3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
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Nanomaterial-Enabled Wearable Sensors for Healthcare.
TL;DR: Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review.
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3D bioprinting of tissues and organs for regenerative medicine.
TL;DR: The current status and contemporary issues of 3D bioprinting pertaining to the eleven organ systems of the human body including skeletal, muscular, nervous, lymphatic, endocrine, reproductive, integumentary, respiratory, digestive, urinary, and circulatory systems were critically reviewed.
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
TL;DR: This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.
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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering
TL;DR: Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors.
References
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Journal ArticleDOI
3D-printing technologies for electrochemical applications
Adriano Ambrosi,Martin Pumera +1 more
TL;DR: A general overview of the most commonly available 3D-printing methods along with a review of recent electrochemistry related studies adopting 3D -printing as a possible rapid prototyping fabrication tool is provided.
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Direct 3D bioprinting of perfusable vascular constructs using a blend bioink
Weitao Jia,Weitao Jia,Weitao Jia,P. Selcan Gungor-Ozkerim,P. Selcan Gungor-Ozkerim,Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Kan Yue,Kan Yue,Kai Zhu,Kai Zhu,Kai Zhu,Wanjun Liu,Wanjun Liu,Qingment Pi,Qingment Pi,Batzaya Byambaa,Batzaya Byambaa,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Ali Khademhosseini +25 more
TL;DR: A versatile 3D bioprinting strategy that employs biomimetic biomaterials and an advanced extrusion system to deposit perfusable vascular structures with highly ordered arrangements in a single-step process, superior to conventional microfabrication or sacrificial templating approaches for fabrication of the perfusable vasculature.
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Omnidirectional printing of 3D microvascular networks.
TL;DR: Omnidirectional printing of 3D Microvascular Networks for self-healing and distribution for autonomic healing, cooling, and energy harvesting.
Journal ArticleDOI
3D Printing of Scaffolds for Tissue Regeneration Applications
TL;DR: The criteria for printing viable and functional scaffolds, scaffolding materials, and 3DP technologies used to print scaffolds for tissue engineering are discussed and could potentially help to meet the demand by patients for tissues and organs without having to wait or rely on donors for transplantation.
Journal ArticleDOI
Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink.
Cristina Colosi,Cristina Colosi,Cristina Colosi,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Vijayan Manoharan,Vijayan Manoharan,Solange Massa,Solange Massa,Solange Massa,Marco Costantini,Andrea Barbetta,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mariella Dentini,Ali Khademhosseini +17 more
TL;DR: A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented, which incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures.