Institution
University of Trento
Education•Trento, Italy•
About: University of Trento is a education organization based out in Trento, Italy. It is known for research contribution in the topics: Population & Context (language use). The organization has 10527 authors who have published 30978 publications receiving 896614 citations. The organization is also known as: Universitá degli Studi di Trento & Universita degli Studi di Trento.
Papers published on a yearly basis
Papers
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TL;DR: This large analysis integrating mCRPC genomics with histology and clinical outcomes identifies RB1 genomic alteration as a potent predictor of poor outcome, and is a community resource for further interrogation of clinical and molecular associations.
Abstract: Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcriptomic analysis of 429 patients with metastatic castration-resistant prostate cancer (mCRPC) linked with longitudinal clinical outcomes, integrating findings from whole-exome, transcriptome, and histologic analysis. For 128 patients treated with a first-line next-generation androgen receptor signaling inhibitor (ARSI; abiraterone or enzalutamide), we examined the association of 18 recurrent DNA- and RNA-based genomic alterations, including androgen receptor (AR) variant expression, AR transcriptional output, and neuroendocrine expression signatures, with clinical outcomes. Of these, only RB1 alteration was significantly associated with poor survival, whereas alterations in RB1, AR, and TP53 were associated with shorter time on treatment with an ARSI. This large analysis integrating mCRPC genomics with histology and clinical outcomes identifies RB1 genomic alteration as a potent predictor of poor outcome, and is a community resource for further interrogation of clinical and molecular associations.
712 citations
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TL;DR: The analysis singles out the class of entangled states which are useful to overcome classical phase sensitivity in metrology and sensors and studies the creation of useful entangled states by the nonlinear dynamical evolution of two decoupled Bose-Einstein condensates or trapped ions.
Abstract: We show that the quantum Fisher information provides a sufficient condition to recognize multi-particle entanglement in a N qubit state. The same criterion gives a necessary and sufficient condition for sub shot-noise phase sensitivity in the estimation of a collective rotation angle θ . The analysis therefore singles out the class of entangled states which are {\it useful} to overcome classical phase sensitivity in metrology and sensors. We finally study the creation of useful entangled states by the non-linear dynamical evolution of two decoupled Bose-Einstein condensates or trapped ions.
703 citations
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TL;DR: In this paper, a construction of virtual fundamental classes of certain types of moduli spaces is proposed, where the fundamental classes can be expressed as a set of classes of modulus spaces.
Abstract: We suggest a construction of virtual fundamental classes of certain types of moduli spaces.
702 citations
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University of Göttingen1, City College of New York2, University of São Paulo3, University of Toronto4, Aalborg University5, University of Erlangen-Nuremberg6, Greifswald University Hospital7, Spaulding Rehabilitation Hospital8, Medical University of South Carolina9, University of Pennsylvania10, Technische Universität Ilmenau11, University of Oldenburg12, École Polytechnique Fédérale de Lausanne13, Paris 12 Val de Marne University14, University of New South Wales15, University of Aberdeen16, University of Trento17, University of Lisbon18, University of Kiel19, Technical University of Dortmund20, Ruhr University Bochum21, Ludwig Maximilian University of Munich22, Beth Israel Deaconess Medical Center23, Mannheim University of Applied Sciences24, University of Siena25, The Catholic University of America26, University College London27, University of Copenhagen28, Fukushima Medical University29, Massachusetts Institute of Technology30, University of Tübingen31
TL;DR: Structured interviews are provided and recommend their use in future controlled studies, in particular when trying to extend the parameters applied, to discuss recent regulatory issues, reporting practices and ethical issues.
699 citations
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TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.
Abstract: Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route. (Re)discovery and characterization of meningeal lymphatic vessels has prompted an assessment of their role in waste clearance from the CNS. Here we show that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice. Impairment of meningeal lymphatic function slows paravascular influx of macromolecules into the brain and efflux of macromolecules from the interstitial fluid, and induces cognitive impairment in mice. Treatment of aged mice with vascular endothelial growth factor C enhances meningeal lymphatic drainage of macromolecules from the cerebrospinal fluid, improving brain perfusion and learning and memory performance. Disruption of meningeal lymphatic vessels in transgenic mouse models of Alzheimer’s disease promotes amyloid-β deposition in the meninges, which resembles human meningeal pathology, and aggravates parenchymal amyloid-β accumulation. Meningeal lymphatic dysfunction may be an aggravating factor in Alzheimer’s disease pathology and in age-associated cognitive decline. Thus, augmentation of meningeal lymphatic function might be a promising therapeutic target for preventing or delaying age-associated neurological diseases.
694 citations
Authors
Showing all 10758 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Jie Zhang | 178 | 4857 | 221720 |
Richard B. Lipton | 176 | 2110 | 140776 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
J. N. Butler | 172 | 2525 | 175561 |
Andrea Bocci | 172 | 2402 | 176461 |
P. Chang | 170 | 2154 | 151783 |
Bradley Cox | 169 | 2150 | 156200 |
Marc Weber | 167 | 2716 | 153502 |
Guenakh Mitselmakher | 165 | 1951 | 164435 |
Brian L Winer | 162 | 1832 | 128850 |
J. S. Lange | 160 | 2083 | 145919 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Darien Wood | 160 | 2174 | 136596 |
Robert Stone | 160 | 1756 | 167901 |