3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
Journal ArticleDOI
Nanomaterial-Enabled Wearable Sensors for Healthcare.
TL;DR: Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review.
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3D bioprinting of tissues and organs for regenerative medicine.
TL;DR: The current status and contemporary issues of 3D bioprinting pertaining to the eleven organ systems of the human body including skeletal, muscular, nervous, lymphatic, endocrine, reproductive, integumentary, respiratory, digestive, urinary, and circulatory systems were critically reviewed.
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
TL;DR: This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.
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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering
TL;DR: Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors.
References
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Development of Novel Three-Dimensional Printed Scaffolds for Osteochondral Regeneration
TL;DR: A series of innovative bi-phasic 3D models that mimic the osteochondral region of articulate joints with both excellent interfacial mechanical properties and biocompatibility for facilitating human bone marrow mesenchymal stem cell (MSC) growth and chondrogenic differentiation.
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Micro-precise spatiotemporal delivery system embedded in 3D printing for complex tissue regeneration.
TL;DR: A micro-precise spatiotemporal delivery system embedded in 3D printed scaffolds may serve as an efficient tool to regenerate complex and inhomogeneous tissues.
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Formation of blood clot on biomaterial implants influences bone healing.
TL;DR: In this paper, the formation of a blood clot during bone healing in related to the use of platelet-rich plasma (PRP) gels is investigated, and the results indicate that the effect of clots on bone regeneration depends on how the clots are formed.
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Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect.
Jin-Hyung Shim,Se Eun Kim,Ju Young Park,Joydip Kundu,Sung Won Kim,Seong Soo Kang,Dong-Woo Cho +6 more
TL;DR: In the in vivo animal experiements, microcomputed tomography and histological analyses confirmed that PCL/PLGA/collagen/rhBMP-2 scaffolds (long-term delivery mode) showed the best bone healing quality at both weeks 4 and 8 after implantation without inflammatory response.
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Design Paradigm Utilizing Reversible Diels–Alder Reactions to Enhance the Mechanical Properties of 3D Printed Materials
Joshua R. Davidson,Gayan A. Appuhamillage,Christina M. Thompson,Walter Voit,Ronald A. Smaldone +4 more
TL;DR: It is demonstrated that a thermally reversible cross-linking paradigm based on the furan-maleimide Diels-Alder (fmDA) reaction can be more broadly applied to engineer property enhancements and remending abilities to a host of other 3D printable materials with superior mechanical properties.