implementation of mean-field updates for continuous CRFs, we show that both proposed models can be regarded as sequential deep networks and that training can be performed end-to-end. Through extensive experimental evaluation we demonstrate the effectiveness of the proposed approach and establish new state of the art results on publicly available datasets.

Automated composition of semantic web services into executable processes

Abstract: Different planning techniques have been applied to the problem of automated composition of web services. However, in realistic cases, this planning problem is far from trivial: the planner needs to deal with the nondeterministic behavior of web services, the partial observability of their internal status, and with complex goals expressing temporal conditions and preference requirements. We propose a planning technique for the automated composition of web services described in OWLS process models, which can deal effectively with nondeterminism, partial observability, and complex goals. The technique allows for the synthesis of plans that encode compositions of web services with the usual programming constructs, like conditionals and iterations. The generated plans can thus be translated into executable processes, e.g., BPEL4WS programs. We implement our solution in a planner and do some preliminary experimental evaluations that show the potentialities of our approach, and the gain in performance of automating the composition at the semantic level w.r.t. the automated composition at the level of executable processes.

Proposal for International Standardization of the Use of Lung Ultrasound for Patients With COVID-19: A Simple, Quantitative, Reproducible Method.

Abstract: Growing evidence is showing the usefulness of lung ultrasound in patients with the 2019 new coronavirus disease (COVID-19). Severe acute respiratory syndrome coronavirus 2 has now spread in almost every country in the world. In this study, we share our experience and propose a standardized approach to optimize the use of lung ultrasound in patients with COVID-19. We focus on equipment, procedure, classification, and data sharing.