Xiamen University

About: Xiamen University is a education organization based out in Amoy, Fujian, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 50472 authors who have published 54480 publications receiving 1058239 citations. The organization is also known as: Amoy University & Xiàmén Dàxué.

Stabilization of anti-aromatic and strained five-membered rings with a transition metal

Abstract: Anti-aromatic compounds, as well as small cyclic alkynes or carbynes, are particularly challenging synthetic goals. The combination of their destabilizing features hinders attempts to prepare molecules such as pentalyne, an 8p-electron antiaromatic bicycle with extremely high ring strain. Here we describe the facile synthesis of osmapentalyne derivatives that are thermally viable, despite containing the smallest angles observed so far at a carbyne carbon. The compounds are characterized using X-ray crystallography, and their computed energies and magnetic properties reveal aromatic character. Hence, the incorporation of the osmium centre not only reduces the ring strain of the parent pentalyne, but also converts ′ ′

Tumor Microenvironment-Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy.

Abstract: The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn2+-assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment-triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy. MnO2 nanosheets serve as a highly effective DVDMS carrier and in situ oxygen and nanoDVD generator. In MCF-7 cells and xenograft tumors, MnO2/DVDMS is reduced by glutathione (GSH) and H2O2 and reassembled into nanoDVD, which can be monitored by activated magnetic resonance/fluorescence/photoacoustic signals. Intriguingly, the decrease of GSH, the production of O2, and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor efficacy in vitro and in vivo, offering a new avenue for cancer theranostics.

IMDS: intelligent malware detection system

Abstract: The proliferation of malware has presented a serious threat to the security of computer systems. Traditional signature-based anti-virus systems fail to detect polymorphic and new, previously unseen malicious executables. In this paper, resting on the analysis of Windows API execution sequences called by PE files, we develop the Intelligent Malware Detection System (IMDS) using Objective-Oriented Association (OOA) mining based classification. IMDS is an integrated system consisting of three major modules: PE parser, OOA rule generator, and rule based classifier. An OOA_Fast_FP-Growth algorithm is adapted to efficiently generate OOA rules for classification. A comprehensive experimental study on a large collection of PE files obtained from the anti-virus laboratory of King-Soft Corporation is performed to compare various malware detection approaches. Promising experimental results demonstrate that the accuracy and efficiency of our IMDS system out perform popular anti-virus software such as Norton AntiVirus and McAfee VirusScan, as well as previous data mining based detection systems which employed Naive Bayes, Support Vector Machine (SVM) and Decision Tree techniques.

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Abstract: Synaptic abnormalities and learning dysfunction are prominent characteristics of Down's syndrome. Now Huaxi Xu and colleagues show that expression of the protein SNX27 is reduced in Down's syndrome brains and that restoring its expression can ameliorate learning dysfunction in a mouse model of the disease.