Showing papers in "Journal of Crohn's and Colitis in 2021"

TL;DR: An evidence-supported update of the ECCO-ESPGHAN guideline on the medical management of paediatric Crohn's disease is provided, establishing that it was key to identify patients at high risk of a complicated disease course at the earliest opportunity to reduce bowel damage.

TL;DR: The authors in this paper provided an updated review of the burden of IBD in Europe by discussing current data on epidemiology, disease course, risk for surgery, hospitalisation, and mortality and cancer risks, as well as the economic aspects, patient disability, and work impairment, by discussing the latest population-based studies from the region.

TL;DR: A comparable COVID-19 risk was found between the IBD cohort and the general Dutch population and the presence of ≥1 comorbidities was an independent risk factor for hospitalisation due to CO VID-19.

TL;DR: Two-thirds of patients recaptured response following treatment intensification with ustekinumab 90 mg every 4 weeks are recaptured following this multicenter cohort study on Crohn's disease.

TL;DR: A simple oligo-protein panel has been characterised that has the potential to identify IBD from symptomatic controls and to predict future disease course.

TL;DR: Patients with perianal CD were found to have an increased risk of undergoing major abdominal surgery and the risk of anal and rectal cancer was increased in patients with peranal CD compared to non-IBD matched controls.

TL;DR: This study corroborates the diagnostic equivalence of FLCN2 and FCAL in IBD and indicates that persistent mucosal overexpression renders LCN2 an attractive candidate for molecular inflammation warranting further investigation.

TL;DR: Both UST and ADA were highly effective in this population of biologic-naïve pts with moderate-to-severe Crohn’s disease, and major secondary endpoints were similar between groups, as were remission rates at assessment points through W52.

TL;DR: In this article, an ultrasonographic activity index using endoscopy as the reference standard was developed, which showed strong correlation with endoscopic disease activity using internal validation, and it is currently being validated in prospective studies.

TL;DR: Elderly-onset IBD patients were associated with increased risk of infections, cancer development and increased infections- and IBD-related hospitalizations and specific therapeutic strategies to target this special population is needed.

TL;DR: The overall risk of colectomy in this cohort was lower than expected from previous studies, although considerable for patients with extensive colitis at diagnosis, and early mucosal healing was associated with better disease outcomes 20 years after diagnosis.

TL;DR: The data suggest that pregnancy should be planned when the disease is quiescent, and continuous disease control is important even during pregnancy.

TL;DR: Ontamalimab was well tolerated up to 144 weeks in patients with moderate-to-severe UC, with good safety and efficacy.

TL;DR: Investigation of the roles of MLCK splice variants in gut barrier defects under proinflammatory stress found proinflammatory cytokines induced bacterial influx through transcellular and paracellular routes via divergent pathways orchestrated by distinct M LCK isoforms.

TL;DR: In this article, the small intestine microbial composition and metabolic potential, in the context of inflammatory bowel disease (IBD), was explored, with 57 individuals with an ileostomy or ileoanal pouch, compared with 1178 general population and 478 IBD faecal metagenomes.

TL;DR: The findings suggest that tofacitinib is quite effective in protecting from colitis by inhibition of a bundle of T cell derived cytokines like IL-5,IL-6, IL-9, Il-13 and IL-17A.

TL;DR: In this article, the authors conducted a network meta-analysis to examine the optimum preparation, dose, and route of administration for 5-Aminosalicylates (5-ASAs) for ulcerative colitis.

TL;DR: As more than two-thirds of the quality metrics in IBD are based on low quality evidence, further studies are needed to improve the overall quality of evidence supporting the development of quality measures.

TL;DR: In a large cohort of patients, the IBD-disk score was well correlated with IBD daily-life burden, and it could be used in clinical practice.

TL;DR: Olamkicept induction therapy demonstrated clinical efficacy with respect to achieving clinical response, clinical remission and mucosal healing in patients with active UC, and was well tolerated with a favourable safety profile.

TL;DR: Local MSCs injection in non-passable CD stricture was well tolerated over the short term but several occlusions were reported in the follow-up, suggesting combining the effects of M SCs with the proven effect of endoscopic balloon dilatation could possibly improve the outcome of CD strictures.

TL;DR: It is proposed that the beneficial effects of intermittent fasting in experimental colitis can at least be partly attributed to increased levels of A. municiphila and subsequent propionate-mediated induction of Reg3 lectins in the epithelial compartment.

TL;DR: This study shows that both genotype and multiple disease phenotypes strongly associate with the plasma proteome in patients with IBD and identifies disease-associated pathways that may help to improve disease management in the future.

TL;DR: Gastroenterology services have an important role to play in helping patients to overcome the challenges they encounter in their everyday life, both by providing individual patients with culturally appropriate care and advice, and via interventions to increase awareness and understanding of IBD within wider South Asian communities.

TL;DR: The diagnosis of IBD-like features mainly occurs after that of hypogammaglobulinemia, the majority of cases successfully recovered after appropriate treatment, and this case series illustrates a strong male and CD- like features predilection.

TL;DR: While pregnancy should be avoided in patients on and 3 months after stopping ozanimod and clinical experience with ozAnimod during pregnancy is limited, there has been no increased event of foetal abnormalities or adverse pregnancy outcomes seen withozanimod exposure in early pregnancy.

TL;DR: In this article, the role of MAP in disease progression and genetic susceptibility was investigated in inflammatory bowel disease (IBD) and Crohn's disease (CD) using serology test results from 812 patients with seven immunoglobulin [Ig] isotype-specific serology tests.

TL;DR: AJM300 may become a novel therapeutic option for patients who had inadequate response or intolerance to oral 5-ASA and induced clinical response as well as endoscopic remission with good tolerability.

TL;DR: This is first trial indicating that children/adolescents with CD responding to EEN as induction therapy can be maintained on remission with a nutritional therapy without immunosuppressors/biologics, however, daily nutritional supplement with normal access to food was not successful with a relapse rate of 76%.

TL;DR: This large, real-world, multicenter study demonstrated the effectiveness and safety of VDZ as a first-line biologic, showing high rates of clinical response and steroid-free remission at both induction and maintenance.