2013 Alzheimer's disease facts and figures
William Thies,Laura Bleiler +1 more
Reads0
Chats0
TLDR
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general.Abstract:
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long‐distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom generation is projected to add about 10 million to the total number of people in the United States with AD. Today, someone in America develops AD every 68 seconds. By 2050, one new case of AD is expected to develop every 33 seconds, or nearly a million new cases per year, and the total estimated prevalence is expected to be 13.8 million. AD is the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age 65 years or older. Between 2000 and 2010, the proportion of deaths resulting from heart disease, stroke, and prostate cancer decreased 16%, 23%, and 8%, respectively, whereas the proportion resulting from AD increased 68%. The number of deaths from AD as determined by official death certificates (83,494 in 2010) likely underrepresents the number of AD‐related deaths in the United States. A projected 450,000 older Americans with AD will die in 2013, and a large proportion will die as a result of complications of AD. In 2012, more than 15 million family members and other unpaid caregivers provided an estimated 17.5 billion hours of care to people with AD and other dementias, a contribution valued at more than $216 billion. Medicare payments for services to beneficiaries age 65 years and older with AD and other dementias are three times as great as payments for beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2013 for health care, long‐term care, and hospice services for people age 65 years and older with dementia are expected to be $203 billion (not including the contributions of unpaid caregivers). An estimated 2.3 million caregivers of people with AD and other dementias live at least 1 hour away from the care recipient. These “long‐distance caregivers” face unique challenges, including difficulty in assessing the care recipient's true health condition and needs, high rates of family disagreement regarding caregiving decisions, and high out‐of‐pocket expenses for costs related to caregiving. Out‐of‐pocket costs for long‐distance caregivers are almost twice as high as for local caregivers.read more
Citations
More filters
Journal ArticleDOI
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
TL;DR: The A β-dependent and Aβ-independent mechanisms that link Apo-E4 status with AD risk are discussed, and how to design effective strategies for AD therapy by targeting ApO-E is considered.
Journal ArticleDOI
The amyloid state and its association with protein misfolding diseases
TL;DR: The ability to form the amyloid state is more general than previously imagined, and its study can provide unique insights into the nature of the functional forms of peptides and proteins, as well as understanding the means by which protein homeostasis can be maintained and protein metastasis avoided.
Journal ArticleDOI
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
TL;DR: It is demonstrated that relatively few clinical trials are undertaken for AD therapeutics, considering the magnitude of the problem, and the success rate for advancing from one phase to another is low and the number of compounds progressing to regulatory review is among the lowest found in any therapeutic area.
Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Journal ArticleDOI
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective.
TL;DR: There is sufficiently strong evidence, from a population‐based perspective, to conclude that regular physical activity and management of cardiovascular risk factors reduce the risk of cognitive decline and may reduce therisk of dementia.
References
More filters
Deaths: final data for 2010.
TL;DR: The decline of the age-adjusted death rate to a record low value for the United States, and the increase in life expectancy to arecord high value of 78.7 years, are consistent with long-term trends in mortality.
Journal ArticleDOI
Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players
Kevin M. Guskiewicz,Stephen W. Marshall,Julian E. Bailes,Michael McCrea,Robert C. Cantu,Christopher Randolph,Barry D. Jordan +6 more
TL;DR: The findings suggest that the onset of dementia-related syndromes may be initiated by repetitive cerebral concussions in professionalFootball players, and an earlier onset of Alzheimer's disease in the retirees than in the general American male population.
Journal ArticleDOI
How Effective Are Interventions With Caregivers? An Updated Meta-Analysis
TL;DR: Caregiver interventions are effective, but some interventions have primarily domain-specific effects rather than global effects and the differences between intervention types and moderators suggest ways of optimizing interventions.
Journal ArticleDOI
Slowing of wound healing by psychological stress
TL;DR: The effects of psychological stress, caused by caring for a relative with Alzheimer's disease, on wound healing are investigated and stress-related defects in wound repair could have important clinical implications, for instance for recovery from surgery.
Income, poverty, and health insurance coverage in the United States: 2007.
C. M. Gutierrez,J. J. Sullivan,C. A. Glassman,S. H. Murdock,C. DeNavas-Walt,B. D. Proctor,J. C. Smith +6 more
TL;DR: The authors 14.3 7.0 6.0 7.5 1.1 1.2 0.9 0.7 0.6 0.8 1.4 1.3 15.8 15.2 1.6 17.1 16.3 * 1.9 * 0.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more