Institution
University of York
Education•York, York, United Kingdom•
About: University of York is a education organization based out in York, York, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 22089 authors who have published 56925 publications receiving 2458285 citations. The organization is also known as: York University & Ebor..
Topics: Population, Health care, Context (language use), Randomized controlled trial, Cost effectiveness
Papers published on a yearly basis
Papers
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TL;DR: Several therapeutic strategies for treating AD on the basis of the important role of tau hyperphosphorylation in the pathogenesis of the disease are described and are likely to lead to disease-modifying therapies for AD.
Abstract: Alzheimer disease (AD) is the most common cause of dementia in adults. The current therapy for AD has only moderate efficacy in controlling symptoms, and it does not cure the disease. Recent studies have suggested that abnormal hyperphosphorylation of tau in the brain plays a vital role in the molecular pathogenesis of AD and in neurodegeneration. This article reviews the current advances in understanding of tau protein, regulation of tau phosphorylation, and the role of its abnormal hyperphosphorylation in neurofibrillary degeneration. Furthermore, several therapeutic strategies for treating AD on the basis of the important role of tau hyperphosphorylation in the pathogenesis of the disease are described. These strategies include (1) inhibition of glycogen synthase kinase-3beta (GSK-3beta), cyclin-dependent kinase 5 (cdk5), and other tau kinases; (2) restoration of PP2A activity; and (3) targeting tau O-GlcNAcylation. Development of drugs on the basis of these strategies is likely to lead to disease-modifying therapies for AD.
467 citations
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01 Jan 1995TL;DR: From the perspective of developmental psychoanalysis, the authors makes a case for what the author calls gender heterodoxy, an original view of the similarities and differences between the sexes, and illuminates aspects of love, sexuality, aggression and pornography.
Abstract: From the perspectives of developmental psychoanalysis, this book makes a case for what the author calls gender heterodoxy, an original view of the similarities and differences between the sexes. In the process, she illuminates aspects of love, sexuality, aggression and pornography.
467 citations
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TL;DR: In this paper, the authors discuss the relation between economic growth and environmental quality, and the link between economic activity and the carrying capacity and resilience of the environment (e.g., water quality).
465 citations
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TL;DR: This mini-review will summarize recent findings relating to sialic acid transport, modification of sialing acid by O-acetylation, and the mechanisms of sIALic acid-mediated complement resistance.
Abstract: Sialic acid occupies the terminal position within glycan molecules on the surfaces of many vertebrate cells, where it functions in diverse cellular processes such as intercellular adhesion and cell signalling. Pathogenic bacteria have evolved to use this molecule beneficially in at least two different ways: they can coat themselves in sialic acid, providing resistance to components of the host's innate immune response, or they can use it as a nutrient. Sialic acid itself is either synthesized de novo by these bacteria or scavenged directly from the host. In this mini-review we will summarize recent findings relating to sialic acid transport, modification of sialic acid by O-acetylation, and the mechanisms of sialic acid-mediated complement resistance.
465 citations
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TL;DR: In this article, social scientists should explicitly recognize the existence of consumers who engage in "craft consumption" and, hence, of an additional image of the consumer to set along with the consumer image.
Abstract: This article proposes that social scientists should explicitly recognize the existence of consumers who engage in ‘craft consumption’ and, hence, of an additional image of the consumer to set along...
464 citations
Authors
Showing all 22432 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cyrus Cooper | 204 | 1869 | 206782 |
Eric R. Kandel | 184 | 603 | 113560 |
Ian J. Deary | 166 | 1795 | 114161 |
Elio Riboli | 158 | 1136 | 110499 |
Claude Bouchard | 153 | 1076 | 115307 |
Robert Plomin | 151 | 1104 | 88588 |
Kevin J. Gaston | 150 | 750 | 85635 |
John R. Hodges | 149 | 812 | 82709 |
Myrna M. Weissman | 149 | 772 | 108259 |
Jeffrey A. Lieberman | 145 | 706 | 85306 |
Howard L. Weiner | 144 | 1047 | 91424 |
Dan J. Stein | 142 | 1727 | 132718 |
Jedd D. Wolchok | 140 | 713 | 123336 |
Bernard Henrissat | 139 | 593 | 100002 |
Joseph E. LeDoux | 139 | 478 | 91500 |