3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Physics-based and data-driven modeling for biomanufacturing 4.0
Michael Ogunsanya,Salil Desai +1 more
TL;DR: In this paper , a physics-based model was integrated with a memory-based data-driven model to provide predictive capabilities for bioprinting. And the hybrid approach used the long short-term memory (LSTM) network to provide real-time predictions of the bi-printing process parameters as demonstrated by an illustrated case study.
Journal ArticleDOI
Current Status and Future Outlook of Additive Manufacturing Technologies for the Reconstruction of the Trachea
Hwa-Yong Lee,Jin Woo Lee +1 more
TL;DR: In this article , a review of the 3D printing and bioprinting technologies used in tracheal reconstruction is presented, and various research results related to the reconstruction of mucous membranes, cartilage, blood vessels, and muscle tissue are classified.
Journal ArticleDOI
Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing
Yikun Mei,Dongwei Wu,Johanna Berg,Beatrice Tolksdorf,Viola Roehrs,Anke Kurreck,Thomas D Hiller,Jens Kurreck +7 more
TL;DR: In this article , a non-small cell lung cancer model with a perfusion system was generated by digital light processing (DLP) and compared to static and dynamic cultivation by perfusion.
Journal ArticleDOI
Three-dimensional bioprinting of functional β-islet-like constructs
TL;DR: The use of supporting cells, such as endothelial cells, regulatory T cells, and mesenchymal stem cells, in the bioprinting of pancreatic islet-like construct could enhance vasculogenesis and regulate immune activity as mentioned in this paper .
Journal ArticleDOI
Scaffold printing using biodegradable poly(1,4-butylene carbonate) ink: printability, in vivo physicochemical properties, and biocompatibility.
Yun Bae Ji,Ji-Yong Park,You Jung Kang,S. Lee,Hyeon Jin Ju,Sung-E Choi,Bun Yeoul Lee,Moon Suk Kim +7 more
TL;DR: In this paper, the applicability of biodegradable poly(1,4-butylene carbonate) (PBC) as a printing ink for fused deposition modeling (FDM) was evaluated.
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