Institution
Xiamen University
Education•Amoy, Fujian, China•
About: Xiamen University is a education organization based out in Amoy, Fujian, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 50472 authors who have published 54480 publications receiving 1058239 citations. The organization is also known as: Amoy University & Xiàmén Dàxué.
Topics: Catalysis, Population, Computer science, Chemistry, Graphene
Papers published on a yearly basis
Papers
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TL;DR: The role of sTREM2 is studied in a mouse model of Alzheimer’s disease, and it is found it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer's disease (AD). A proteolytic product, soluble TREM2 (sTREM2), is abundant in the cerebrospinal fluid and its levels positively correlate with neuronal injury markers. To gain insights into the pathological roles of sTREM2, we studied sTREM2 in the brain of 5xFAD mice, a model of AD, by direct stereotaxic injection of recombinant sTREM2 protein or by adeno-associated virus (AAV)-mediated expression. We found that sTREM2 reduces amyloid plaque load and rescues functional deficits of spatial memory and long-term potentiation. Importantly, sTREM2 enhances microglial proliferation, migration, clustering in the vicinity of amyloid plaques and the uptake and degradation of Aβ. Depletion of microglia abolishes the neuroprotective effects of sTREM2. Our study demonstrates a protective role of sTREM2 against amyloid pathology and related toxicity and suggests that increasing sTREM2 can be explored for AD therapy.
198 citations
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TL;DR: The "Hippo" signaling pathway, as delineated by genetic and biochemical studies in Drosophila, consists of a kinase cascade regulated by cell-cell contact and cell polarity that inhibits the transcriptional coactivator Yorkie and its proliferative, anti-differentiation, antiapoptotic transcriptional program.
197 citations
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TL;DR: In this paper, a polycrystalline Pd disk electrode in alkaline media was studied by in situ Fourier transform infrared (FTIR) reflection spectroscopy, which revealed that most of ethanol was incompletely oxidized to acetate.
197 citations
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TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, the objective of which is to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
197 citations
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TL;DR: For example, National Natural Science Foundation of China [50973019, 5084303030], National Basic Research Program [2010CB732203] as discussed by the authors, National Natural Sciences Foundation of Fujian Province [E0620001]
197 citations
Authors
Showing all 50945 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zhong Lin Wang | 245 | 2529 | 259003 |
Lei Jiang | 170 | 2244 | 135205 |
Yang Gao | 168 | 2047 | 146301 |
William A. Goddard | 151 | 1653 | 123322 |
Rui Zhang | 151 | 2625 | 107917 |
Xiaoyuan Chen | 149 | 994 | 89870 |
Fuqiang Wang | 145 | 1518 | 95014 |
Galen D. Stucky | 144 | 958 | 101796 |
Shu-Hong Yu | 144 | 799 | 70853 |
Wei Huang | 139 | 2417 | 93522 |
Bin Liu | 138 | 2181 | 87085 |
Jie Liu | 131 | 1531 | 68891 |
Han Zhang | 130 | 970 | 58863 |
Lei Zhang | 130 | 2312 | 86950 |
Jian Zhou | 128 | 3007 | 91402 |