University of York

About: University of York is a education organization based out in York, York, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 22089 authors who have published 56925 publications receiving 2458285 citations. The organization is also known as: York University & Ebor..

Molecular basis of agonism and antagonism in the oestrogen receptor.

Abstract: Oestrogens are involved in the growth, development and homeostasis of a number of tissues. The physiological effects of these steroids are mediated by a ligand-inducible nuclear transcription factor, the oestrogen receptor (ER). Hormone binding to the ligand-binding domain (LBD) of the ER initiates a series of molecular events culminating in the activation or repression of target genes. Transcriptional regulation arises from the direct interaction of the ER with components of the cellular transcription machinery. Here we report the crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17beta-oestradiol, and the selective antagonist raloxifene, at resolutions of 3.1 and 2.6 A, respectively. The structures provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties. Agonist and antagonist bind at the same site within the core of the LBD but demonstrate different binding modes. In addition, each class of ligand induces a distinct conformation in the transactivation domain of the LBD, providing structural evidence of the mechanism of antagonism.

A Survey of Outlier Detection Methodologies

Abstract: Outlier detection has been used for centuries to detect and, where appropriate, remove anomalous observations from data. Outliers arise due to mechanical faults, changes in system behaviour, fraudulent behaviour, human error, instrument error or simply through natural deviations in populations. Their detection can identify system faults and fraud before they escalate with potentially catastrophic consequences. It can identify errors and remove their contaminating effect on the data set and as such to purify the data for processing. The original outlier detection methods were arbitrary but now, principled and systematic techniques are used, drawn from the full gamut of Computer Science and Statistics. In this paper, we introduce a survey of contemporary techniques for outlier detection. We identify their respective motivations and distinguish their advantages and disadvantages in a comparative review.

Inside the Black Box: Technology and Economics

Abstract: Explores how technological innovation has shaped and been shaped by science, industry, and economics in the twentieth century. Technological change and specific technologies have impacted productivity, the learning process, technology transfer and technology policies. Starting with a summary of historical literature on technical progress, the book goes on to discuss and promote Karl Marx's influential method of studying technology as the result of interrelated social processes -- especially emphasizing the mutual interaction between technology and the economy. Analysis of current empirical studies shows the need for an enlarged framework for understanding the relation between the economy and technical change. Technological interdependence in the American economy is analyzed, and later expanded to encompass international business. High-tech industries are discussed as particularly reliant upon scientific research. The commercial aircraft industry from 1925-75 is also examined, as an exemplary instance in which technological innovation and government support and regulation allowed for economic success. The book concludes that scientific progress is heavily influenced by technological considerations that are, in turn, shaped by industry and economics. Thus, decisions made in the private and public sectors should affect both supply and demand, favoring the creative, mutually advantageous connection between science and technology. (CJC)

Molecular replacement with MOLREP

Abstract: MOLREP is an automated program for molecular replacement that utilizes a number of original approaches to rotational and translational search and data preparation. Since the first publication describing the program, MOLREP has acquired a variety of features that include weighting of the X-ray data and search models, multi-copy search, fitting the model into electron density, structural superposition of two models and rigid-body refinement. The program can run in a fully automatic mode using optimized parameters calculated from the input data.

Quantum Information with Continuous Variables

Abstract: Preface. About the Editors. Part I: Quantum Computing. 1. Quantum computing with qubits S.L. Braunstein, A.K. Pati. 2. Quantum computation over continuous variables S. Lloyd, S.L. Braunstein. 3. Error correction for continuous quantum variables S.L. Braunstein. 4. Deutsch-Jozsa algorithm for continuous variables A.K. Pati, S.L. Braunstein. 5. Hybrid quantum computing S. Lloyd. 6. Efficient classical simulation of continuous variable quantum information processes S.D. Bartlett, B.C. Sanders, S.L. Braunstein, K. Nemoto. Part II: Quantum Entanglement. 7. Introduction to entanglement-based protocols S.L. Braunstein, A.K. Pati. 8. Teleportation of continuous uantum variables S.L. Braunstein, H.J. Kimble. 9. Experimental realization of continuous variable teleportation A. Furusawa, H.J. Kimble. 10. Dense coding for continuous variables S.L. Braunstein, H.J. Kimble. 11. Multipartite Greenberger-Horne-Zeilinger paradoxes for continuous variables S. Massar, S. Pironio. 12. Multipartite entanglement for continuous variables P. van Loock, S.L. Braunstein. 13. Inseparability criterion for continuous variable systems Lu-Ming Duan, G. Giedke, J.I. Cirac, P. Zoller. 14. Separability criterion for Gaussian states R. Simon. 15. Distillability and entanglement purification for Gaussian states G. Giedke, Lu-Ming Duan, J.I. Cirac, P. Zoller. 16. Entanglement purification via entanglement swapping S. Parke, S. Bose, M.B. Plenio. 17. Bound entanglement for continuous variables is a rare phenomenon P. Horodecki, J.I. Cirac, M. Lewenstein. Part III: Continuous Variable Optical-Atomic Interfacing. 18. Atomic continuous variable processing and light-atoms quantum interface A. Kuzmich, E.S. Polzik. Part IV: Limits on Quantum Information and Cryptography. 19. Limitations on discrete quantum information and cryptography S.L. Braunstein, A.K. Pati. 20. Quantum cloning with continuous variables N.J. Cerf. 21. Quantum key distribution with continuous variables in optics T.C. Ralph. 22. Secure quantum key distribution using squeezed states D. Gottesman, J. Preskill. 23. Experimental demonstration of dense coding and quantum cryptography with continuous variables Kunchi Peng, Qing Pan, Jing Zhang, Changde Xie. 24. Quantum solitons in optical fibres: basic requisites for experimental quantum communication G. Leuchs, Ch. Silberhorn, E. Konig, P.K. Lam, A. Sizmann, N. Korolkova. Index.