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Showing papers by "University of Warsaw published in 2021"


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1428 moreInstitutions (155)
TL;DR: In this article, the population of 47 compact binary mergers detected with a false-alarm rate of 0.614 were dynamically assembled, and the authors found that the BBH rate likely increases with redshift, but not faster than the star formation rate.
Abstract: We report on the population of 47 compact binary mergers detected with a false-alarm rate of 0.01 are dynamically assembled. Third, we estimate merger rates, finding RBBH = 23.9-+8.614.3 Gpc-3 yr-1 for BBHs and RBNS = 320-+240490 Gpc-3 yr-1 for binary neutron stars. We find that the BBH rate likely increases with redshift (85% credibility) but not faster than the star formation rate (86% credibility). Additionally, we examine recent exceptional events in the context of our population models, finding that the asymmetric masses of GW190412 and the high component masses of GW190521 are consistent with our models, but the low secondary mass of GW190814 makes it an outlier.

468 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1692 moreInstitutions (195)
TL;DR: In this article, the authors reported the observation of gravitational waves from two compact binary coalescences in LIGO's and Virgo's third observing run with properties consistent with neutron star-black hole (NSBH) binaries.
Abstract: We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses 8.9−1.5+1.2 and 1.9−0.2+0.3M⊙ , whereas the source of GW200115 has component masses 5.7−2.1+1.8 and 1.5−0.3+0.7M⊙ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are 280−110+110 and 300−100+150Mpc , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of 45−33+75Gpc−3yr−1 when assuming that GW200105 and GW200115 are representative of the NSBH population or 130−69+112Gpc−3yr−1 under the assumption of a broader distribution of component masses.

374 citations


Journal ArticleDOI
Nabila Aghanim1, Yashar Akrami2, Yashar Akrami3, Yashar Akrami4  +229 moreInstitutions (70)
TL;DR: Aghanim et al. as mentioned in this paper used the same data set to derive a 95% upper bound of 0.020 using the principal component analysis (PCA) model and uniform priors on the PCA mode amplitudes.
Abstract: Author(s): Aghanim, N; Akrami, Y; Ashdown, M; Aumont, J; Baccigalupi, C; Ballardini, M; Banday, AJ; Barreiro, RB; Bartolo, N; Basak, S; Battye, R; Benabed, K; Bernard, JP; Bersanelli, M; Bielewicz, P; Bock, JJ; Bond, JR; Borrill, J; Bouchet, FR; Boulanger, F; Bucher, M; Burigana, C; Butler, RC; Calabrese, E; Cardoso, JF; Carron, J; Challinor, A; Chiang, HC; Chluba, J; Colombo, LPL; Combet, C; Contreras, D; Crill, BP; Cuttaia, F; De Bernardis, P; De Zotti, G; Delabrouille, J; Delouis, JM; DI Valentino, E; DIego, JM; Dore, O; Douspis, M; Ducout, A; Dupac, X; Dusini, S; Efstathiou, G; Elsner, F; Enslin, TA; Eriksen, HK; Fantaye, Y; Farhang, M; Fergusson, J; Fernandez-Cobos, R; Finelli, F; Forastieri, F; Frailis, M; Fraisse, AA; Franceschi, E; Frolov, A; Galeotta, S; Galli, S; Ganga, K; Genova-Santos, RT; Gerbino, M; Ghosh, T; Gonzalez-Nuevo, J; Gorski, KM; Gratton, S; Gruppuso, A; Gudmundsson, JE; Hamann, J; Handley, W; Hansen, FK; Herranz, D; Hildebrandt, SR; Hivon, E; Huang, Z; Jaffe, AH; Jones, WC; Karakci, A; Keihanen, E; Keskitalo, R; Kiiveri, K; Kim, J; Kisner, TS | Abstract: In the original version, the bounds given in Eqs. (87a) and (87b) on the contribution to the early-time optical depth, (15,30), contained a numerical error in deriving the 95th percentile from the Monte Carlo samples. The corrected 95% upper bounds are: τ(15,30) l 0:018 (lowE, flat τ(15, 30), FlexKnot), (1) τ(15, 30) l 0:023 (lowE, flat knot, FlexKnot): (2) These bounds are a factor of 3 larger than the originally reported results. Consequently, the new bounds do not significantly improve upon previous results from Planck data presented in Millea a Bouchet (2018) as was stated, but are instead comparable. Equations (1) and (2) give results that are now similar to those of Heinrich a Hu (2021), who used the same Planck 2018 data to derive a 95% upper bound of 0.020 using the principal component analysis (PCA) model and uniform priors on the PCA mode amplitudes.

344 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1335 moreInstitutions (144)
TL;DR: The data recorded by these instruments during their first and second observing runs are described, including the gravitational-wave strain arrays, released as time series sampled at 16384 Hz.

320 citations


Journal ArticleDOI
TL;DR: The NANOGrav Collaboration has recently reported strong evidence for a stochastic common-spectrum process, which is interpreted as a SGWB in the framework of cosmic strings, which would correspond to a string tension Gμ∈(4×10^{-11}, 10^{-10}) at the 68% confidence level.
Abstract: Pulsar timing data used to provide upper limits on a possible stochastic gravitational wave background (SGWB). However, the NANOGrav Collaboration has recently reported strong evidence for a stochastic common-spectrum process, which we interpret as a SGWB in the framework of cosmic strings. The possible NANOGrav signal would correspond to a string tension $G\ensuremath{\mu}\ensuremath{\in}(4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}11},{10}^{\ensuremath{-}10})$ at the 68% confidence level, with a different frequency dependence from supermassive black hole mergers. The SGWB produced by cosmic strings with such values of $G\ensuremath{\mu}$ would be beyond the reach of LIGO, but could be measured by other planned and proposed detectors such as SKA, LISA, TianQin, AION-1 km, AEDGE, Einstein Telescope, and Cosmic Explorer.

186 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3  +1273 moreInstitutions (140)
TL;DR: In this article, the first and second observing runs of the Advanced LIGO and Virgo detector network were used to obtain the first standard-siren measurement of the Hubble constant (H 0).
Abstract: This paper presents the gravitational-wave measurement of the Hubble constant (H 0) using the detections from the first and second observing runs of the Advanced LIGO and Virgo detector network. The presence of the transient electromagnetic counterpart of the binary neutron star GW170817 led to the first standard-siren measurement of H 0. Here we additionally use binary black hole detections in conjunction with galaxy catalogs and report a joint measurement. Our updated measurement is H 0 = km s−1 Mpc−1 (68.3% of the highest density posterior interval with a flat-in-log prior) which is an improvement by a factor of 1.04 (about 4%) over the GW170817-only value of km s−1 Mpc−1. A significant additional contribution currently comes from GW170814, a loud and well-localized detection from a part of the sky thoroughly covered by the Dark Energy Survey. With numerous detections anticipated over the upcoming years, an exhaustive understanding of other systematic effects are also going to become increasingly important. These results establish the path to cosmology using gravitational-wave observations with and without transient electromagnetic counterparts.

171 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1678 moreInstitutions (193)
TL;DR: In this article, the authors report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO's and Advanced Virgo's third observing run (O3) combined with upper limits from the earlier O1 and O2 runs.
Abstract: We report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO’s and Advanced Virgo’s third observing run (O3) combined with upper limits from the earlier O1 and O2 runs. Unlike in previous observing runs in the advanced detector era, we include Virgo in the search for the GWB. The results of the search are consistent with uncorrelated noise, and therefore we place upper limits on the strength of the GWB. We find that the dimensionless energy density Ω GW ≤ 5.8 × 10 − 9 at the 95% credible level for a flat (frequency-independent) GWB, using a prior which is uniform in the log of the strength of the GWB, with 99% of the sensitivity coming from the band 20–76.6 Hz; Ω GW ( f ) ≤ 3.4 × 10 − 9 at 25 Hz for a power-law GWB with a spectral index of 2 / 3 (consistent with expectations for compact binary coalescences), in the band 20–90.6 Hz; and Ω GW ( f ) ≤ 3.9 × 10 − 10 at 25 Hz for a spectral index of 3, in the band 20–291.6 Hz. These upper limits improve over our previous results by a factor of 6.0 for a flat GWB, 8.8 for a spectral index of 2 / 3 , and 13.1 for a spectral index of 3. We also search for a GWB arising from scalar and vector modes, which are predicted by alternative theories of gravity; we do not find evidence of these, and place upper limits on the strength of GWBs with these polarizations. We demonstrate that there is no evidence of correlated noise of magnetic origin by performing a Bayesian analysis that allows for the presence of both a GWB and an effective magnetic background arising from geophysical Schumann resonances. We compare our upper limits to a fiducial model for the GWB from the merger of compact binaries, updating the model to use the most recent data-driven population inference from the systems detected during O3a. Finally, we combine our results with observations of individual mergers and show that, at design sensitivity, this joint approach may yield stronger constraints on the merger rate of binary black holes at z ≳ 2 than can be achieved with individually resolved mergers alone.

146 citations


Journal ArticleDOI
R. L. Smart1, L. M. Sarro2, Jan Rybizki3, Céline Reylé4  +455 moreInstitutions (82)
TL;DR: In this paper, a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3 is presented, which contains at least 92% of stars of stellar type M9 within 100pc of the sun.
Abstract: Aims. We produce a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use.Methods. Theselection of objects within 100 pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100 pc is included in the catalogue.Results. We have produced a catalogue of 331 312 objects that we estimate contains at least 92% of stars of stellar type M9 within 100 pc of the Sun. We estimate that 9% of the stars in this catalogue probably lie outside 100 pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of Gaia Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10 pc of the Sun.Conclusions. We provide the community with a large, well-characterised catalogue of objects in the solar neighbourhood. This is a primary benchmark for measuring and understanding fundamental parameters and descriptive functions in astronomy.

137 citations


Journal ArticleDOI
TL;DR: In this paper, the Parkes Pulsar Timing Array (PTA) data were used to detect the spatial correlation of the Hellings-downs signature of the gravitational wave background.
Abstract: A nanohertz-frequency stochastic gravitational-wave background can potentially be detected through the precise timing of an array of millisecond pulsars. This background produces low-frequency noise in the pulse arrival times that would have a characteristic spectrum common to all pulsars and a well-defined spatial correlation. Recently the North American Nanohertz Observatory for Gravitational Waves collaboration (NANOGrav) found evidence for the common-spectrum component in their 12.5-year data set. Here we report on a search for the background using the second data release of the Parkes Pulsar Timing Array. If we are forced to choose between the two NANOGrav models $\unicode{x2014}$ one with a common-spectrum process and one without $\unicode{x2014}$ we find strong support for the common-spectrum process. However, in this paper, we consider the possibility that the analysis suffers from model misspecification. In particular, we present simulated data sets that contain noise with distinctive spectra but show strong evidence for a common-spectrum process under the standard assumptions. The Parkes data show no significant evidence for, or against, the spatially correlated Hellings-Downs signature of the gravitational-wave background. Assuming we did observe the process underlying the spatially uncorrelated component of the background, we infer its amplitude to be $A = 2.2^{+0.4}_{-0.3} \times 10^{-15}$ in units of gravitational-wave strain at a frequency of $1\, \text{yr}^{-1}$. Extensions and combinations of existing and new data sets will improve the prospects of identifying spatial correlations that are necessary to claim a detection of the gravitational-wave background.

136 citations


Journal ArticleDOI
TL;DR: In this article, the authors present a review of peptide-based therapeutics, focusing on the current state-of-the-art short peptidebased therapeutical developments, as a celebration of 100 years peptide therapeutics since the commencement of insulin therapy in the 1920s.
Abstract: Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide "drugs" initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

129 citations


Journal ArticleDOI
TL;DR: In this article, Verspagen, van Herk and van Wijk present a collection of essays with the same authors, including a discussion of the role of gender in the relationship between women and women's empowerment.
Abstract: Output Status: Forthcoming/Available Online Additional co-authors: Jolanda Verspagen, Maria van Herk, Maria G. Antoniou, Nikoletta Tsiarta, Valerie McCarthy, Victor C. Perello, Danielle Machado-Vieira, Alinne Gurjao de Oliveira, Dubravka Spoljaric Maronic, Filip Stevic, Tanja Žuna Pfeiffer, Itana Bokan Vucelic, Petar Žutinic, Marija Gligora Udovic, Anđelka Plenkovic-Moraj, Ludek Blaha, Rodan Geris, Marketa Frankova, Kirsten Seestern Christoffersen, Trine Perlt Warming, Tonu Feldmann, Alo Laas, Kristel Panksep, Lea Tuvikene, Kersti Kangro, Judita Koreiviene, Jurate Karosiene, Jurate Kasperoviciene, Ksenija Savadova-Ratkus, Irma Vitonyte, Kerstin Haggqvist, Pauliina Salmi, Lauri Arvola, Karl Rothhaupt, Christos Avagianos, Triantafyllos Kaloudis, Spyros Gkelis, Manthos Panou, Theodoros Triantis, Sevasti-Kiriaki Zervou, Anastasia Hiskia, Ulrike Obertegger, Adriano Boscaini, Giovanna Flaim, Nico Salmaso, Leonardo Cerasino, Sigrid Haande, Birger Skjelbred, Magdalena Grabowska, Maciej Karpowicz, Damian Chmura, Lidia Nawrocka, Justyna Kobos, Hanna Mazur-Marzec, Pablo Alcaraz-Parraga, Elzbieta Wilk-Wozniak, Wojciech Krzton, Edward Walusiak, Ilona Gagala-Borowska, Joana Mankiewicz-Boczek, Magdalena Toporowska, Barbara Pawlik-Skowronska, Michal Niedzwiecki, Wojciech Peczula, Agnieszka Napiorkowska-Krzebietke, Julita Dunalska, Justyna Sienska, Daniel Szymanski, Marek Kruk, Agnieszka Budzynska, Ryszard Goldyn, Anna Kozak, Joanna Rosinska, Elzbieta Szeląg-Wasielewska, Piotr Domek, Natalia Jakubowska-Krepska, Kinga Kwasizur, Beata Messyasz, Aleksandra Pelechata, Mariusz Pelechaty, Mikolaj Kokocinski, Beata Madrecka-Witkowska, Iwona Kostrzewska-Szlakowska, Magdalena Frąk, Agnieszka Bankowska-Sobczak, Michal Wasilewicz, Agnieszka Ochocka, Agnieszka Pasztaleniec, Iwona Jasser, Ana M. Antao-Geraldes, Manel Leira, Vitor Vasconcelos, Joao Morais, Micaela Vale, Pedro M. Raposeiro, Vitor Goncalves, Boris Aleksovski, Svetislav Krstic, Hana Nemova, Iveta Drastichova, Lucia Chomova, Spela Remec-Rekar, Tina Elersek, Lars-Anders Hansson, Pablo Urrutia-Cordero, Andrea G. Bravo, Moritz Buck, William Colom-Montero, Kristiina Mustonen, Don Pierson, Yang Yang, Christine Edwards, Hannah Cromie, Jordi Delgado-Martin, David Garcia, Jose Luis Cereijo, Joan Goma, Mari Carmen Trapote, Teresa Vegas-Vilarrubia, Biel Obrador, Ana Garcia-Murcia, Monserrat Real, Elvira Romans, Jordi Noguero-Ribes, David Parreno Duque, Elisabeth Fernandez-Moran, Barbara Ubeda, Jose Angel Galvez, Nuria Catalan, Carmen Perez-Martinez, Eloisa Ramos-Rodriguez, Carmen Cillero-Castro, Enrique Moreno-Ostos, Jose Maria Blanco, Valeriano Rodriguez, Jorge Juan Montes-Perez, Roberto L. Palomino, Estela Rodriguez-Perez, Armand Hernandez, Rafael Carballeira, Antonio Camacho, Antonio Picazo, Carlos Rochera, Anna C. Santamans, Carmen Ferriol, Susana Romo, Juan Miguel Soria, Arda Ozen, Tunay Karan, Nilsun Demir, Meryem Beklioglu, Nur Filiz, Eti Levi, Ugur Iskin, Gizem Bezirci, Ulku Nihan Tavsanoglu, Kemal Celik, Koray Ozhan, Nusret Karakaya, Mehmet Ali Turan Kocer, Mete Yilmaz, Faruk Maras¸lioglu, Ozden Fakioglu, Elif Neyran Soylu, Meral Apaydin Yagci, Sakir Cinar, Kadir Capkin, Abdulkadir Yagci, Mehmet Cesur, Fuat Bilgin, Cafer Bulut, Rahmi Uysal, Koker Latife, Reyhan Akcaalan, Meric Albay, Mehmet Tahir Alp, Korhan Ozkan, Tugba Ongun Sevindik, Hatice Tunca, Burcin Onem, Hans Paerl, Cayelan C. Carey, Bastiaan W. Ibelings

Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Thomas Bergauer1  +2405 moreInstitutions (229)
TL;DR: In this paper, the performance of the reconstruction and identification algorithms for electrons and photons with the CMS experiment at the LHC is presented, based on proton-proton collision data collected at a center-of-mass energy of 13 TeV and recorded in 2016-2018, corresponding to an integrated luminosity of 136 fb$^{-1}$.
Abstract: The performance is presented of the reconstruction and identification algorithms for electrons and photons with the CMS experiment at the LHC. The reported results are based on proton-proton collision data collected at a center-of-mass energy of 13 TeV and recorded in 2016-2018, corresponding to an integrated luminosity of 136 fb$^{-1}$. Results obtained from lead-lead collision data collected at $\sqrt{s_\mathrm{NN}}=$ 5.02 TeV are also presented. Innovative techniques are used to reconstruct the electron and photon signals in the detector and to optimize the energy resolution. Events with electrons and photons in the final state are used to measure the energy resolution and energy scale uncertainty in the recorded events. The measured energy resolution for electrons produced in Z boson decays in proton-proton collision data ranges from 2 to 5%, depending on electron pseudorapidity and energy loss through bremsstrahlung in the detector material. The energy scale in the same range of energies is measured with an uncertainty smaller than 0.1 (0.3)% in the barrel (endcap) region in proton-proton collisions and better than 1 (3)% in the barrel (endcap) region in heavy ion collisions. The timing resolution for electrons from Z boson decays with the full 2016-2018 proton-proton collision data set is measured to be 200 ps.

Journal ArticleDOI
TL;DR: In this article, the anomalous Hall effect was shown to be present in a three-dimensional topological magnetic superlattice structure when the Fermi energy is tuned into the correct energy window.
Abstract: The quantum anomalous Hall effect1,2 is a fundamental transport response of a topological insulator in zero magnetic field. Its physical origin is a result of an intrinsically inverted electronic band structure and ferromagnetism3, and its most important manifestation is the dissipationless flow of chiral charge currents at the edges of the system4, a property that has the potential to transform future quantum electronics5,6. Here, we report a Berry-curvature-driven4,7 anomalous Hall regime at temperatures of several Kelvin in the magnetic topological bulk crystals in which Mn ions self-organize into a period-ordered MnBi2Te4/Bi2Te3 superlattice. Robust ferromagnetism of the MnBi2Te4 monolayers opens a surface gap8–10, and when the Fermi level is tuned to be within this gap, the anomalous Hall conductance reaches an e2/h quantization plateau, which is a clear indication of chiral transport through the edge states. The quantization in this regime is not obstructed by the bulk conduction channels and therefore should be present in a broad family of topological magnets. A three-dimensional topological magnetic superlattice structure exhibits the quantum anomalous Hall effect when the Fermi energy is tuned into the correct energy window.


Journal ArticleDOI
Ilya M. Veer1, Antje Riepenhausen1, Matthias Zerban2, Carolin Wackerhagen1, Lara M. Puhlmann3, Lara M. Puhlmann4, Haakon G. Engen5, Haakon G. Engen2, Göran Köber6, Sophie Alida Bögemann7, Jeroen Weermeijer8, Aleksandra Uściłko9, Netali Mor10, Netali Mor11, Marta Anna Marciniak12, Adrian Dahl Askelund5, Abbas Al-Kamel13, Sarah Ayash4, Giulia Barsuola14, Vaida Bartkute-Norkuniene, Simone Battaglia15, Yaryna Bobko, Sven Bölte16, Sven Bölte17, Paolo Cardone4, Edita Chvojkova18, Kaja Damnjanović19, Joana De Calheiros Velozo8, Lena de Thurah8, Yacila I Deza-Araujo20, Annika Dimitrov1, Kinga Farkas21, Kinga Farkas22, Clémence Feller20, Mary Gazea, Donya Gilan4, Donya Gilan2, Vedrana Gnjidić23, Michal Hajdúk24, Anu P. Hiekkaranta8, Live Skow Hofgaard5, Laura Ilen20, Zuzana Kasanova8, Mohsen Khanpour25, Bobo Hi-Po Lau26, Dionne B. Lenferink7, Thomas B Lindhardt, Dávid Á. Magas22, Julian Mituniewicz9, Laura Moreno-López27, Sofiia Muzychka, Maria Ntafouli28, Aet O'Leary29, Ilenia Paparella30, Nele Põldver29, Aki Rintala31, Aki Rintala8, Natalia Robak9, Anna M Rosická32, Espen Røysamb5, Siavash Sadeghi2, Maude Schneider20, Roma Siugzdaite33, Roma Siugzdaite14, Mirta Stantic34, Ana Teixeira8, Ana Todorovic34, Wendy W.N. Wan35, Rolf van Dick36, Klaus Lieb2, Klaus Lieb4, Birgit Kleim12, Erno J. Hermans7, Dorota Kobylińska9, Talma Hendler, Harald Binder6, Inez Myin-Germeys8, Judith M.C. van Leeuwen7, Oliver Tüscher4, Oliver Tüscher2, Kenneth S. L. Yuen4, Kenneth S. L. Yuen2, Henrik Walter1, Raffael Kalisch2, Raffael Kalisch4 
TL;DR: In this article, a cross-sectional online survey conducted in 24 languages during the most intense phase of the lockdown in Europe (22 March to 19 April) in a convenience sample of N = 15,970 adults was used to assess resilience factors, exposure to Corona crisis-specific and general stressors, as well as internalizing symptoms.
Abstract: The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resilience refers to the maintenance of mental health despite adversity. To gain mechanistic insights about the relationship between described psycho-social resilience factors and resilience specifically in the current crisis, we assessed resilience factors, exposure to Corona crisis-specific and general stressors, as well as internalizing symptoms in a cross-sectional online survey conducted in 24 languages during the most intense phase of the lockdown in Europe (22 March to 19 April) in a convenience sample of N = 15,970 adults. Resilience, as an outcome, was conceptualized as good mental health despite stressor exposure and measured as the inverse residual between actual and predicted symptom total score. Preregistered hypotheses (osf.io/r6btn) were tested with multiple regression models and mediation analyses. Results confirmed our primary hypothesis that positive appraisal style (PAS) is positively associated with resilience (p < 0.0001). The resilience factor PAS also partly mediated the positive association between perceived social support and resilience, and its association with resilience was in turn partly mediated by the ability to easily recover from stress (both p < 0.0001). In comparison with other resilience factors, good stress response recovery and positive appraisal specifically of the consequences of the Corona crisis were the strongest factors. Preregistered exploratory subgroup analyses (osf.io/thka9) showed that all tested resilience factors generalize across major socio-demographic categories. This research identifies modifiable protective factors that can be targeted by public mental health efforts in this and in future pandemics.

Journal ArticleDOI
B. Abi1, R. Acciarri2, M. A. Acero3, George Adamov4  +979 moreInstitutions (156)
TL;DR: Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.
Abstract: The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.

Journal ArticleDOI
TL;DR: Knowing which attitudes may be associated with the endorsement of specific conspiracy theories can contribute to counteracting their negative consequences during crises, demonstrating the importance of considering the content of various conspiracy theories when studying their social effects and potential causes.


Journal ArticleDOI
TL;DR: Deteriorating economic conditions were associated with a stronger decline in fertility during the economic recession as compared with the pre-recession period, suggesting the salience of factors such as broader perception of uncertainty that could not be captured in models and which rose to prominence during the Great Recession.
Abstract: This study investigates how the changes in labour market conditions and economic growth were associated with fertility before and during the Great Recession in Europe in 2002–2014. In contrast to previous studies, which largely concentrated at the country level, we use data for 251 European regions in 28 European Union (EU) member states prior to the withdrawal of the United Kingdom in January 2020. We apply three-level growth-curve model which allows for a great deal of flexibility in modelling temporal change while controlling for variation in economic conditions across regions and countries. Our findings show that fertility decline was strongly related to unemployment increase; this relationship was significant at different reproductive ages. Deteriorating economic conditions were associated with a stronger decline in fertility during the economic recession as compared with the pre-recession period. This evidence suggests the salience of factors such as broader perception of uncertainty that we could not capture in our models and which rose to prominence during the Great Recession. Furthermore, strongest fertility declines were observed in Southern Europe, Ireland and parts of Central and Eastern Europe, i.e. countries and regions where labour market conditions deteriorated most during the recession period. In Western Europe, and especially in the Nordic countries, fertility rates were not closely associated with the recession indicators.

Journal ArticleDOI
13 Jan 2021-Vaccine
TL;DR: In this article, the authors surveyed a sample of adult Polish citizens (n = 1066) and compared it with the data on international COVID-19 vaccine reluctance, concluding that a 67% herd immunity may be possible only if mandatory preventive vaccination programs start early and are combined with coordinated education efforts supported by legislative power and social campaigns.

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Bjorn Stevens1, Sandrine Bony, David Farrell2, Felix Ament  +274 moreInstitutions (51)
TL;DR: The recent EUREC$^4$A campaign as discussed by the authors was a turning point in our ability to study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper ocean processes or the life cycle of particulate matter.
Abstract: The science guiding the EUREC$^4$A campaign and its measurements is presented. EUREC$^4$A comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic – eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC$^4$A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200 km) and larger (500 km) scales, roughly 400 h of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced groundbased cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10 000 profiles), lower atmosphere (continuous profiling), and along the air–sea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC$^4$A explored – from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview of EUREC$^4$A’s outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement

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TL;DR: In this paper, evidence for Higgs boson decay to a pair of muons was presented, which was performed using proton-proton collision data at 13 TeV, corresponding to an integrated luminosity of 137 fb$−1}, recorded by the CMS experiment at the CERN LHC.
Abstract: Evidence for Higgs boson decay to a pair of muons is presented. This result combines searches in four exclusive categories targeting the production of the Higgs boson via gluon fusion, via vector boson fusion, in association with a vector boson, and in association with a top quark-antiquark pair. The analysis is performed using proton-proton collision data at $ \sqrt{s} $ = 13 TeV, corresponding to an integrated luminosity of 137 fb$^{−1}$, recorded by the CMS experiment at the CERN LHC. An excess of events over the back- ground expectation is observed in data with a significance of 3.0 standard deviations, where the expectation for the standard model (SM) Higgs boson with mass of 125.38 GeV is 2.5. The combination of this result with that from data recorded at $ \sqrt{s} $ = 7 and 8 TeV, corresponding to integrated luminosities of 5.1 and 19.7 fb$^{−1}$, respectively, increases both the expected and observed significances by 1%. The measured signal strength, relative to the SM prediction, is $ {1.19}_{-0.39}^{+0.40}{\left(\mathrm{stat}\right)}_{-0.14}^{+0.15}\left(\mathrm{syst}\right) $. This result constitutes the first evidence for the decay of the Higgs boson to second generation fermions and is the most precise measurement of the Higgs boson coupling to muons reported to date.[graphic not available: see fulltext]

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01 Mar 2021-Viruses
TL;DR: The SARS-CoV-2 variant of concern (VOC)-202012/01 (also known as B.1.7), first collected in United Kingdom on 20 September 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS CoV2 genomes sequenced in England.
Abstract: The novel SARS-CoV-2 Variant of Concern (VOC)-202012/01 (also known as B.1.1.7), first collected in United Kingdom on 20 September 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS-CoV-2 genomes sequenced in England. The VOC has been detected in 40 out of 46 countries that reported at least 50 genomes in January 2021. We have estimated that the replicative advantage of the VOC is in the range 1.83-2.18 [95% CI: 1.71-2.40] with respect to the 20A.EU1 variant that dominated in England in November 2020, and in range 1.65-1.72 [95% CI: 1.46-2.04] in Wales, Scotland, Denmark, and USA. As the VOC strain will likely spread globally towards fixation, it is important to monitor its molecular evolution. We have estimated growth rates of expanding mutations acquired by the VOC lineage to find that the L18F substitution in spike has initiated a fast growing VOC substrain. The L18F substitution is of significance because it has been found to compromise binding of neutralizing antibodies. Of concern are immune escape mutations acquired by the VOC: E484K, F490S, S494P (in the receptor binding motif of spike) and Q677H, Q675H (in the proximity of the polybasic cleavage site at the S1/S2 boundary). These mutants may hinder efficiency of existing vaccines and expand in response to the increasing after-infection or vaccine-induced seroprevalence.

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TL;DR: Investigation of different factors associated with coronavirus-related anxiety during the COVID-19 outbreak in Poland revealed that anxiety in response to the CO VID-19 was common in the sample and major predictors of higher anxiety related to the pandemic outbreak included demographic factors.

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01 Feb 2021-Vaccine
TL;DR: In this article, the authors present a set of actions provided by independent expert groups needed to counteract the anti-vaccine propaganda and provide scientific-based information to the general public.

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TL;DR: In this paper, a review examines the pathogens, potentially pathogenic microorganisms and ARGs which may be found in animal manure, and evaluates their effect on human health through their exposure to soil and plant resistomes.
Abstract: Antibiotic resistance genes (ARGs) are a relatively new type of pollutant The rise in antibiotic resistance observed recently is closely correlated with the uncontrolled and widespread use of antibiotics in agriculture and the treatment of humans and animals Resistant bacteria have been identified in soil, animal feces, animal housing (eg, pens, barns, or pastures), the areas around farms, manure storage facilities, and the guts of farm animals The selection pressure caused by the irrational use of antibiotics in animal production sectors not only promotes the survival of existing antibiotic-resistant bacteria but also the development of new resistant forms One of the most critical hot-spots related to the development and dissemination of ARGs is livestock and poultry production Manure is widely used as a fertilizer thanks to its rich nutrient and organic matter content However, research indicates that its application may pose a severe threat to human and animal health by facilitating the dissemination of ARGs to arable soil and edible crops This review examines the pathogens, potentially pathogenic microorganisms and ARGs which may be found in animal manure, and evaluates their effect on human health through their exposure to soil and plant resistomes It takes a broader view than previous studies of this topic, discussing recent data on antibiotic use in farm animals and the effect of these practices on the composition of animal manure; it also examines how fertilization with animal manure may alter soil and crop microbiomes, and proposes the drivers of such changes and their consequences for human health

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TL;DR: In this paper, the authors investigated differences in levels of depressive and generalized anxiety symptoms in four age groups in the Polish population during the COVID-19 lockdown, and found that household relationship difficulties were among the most significant predictors of depression and anxiety.

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TL;DR: Euglenozoa is a species-rich group of protists, which have extremely diverse lifestyles and a range of features that distinguish them from other eukaryotes as discussed by the authors.
Abstract: Euglenozoa is a species-rich group of protists, which have extremely diverse lifestyles and a range of features that distinguish them from other eukaryotes. They are composed of free-living and parasitic kinetoplastids, mostly free-living diplonemids, heterotrophic and photosynthetic euglenids, as well as deep-sea symbiontids. Although they form a well-supported monophyletic group, these morphologically rather distinct groups are almost never treated together in a comparative manner, as attempted here. We present an updated taxonomy, complemented by photos of representative species, with notes on diversity, distribution and biology of euglenozoans. For kinetoplastids, we propose a significantly modified taxonomy that reflects the latest findings. Finally, we summarize what is known about viruses infecting euglenozoans, as well as their relationships with ecto- and endosymbiotic bacteria.

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Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Thomas Bergauer  +2353 moreInstitutions (175)
TL;DR: In this article, a search for leptoquarks produced singly and in pairs in proton-proton collisions is presented, where the lepton is considered to be a scalar particle of charge −1/3e coupling to a top quark plus a tau lepton ( t τ ) or a bottom quark including a neutrino ( b ν ), or a vector particle of a charge +2/3 e coupling to t ν or b τ.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, J. W. Andrejkovic  +2404 moreInstitutions (215)
TL;DR: In this paper, a data set of proton-proton collisions collected by the CMS experiment at the LHC at s = 13 TeV from 2016 to 2018 corresponding to a total integrated luminosity of up to 140 fb−1 is analyzed.
Abstract: A search is presented for physics beyond the standard model (SM) using electron or muon pairs with high invariant mass. A data set of proton-proton collisions collected by the CMS experiment at the LHC at s = 13 TeV from 2016 to 2018 corresponding to a total integrated luminosity of up to 140 fb−1 is analyzed. No significant deviation is observed with respect to the SM background expectations. Upper limits are presented on the ratio of the product of the production cross section and the branching fraction to dileptons of a new narrow resonance to that of the Z boson. These provide the most stringent lower limits to date on the masses for various spin-1 particles, spin-2 gravitons in the Randall-Sundrum model, as well as spin-1 mediators between the SM and dark matter particles. Lower limits on the ultraviolet cutoff parameter are set both for four-fermion contact interactions and for the Arkani-Hamed, Dimopoulos, and Dvali model with large extra dimensions. Lepton flavor universality is tested at the TeV scale for the first time by comparing the dimuon and dielectron mass spectra. No significant deviation from the SM expectation of unity is observed.