Uzhhorod National University

About: Uzhhorod National University is a education organization based out in Uzhhorod, Ukraine. It is known for research contribution in the topics: Raman spectroscopy & Laser. The organization has 1089 authors who have published 1056 publications receiving 5187 citations. The organization is also known as: State Higher Education Establishment "Uzhhorod National University" & Uzhhorod State University.

Skin microbial landscape and immune-endocrine parameters in patients with psoriasis by using narrowband UVB phototherapy.

Abstract: Objective The aim: The study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy. Patients and methods Materials and methods: We examined 89 patients with psoriasis (51 men and 38 women) aged 18-60. The comparison group consisted of 43 psoriasis patients comparable by age, sex and clinical course with those from the main group (46 patients). Cytokine levels IL-4, IL-8, IL-10, TNFα, thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies and microbial flora of skin were determined in patients with psoriasis. Results Results: The study finds that conventional therapy does not have sufficient corrective impact on immune-endocrine disorders and the use of narrow-band light therapy has shown that it has a focused corrective impact on cytokine production and modulating effect on the level of TPO and Tg autoantibodies and the state of skin automicroflora of lesions in patients suffering from psoriasis. Conclusion Conclusions: Using UVB (311 nm) therapy in patients with psoriasis allows improving efficiency of treatment and limiting clinical signs in the form of achieving remission and significant improvement in patients' health without any negative dynamic changes.

Simultaneous multi-site photometry of leo satellites to characterise their rotation states

Abstract: The photometry of space objects (SO)makes it possible to determine their state of rotation aroundthe center of mass, orientation of the rotation axis androtation speed in the most cost-effective manner. However,the methods for determining the attitude parameters fromphotometric data from a single observation site (OS) requirelong series of high-quality and high-frequencymeasurements. We propose a method for determining theorientation parameters of slowly rotating SO based onsimultaneous multi-site photometry with a high temporalresolution. Preconditions for planning and building a localphotometric network that can accomplish such a task havebeen tested via computer simulation. Synchronousobservations of the unoperated spacecraft TOPEX/Poseidonwere carried out. They were attended by the observatories ofOdessa, Lvov and Uzhgorod universities, as well as theobservation station of the State Space Agency of Ukraine inZalistsi, Khmelnytsky region, took part. Synchronousnetwork-based photometric observations from three OSsenable us to calculate time lags between correlated light-curve segments and promptly determine the direction ofrotation, as well as the spatial orientation of a SO’s spin axisand its angular spin rate. A local network of severaldistributed observation sites for synchronous monitoring ofthe rotation of various SO in LEO will make it possible todetermine the rotation parameters of also slowly rotatingobjects that do not exhibit glints within their light curves.

Lipoprotein associated phospholipase a2 as a marker of vulnerable atherosclerotic plaque in patients with internal carotid artery stenosis.

Abstract: The aim of this study was to compare the concentration of inflammatory vascular markers and morphological structure of atherosclerotic plaque in symptomatic and asymptomatic patients with the stenosis of internal carotid artery (ICA). The research was carried out in 70 patients with hemodynamically significant stenosis of ICA out of which 40 (57%) were asymptomatic patients and 30 (43%) were symptomatic patients, of which 20 patients (66%) have had a stroke, or transient ischemic attack (TIA), 10 patients (33%). All the patients were indicated to carotid endarterectomy as a surgical prevention of stroke. All the patients were taken their blood for biochemical testing (T-Chol, LDL, HDL, TG, Fibrinogen, CRP and specific markers IL-4 and Lp-PLA2) early morning prior to surgery. The highest concentrations of T-Chol, LDL, HDL, CRP and Fibrinogen were measured in symptomatic patients, however, these did not feature a significant difference compared with the group of asymptomatic patients (P>0.05). Significant difference was found in IL-4 (P<0.001) and in Lp-PLA2 (P<0.001). When evaluating concentration of tracked parameters in patients with soft atherosclerotic plaque and patients with calcified atherosclerotic plaque, significant differences were found in these markers: TG (P<0.05), CRP (P<0.01), IL-4 (P<0.001) and Lp-PLA2 (P<0.001). The paper deals with higher concentrations of Lp-PLA2 in patients with a soft atherosclerotic plaque. Higher concentration of Lp-PLA2 and systemic inflammatory markers (CRP, IL-4) could be used along with ultrasonography to detect mainly asymptomatic patients who are in urgent need of surgical or endovascular treatment as a prevention of stroke.

Peculiarities of determining the gastric acid secretion and diabetic autonomic neuropathy in patients with chronic pancreatitis and type 2 diabetes.

Abstract: Objective The aim: Is to determine the peculiarities of changes in the gastric acid secretion against the background of diabetic autonomic neuropathy and autonomic dysfunction in patients with chronic pancreatitis (CP) and type 2 diabetes (T2DM). Patients and methods Materials and methods: We investigated 64 patients with CP and T2DM, who were included in the first group of the patients examined; Group II consisted of 40 patients with T2DM; and Group III of the patients examined consisted of 34 patients with CP. Results Results: Differences were found in assessing the degree of autonomic nervous system (ANS) dysfunction in the examined patients, namely - the most pronounced ANS dysfunction according to the Wayne questionnaire was diagnosed in patients Group I, while patients of Group III. Analysis of gastric acid secretion indicates that no patients of Group III had normal acidity. Normal acidity is more often found in the second group of subjects. Both in patients with CP and T2DM, and in isolation with CP, moderate hyperacidity was more often determined. Conclusion Conclusions: The predominance of the parasympathetic division of the ANS, as well as manifestations of severe ANS dysfunction, are observed in patients with CP and T2DM. The prevalence of gastric hyperacidity on the background of DAN was established in patients with CP and T2DM. In this case, the absence of clinical symptoms or their minimal severity is determined, which indicates the lesion of the digestive tract in these patients.

A UV lamp based on a Kr-Xe mixture with Br2 and I2 molecules

Abstract: A small-size broadband ultraviolet lamp with an emission spectrum of 206–390 nm, which is excited by a dc glow discharge, is described. The discharge was ignited in a quartz discharge tube with an inner diameter of 1.4 cm and an anode-cathode spacing of 10 cm. The tube was filled with a Kr/Xe/Br2/I2 working mixture, the total pressure being 0.5–2.0 kPa. The lamp’s emission spectrum consisted of a 206.2-nm iodine atomic line 0.1 nm wide at half-height and a continuum in a spectral region of 210–390 nm. The continuum resulted from overlapping of wide emission bands with peaks at 221 nm for XeBr(D-X), 253 nm for XeI(B-X), 282 nm for XeBr(B-X), 289 nm for Br 2 * , 342 nm for I 2 * , and 386 nm for IBr*. The total power of the ultraviolet emission was no more than 8–12 W, the power injected into the discharge being 10–100 W. The lamp lifetime in the gas-static mode was 300–400 h.